Function

Function 🔙 Throw Back Thursday: Eaton at al. demonstrated that kidney-specific knockout of #Dmxl1 disrupted V1–V0 assembly, reduced proton pumping, and raised urine pH, supporting it as a mammalian #V-ATPase assembly factor. Read the full article ow.ly/qi7V50Ywwjl

Function 🔙 Throw Back Thursday: Eaton at al. demonstrated that kidney-specific knockout of #Dmxl1 disrupted V1–V0 assembly, reduced proton pumping, and raised urine pH, supporting it as a mammalian #V-ATPase assembly factor. Read the full article ow.ly/ToUs50YtBB6

Function | New Article Alert! 🚨2 weeks of time‑restricted feeding partially undid #HFD damage in mice. TRF improved daily metabolic rhythm, liver mitochondrial respiration, fat buildup, and mitochondrial injury — all without cutting calories. Read more ow.ly/qm3u50YvsC3

Function | Monday Insights ☕ Submit your #CircadianRhythm 🛌 work to Function's Circadian Biology: Timing Matters in #Physiology and #Pathophysiology collection. See the call: ow.ly/Fl8B50YqshS Read the collection: ow.ly/arlO50YqshR

Function 🔙 #TBT: The #WarburgEffect has puzzled scientists for ~100 years. This study offered a new quantitative explanation of #AerobicGlycolysis in #cancer metabolism—and proposed a framework for ATP synthesis and metabolite recycling. 10.1093/function/zqae008

Function | New Article Alert! 🚨This review examines how excessive alcohol use can damage peripheral nerves and increase pain sensitivity, and proposes #MitochondrialDysfunction as a key mechanism linking chronic pain and #AlcoholUseDisorder. Read ow.ly/f8ZM50Yrvbh

Function | Monday Insights ☕ New TOC-Volume 17, Issue 1-is now available! Thanks to the authors, reviewers, and editors who made this collection of new research possible. Explore the issue: ow.ly/gP2K50YqsvT

Function | Throw Back Thursday 🔙 #MoTrPAC generated a publicly accessible tissue #biorepository to support the study of temporal-, sex-, and age-specific responses to endurance exercise training in a #preclinical rat model. 🐀 Read more: ow.ly/hMbi50YmWRc

Function | New Article Alert! 🚨 Amatya et al. determined the utility of profiling the discarded plasma-derived #EV proteome combined with machine learning to predict #BronchopulmonaryDysplasia susceptibility risk in extremely #preterm infants. ow.ly/I9e250YoJZo

Function | Monday Insights ☕ Meet Editor David M. Pollock. A former President of APS and awardee of the AHA’s Louis K. Dahl Award, he now serves as EIC of Function-committed to broadening its scope and delivering rapid, fair decisions. Learn more ow.ly/Wiv650YmEz5

Function 🔙 Throw Back Thursday: Discover how pro-BDNF expression in #MuscleFibers may impact #neuroplasticity. 💪🧠 Read more: ow.ly/anb150YiZMF

Function 🚨 New Article Alert! Baily SM reviews the literature to examine the relationship between #alcohol, #CircadianRegulation, and #MetabolicDysfunction & #OrganInjury. 🍷🛏️🫀Read ow.ly/xINt50YiYsw

Function ☕ Monday Insights: Congrats 🎖️ to @edenmgallegos et al., for their #APSselect paper evaluating the effects of ethanol, sugars, and fats on hepatocyte #LipidMetabolism, #OxidativeStress, and #MitochondrialFunction in a spheroid model. Read ow.ly/syYX50YiYtK #MetALD

Comprehensive Physiology | Review Spotlight 🔦 This 2025 review highlights T2DM causes, comorbidities, and new therapies, plus a roadmap for future drug discovery. Read: ow.ly/c8ol50YcmSx #Type2Diabetes #DiabetesResearch #Physiology #Therapeutics #HealthyLifestyle

Today is the day! 🙂 Submit your abstract to the 2026 American Physiology Summit *before* the December 3 deadline ✅ ow.ly/M7F350XAEFz #APS2026 @APSPhysiology

🌟#APS2026 Abstract Portal is OPEN 🌟 Submit your best work to the American Physiology Summit by December 3, and we'll see you in Minneapolis in April: ow.ly/Mp5O50X9Rqy #WeArePhysiology @apsphysiology

🎉 Don't miss out on Function's newest issue! Check it out now! ow.ly/NL9t50WmJNJ.

Ready for #APS2025? We recommend adding this Publish with Purpose session to your schedule 🗓️ Saturday April 26 1:15 PM Strategies for Success: Engaging with @APSPublications Baltimore Convention Center PhysioHub Innovation Stage

Getting geared up for #APS2025? Add this Publish with Purpose session presented by @APSPublications to your schedule 🗓️ Friday April 25 1:15 PM From Poster to Paper: How to Publish with Purpose in @APSPhysiology Journals Baltimore Convention Center PhysioHub Discovery Stage

🔬In this original article from @AlbertaDiabetes, investigators identified #LMAN2 as a candidate regulatory protein that influences #redox-dependent modulation of Kv1.2. 🖱️Delve deeper: ow.ly/yqAX50Vo6YZ