tart

Lawyers are just engineers, but they have abstracted away the physical world into a notional one.

It's not that the sky is falling, or you should be a pepper, but you should be aware of the world around you.

Or that unwinding will take months. One of the prediction markets (I think it was Poly) interviewed a trader who discussed this topic. S/he thought prices were too low, given the time frame to restart flows and unwind.

If a time machine dropped me back into my first day as CEO, before I nearly lost everything twice, here's what I'd do differently: 1. I'd stop trying to be the best employee in my own company. The more valuable you are to your business, the less valuable your business is. 2. I'd build it like I was going to sell it, even if I never planned to. A sellable business is just a business that runs without you. 3. I'd install an operating system before I hired an operator, integrator, COO, or whatever you want to call them. No operating system, no operator. I learned that one the expensive way. 4. I'd document the 10-20 things that actually matter in my value creation process. Not 500 SOPs that nobody reads. Just the critical few. 5. I'd remind myself every single day that the goal isn't to build a team of rockstars. The goal is to build a company that doesn't require them. 6. I'd build a scorecard that mirrored and tracked the customer journey. Chasing vanity metrics has cost me a small fortune. 7. I'd set a 3-year target and execute in 90-day sprints. Annual planning is just New Year's resolutions for business owners. 8. I'd stop hiring "helpers" and start hiring functional leaders who own outcomes. Helpers make you busier. Leaders make you wealthier. 9. I'd fix my margins before I chased revenue growth. P&Ls lie. Cash doesn't. 10. I'd stop confusing a full calendar with a productive day. Busy isn't a strategy. 11. I'd stop swooping in to "save" things. Every rescue teaches your team to wait for you next time. 12. I'd resist the urge to start something new every time something old got hard. Complex breaks. Simple scales. 13. I'd fire problem clients (and problem business ideas) faster. They always cost more than they pay. 14. I'd have the hard conversations 6 months sooner. They never get easier, but the damage always gets worse. 15. And I'd remember that my kids don't want my money… they want my calendar. I didn't know any of this on Day 1. I learned it all the hard way. But you don't have to.

The company behind this pill has raised $250 million and is running the largest clinical trial in veterinary history, and the science explains why investors are losing their minds. The drug is LOY-002, made by a company called Loyal. It works as a caloric restriction mimetic. It tricks the dog's metabolism into behaving like it's on a restricted diet without actually reducing food intake. The biological cascade this triggers is the same one that's extended lifespan in every species ever tested, from yeast to primates. The FDA has already accepted the safety data and the effectiveness data. Two of three regulatory gates cleared. The third is manufacturing review, expected to complete this year. If approved, LOY-002 becomes the first FDA-approved drug for lifespan extension in any species. Not disease treatment. Not symptom management. Lifespan extension as a formal indication. The STAY study has 1,300 dogs enrolled across 70 vet clinics. Half get the pill, half get placebo. Both beef-flavored so nobody can tell the difference. It is the largest clinical trial ever conducted in veterinary medicine. Here's where it gets interesting for humans. Dogs develop the same age-related diseases we do: cancer, heart disease, kidney failure, cognitive decline resembling dementia. They live in our houses, eat similar food, breathe the same air. A mouse in a sterile lab tells you almost nothing about human aging. A golden retriever sleeping on your couch tells you a lot. Loyal has a second drug, LOY-001, targeting large breeds specifically. Big dogs die younger because centuries of breeding for size accidentally gave them elevated IGF-1 levels, which is the same growth hormone pathway linked to accelerated aging in humans. Reducing IGF-1 in flies, worms, and rodents extends lifespan. Loyal is now testing whether the same holds in dogs. 90 million pet dogs in 60 million US households. Average spending: $1,852 per pet per year. A pill that gives you two more years with your dog is the easiest sell in pharmaceutical history. Human longevity trials would cost $1 billion+ and take decades. Dog trials cost a fraction and produce data in years. Every dog in the STAY study is generating aging data that maps to human biology. The shortest path to an FDA-approved human longevity drug might run through your veterinarian's office.

Probably safer than evacuating it on the rail.

Monorail Teal spotted yesterday afternoon being tugged after a breakdown. Look close. Guests aboard. Many door windows removed for ventilation. @Blog_Mickey has an article describing this more: blogmickey.com/2026/04/monora…

Random Disney photo of the day!

A 7 year investigation of social science research found that only 1/2 of results could be replicated, and only 1/8 of data analyses could be reproduced. It’s now wiser to assume a social science study is flawed until there’s reason to believe otherwise. nature.com/articles/d4158…

@DisneyD23 @SethHendrix Wanna guess how effective THAT is?

@SethHendrix Sorry you’re having trouble purchasing tickets! For the fastest support, please visit support.d23.com to access helpful resources or connect directly with our D23 Guest Relations team.

Hey @DisneyD23 - your ticketing system sucks. I was put in the queue with 42,000 people ahead of me. I waited patiently for an hour until my turn finally came up. Then the page reloaded, timed out, and kicked me back down to #43145 in the queue again. What the actual hell.

Bye @MCO. See ya in a month

@Just_Curius Like Andor

They need to be wearing some sunglasses.

@SMB_Attorney Welcome to working for yourself. The bad news: work never sleeps. The good news: you get to decide when it naps. Also good news: your kids get to see what bigly adulting is about, and they learn that they can handle it. Also good news: they get a gigantic leg up on their peers.