Aaliyah Tyson

Fantastic news: our very own graduate student Aaliyah Tyson has been awarded a prestigious R36 NIDA Substance Use/Substance Use Disorder Dissertation Research Award. Many congratulations to this very well deserved recognition! @803Ast @NIDAnews

Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵 nature.com/articles/s4158…

Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: @USC @USCDornsife nature.com/articles/s4158…