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More from the non neoplastic bone marrow fascicle (arppress.org/books/book/71): Pelger-Huët syndrome (or anomaly) is due to mutations in the laminin beta receptor gene, which results in an abnormal nuclear morphology of segmented neutrophils (incidence of approximately 1 in 10,000 individuals). #HemePath

The answer is: patent foramen ovale (PFO)! The foramen ovale is patent throughout embryonic and fetal life in nearly all hearts. Premature (intrauterine) closure, by fusion of the valve to the limbus, may result in hypoplastic left heart syndrome. During the first year after birth, the same fusion process occurs in about two thirds of hearts and structurally closes the foramen ovale. In the remaining one third, functional closure is achieved because left atrial pressure exceeds right atrial pressure and thereby forces the valve against the limbus. This is different from an atrial septal sefect (ASD) which occur within the true interatrial septum (secundum type) or within neighboring structures that then result in an interatrial communication (primum, sinus venosus, and coronary sinus types). #CardiacPath #ThoracicPath

📚 The March Madness Sale is Here! We’re celebrating our biggest site-wide sale of the season. Now is the perfect time to shop. Save 30% on every single title in our collection. Visit: arppress.org Discount: 30% OFF site-wide Use Code: March30-on55i43s #pathology #pathologist #pathresident #pathx #pathtwitter

To round out the end of February, Congenital Heart Defect (CHD) month, here is our case of the month (from arppress.org/books/book/62)! Answer and discussion out tomorrow: Which CHD results from the failure to fuse the valve to the limbus of the fossa ovalis? #CardiacPath #ThoracicPath

More from arppress.org/books/book/71: Visceral leishmaniasis (caused by protozoan parasite Leishmania donovani) is endemic to the Mediterranean area, Africa, and South and Central Asia, and usually affects immunosuppressed patients. They are round, 1- to 3-μm organisms found both within histiocytes and extracellularly. #HemePath #IDpath

From arppress.org/books/book/71: Cryptococcus neoformans involves the bone marrow mainly in the setting of HIV infection, and may be the presenting manifestation with patients often presenting concurrently with meningitis and cytopenias. PAS shown here. #HemePath #IDpath

Let's dive into some wonderful images from the new Non-Neoplastic Disorders of Bone Marrow fascicle (arppress.org/books/book/71)! Crystal-storing histiocytosis is a rare reactive proliferation of histiocytes containing abundant crystallized immunoglobulin inclusions (highlighted by PAS), seen in plasma cell myeloma, MGUS, and (less commonly) B-cell lymphomas. #HemePath

Our newest release, Non-Neoplastic Disorders of Bone Marrow, is officially here! Go to arppress.org to grab your copy! This Fascicle fills this gap for practicing pathologists and trainees by illustrating the distinct morphologic characteristics and practical approach to the broad spectrum of benign blood and bone marrow disorders. #Pathology #Hematology #Pathx #MedicalStudent #ResidentLife #Pathologist

You all are spot on! The correct answer is PAPILLARY CARCINOMA, INVASIVE ENCAPSULATED FOLLICULAR VARIANT. The first image demonstrates this encapsulated tumor is composed of follicles throughout and displays a focus of mushrooming capsular invasion (top). The second image demonstrates cytomorphology at higher magnification, and vascular invasion in the form of a tumor thrombus hanging in the lumen of an intracapsular vessel.

What is your diagnosis? (FV-PTC = follicular variant PTC)

We're rounding out January with a special Case of the Month in honor of thyroid awareness month. See the images and poll below and test your knowledge! Answer and discussion out tomorrow. #EndoPath #HNPath #ThyroidAwareness

More from arppress.org/books/book/70: Pemphigus foliaceus is an intraepidermal autoimmune bullous disorder characterized by flaccid bullae and crusted plaques, histologically showing superficial epidermal acantholysis involving the granular cell layer, with blister formation and subsequent erosions. #DermPath

More from the non-neoplastic skin fascicle (arppress.org/books/book/70): Fox-Fordyce disease (apocrine miliaria) is an eruption affecting the apocrine glands (axillae, pubis, periareolar region, genitalia) consisting of small dome-shaped papules. Histologically, the apocrine glands are dilated with retention of secretions, and attached hair follicles commonly display follicular hyperkeratosis and perifollicular lymphohistiocytic inflammation. #DermPath

New year, new fascicle to show off! From our new series 5 fascicle "Non-Neoplastic Disorders of the Skin" (arppress.org/books/book/70): Perforating folliculitis is the transepidermal elimination of the hair follicle (+/- collagen or elastic fibers), which presents as pruritic umbilicated papules and plaques. #DermPath

More from arppress.org/books/book/69: Malignant melanotic nerve sheath tumor (MMNST; previously called melanotic schwannoma) has a propensity to arise in association with spinal roots and ganglia, and consists of spindle to epithelioid cells arranged in sheets or lobules with variable melanin accumulation. #NeuroPath

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Equip your practice for the new year with a full year of ARP Digital Access. Use those remaining 2025 resource budgets and save lock in the 2025 rates + $50 off 🔬 ✅ $50 OFF Individual Access (Price as marked) Prefer Print? ✅ 30% OFF Fascicles with code: ARP2025-jkjvutwu Get the gold-standard reference for your practice at the best possible value. ⏳ Offer ends December 31st! Shop Now: Individual Access 🔗 arppress.org/collection/718… Fascicles at 📚 arppress.org #Pathology #PathTwitter #SurgicalPathology #MedicalBooks #pathologists

More on meningiomas from arppress.org/books/book/69: Some striking subtypes of meningioma include: psammomatous, angiomatous, and secretory. #Neuropath

From arppress.org/books/book/69: Meningiomas are well-circumscribed, extra-axial, dural-based masses, and are the most frequent primary CNS tumors reported (in the US). The prototypical subtype is termed meningothelial and is composed of syncytial cells with overt whorl formation. #NeuroPath

As the year draws to a close and the holiday season is in full swing, we extend our warmest wishes to you and your family. Year-End Sale Alert! Save 30% on All Fascicles Use the code ARP2025-jkjvutwu at arppress.org. #pathology #pathologist #pathx #pathtwitter