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"Take your melatonin," they said. "It's natural," they said. A study presented at the American Heart Association's 2025 Scientific Sessions reviewed 5 years of health records for over 130,000 adults with insomnia. Half used melatonin for at least a year. Half didn't. The results: long-term melatonin users had a 90% higher chance of developing heart failure. They were 3.5 times more likely to be hospitalized for it. And twice as likely to die from any cause. The lead researcher said: "Melatonin supplements may not be as harmless as commonly assumed." Here's what bothers me from a metabolic standpoint. Most people taking melatonin nightly aren't dealing with a melatonin deficiency. They have a blood sugar problem. Their liver runs out of glycogen by 2-3am, cortisol and adrenaline spike to compensate, and they wake up wired. Or they're so sympathetically dominant from stress, undereating, or caffeine that their nervous system physically can't switch off. So instead of fixing the metabolic root, they suppress the symptom with a hormone. Nightly & for years. And now we're seeing what happens when you override your own hormonal signaling with exogenous melatonin long-term. This study is observational, but the pattern is hard to ignore. Before reaching for melatonin, try the basics: eat enough during the day so your liver has glycogen at night. Have a snack before bed, milk with honey, fruit with cheese. Get morning sunlight to set your circadian rhythm naturally. Address the stress and the undereating. Let the body make its own melatonin when the conditions are right.

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