Carol Nicholson

@Rainmaker1973 Anybody remember trump hurrying the scientists to come up with a vaccine and they tried telling him you cant rush it? But he insisted they do? Selective memory.

Scientists at Stanford Medicine have proposed an explanation for the rare cases of myocarditis that can occur after mRNA COVID-19 vaccination. The research points to a two-step inflammatory process involving the cytokines CXCL10 and IFN-gamma. According to the study, vaccine-activated immune cells, particularly macrophages, produce high levels of CXCL10. This molecule then stimulates T cells to release IFN-gamma, creating a potent inflammatory signal that can damage heart muscle cells. The team confirmed this pathway through experiments using human heart tissue models, immune cells, and mice. Importantly, blocking CXCL10 and IFN-gamma reduced signs of heart injury in laboratory models while largely preserving the protective immune response generated by the vaccine. The researchers also tested genistein, a natural compound found in soybeans, which showed anti-inflammatory effects in the models, though further clinical studies are required. Myocarditis following mRNA vaccination is very rare, occurring in approximately 1 in 140,000 people after the first dose and 1 in 32,000 after the second, with higher rates observed in young males. Most cases are mild and resolve with full recovery. The study notes that COVID-19 infection itself carries a significantly higher risk of myocarditis, roughly 10 times greater than vaccination. This work may inform the development of safer future mRNA vaccines while underscoring the established benefits of current ones in preventing severe COVID-19 outcomes. [Cao, X., et al. (2025). Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination. Science Translational Medicine, 17(828)]

@RyanCos78 @NFL_DovKleiman Wow. Right off the bat.

@NFL_DovKleiman Anything is possible when you have two white parents!!

Inspiring: Jahmyr Gibbs was adopted by Grey and Dusty Rose at 15 due to difficult family situations. Despite Gibbs facing many hardships throughout his early childhood, he is now one of the biggest stars in the NFL. Hats off to his adopted parents and grandmother. ❤️👏