OceanSwimmer

Can I pin someone else’s tweet? This 💯

@Neuroscope_mp @lisa_chaia Thank you for detailing this response with regards to Crohn’s disease

Yes and Crohn's has a genuinely fascinating and specific story in this space. First the direct parallel. The same Erlangen group that treated lupus just published the world's first CAR-T case for ulcerative colitis in NEJM 2025. A 21 year old woman. Five years of severe UC. Failed every medication. After a single infusion — complete mucosal healing. Drug free. Living normally. Crohn's is the next logical step in IBD. But here is what makes Crohn's especially interesting. Because Crohn's involves dysregulated immune responses to gut bacteria — not just pure autoimmunity — researchers have developed a completely novel approach. FliC-CAR Treg cells. Engineered regulatory T cells targeting a flagellin protein from gut bacteria. Designed to home specifically to the intestine and locally suppress inflammation right where it is happening. No systemic immunosuppression. Targeted. Precise. Published preclinical data is already strong. A Phase 1 Treg trial for Crohn's specifically has already run under NCT03185000. And a survey of IBD patients showed most would actively choose CAR Treg therapy if available — the demand is there. Standard CD19 CAR-T for Crohn's. CAR Treg cells targeting gut specific antigens. Two completely different CAR approaches. Both pointing directly at Crohn's disease. The science is moving. Watch this space very closely. 🔬

🚨 BREAKING: German researchers treated 15 severe lupus patients with CAR-T therapy. All 15 went into complete remission. Many stopped ALL medication. Now a larger trial just confirmed it — across 3 autoimmune diseases. This might be the biggest shift in autoimmune medicine in decades. 🧵

Do you want to go for a walk? 🐶🤣

This is what real consequences for animal cruelty look like: 4 years behind bars, $65,000 in fines, and a nationwide ban on chaining dogs. Italy just passed one of the strictest animal protection laws in its history. Under the Brambilla Law, anyone who tortures or kills an animal faces up to 4 years in prison and fines up to $65,000, double the previous penalties. The law took effect July 1, 2025 and bans permanently chaining dogs outdoors across the country. For the first time, animals are recognized as legal subjects, not property. Organizing animal fights brings 2 to 4 years in prison. Puppy trafficking can mean up to 18 months. Filming animal cruelty online is now a crime, with harsher penalties if minors are involved. Abandoning an animal can cost up to $11,000. The Italian Senate passed it unanimously, and animal welfare groups across Europe are calling it a model for others to follow. 🇮🇹🐶

Perfect teamwork..🐕🐾🐈😅

Bro went from Joe Dirt to Enrique Iglesias. It’s like he refinanced his face with that hat.

The bumblebee queen learns how to use the protective cap in less than 24 hours.

"what radicalised you?"

I strive to be this level of unbothered

@7NewsMelbourne @georgia_bm_ In Australia, there is more punishment for a woman creating a female only space than there is for a man secretly filming 150 women in what should be a female only space.

How wonderful is this !

“He told police he was in the female toilets because “he wasn’t sure about his gender…” It’s literally the get out of jail free card for sexual predator men.

A while back, I learned something mindblowing about the geological history of the Mediterranean Sea, and I just can't get it out of my head. Now I'm going to make it *your* problem too. Sorry. Hang onto your hat. This gets wild. 1/

I guarantee you won’t be able to watch this without a smile on your face.

My Top Baking Tips!

@_allanmcconnell How good were they! Better than Oasis imo 😉

Pulp pretty damn magnificent tonight at the Sydney Opera House. Jarvis still has the moves, the looks and the vocal chops from 1996. Shouldn’t be allowed!

An amazing English font designed by Dmitry Lamonov.

@sciencegirl Sir

What would you name this cat

This is amazing Sydney Swisher is a self-taught painter who transforms thrifted fabrics into textured, memory-filled oil artworks that blend pattern and image.

He noticed a wild frog living in his fence post, so he built a 3D-printed home for the frogs to live and hide. 📹unknowndazza