أبو سعود
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أبو سعود
@1900_9o
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Dad's workouts may shape his child's endurance capacity and metabolic health. Not by passing on mitochondria—which come from mom—but by sending tiny sperm microRNA messages that tune early embryonic gene regulation. In a new study (mice), exercising fathers produced offspring with a higher VO2 max, greater endurance, a leaner body composition, and more mitochondria. They also had superior glucose control and insulin sensitivity when challenged with a high-fat diet. Effects tracked to sperm small RNAs that suppressed a "molecular brake" on PGC-1α, the classic mitochondrial biogenesis switch. This reframes preconception health as a two-parent story: mom supplies the mitochondria, but dad’s training status can still program how those mitochondria are used.

A life without sex takes a greater toll on men than on women. We investigated phenotypic and genetic correlates of never having had sex in ~400,000 UK residents aged 39 to 73 and ~13,500 Australian residents aged 18 to 89. Our results confirm findings from earlier studies that sexless individuals tend to be more educated and less likely to use alcohol and drugs. Phenotypically, there were notable associations with indicators of poor mental well-being, especially for men. Sexless men tended to suffer more from nerves, unhappiness, loneliness, and were less likely to believe their life is meaningful. There were also phenotypic associations of sexlessness with measures related to lower physical robustness, including low grip strength and lean arm mass, and an earlier age of wearing glasses. Common genetic variants explained 17% and 14% of variation in sexlessness in men and women, with a genetic correlation between sexes of 0.56. One possibility is that the same genetic variants predispose to both sexlessness and poor mental well-being. But the genetic correlation of sexlessness suggests this possibility is unlikely with regard to the affective traits in question. The genetic correlations of sexlessness with major depressive disorder and anxiety were negative, not positive. On the other hand, autistic spectrum disorder showed a substantial positive genetic correlation with sexlessness. Phenotypic and genetic correlations revealed links of sexlessness with less use of alcohol, cigarettes, and cannabis… It would be remiss to overlook the resemblance of this pattern to the stereotype of a “nerd”. medrxiv.org/content/10.110…










