ATVB: An AHA Journal

Featured Article: Bmal1 is a novel regulator and target for vascular calcification in diabetes, via a non-canonical circadian pathway mediated by Runx2 transcriptional activation ahajrnls.org/4sMQdhV

Editor Pick: Sleep-related disorders may affect vascular and myocardial dysfunction, hypertension, insulin sensitivity and glucose metabolism, lipid metabolism and weight gain and thereby impact cardiometabolic risk. ahajrnls.org/4m8RUE2

The structural diversity of HDL particles drives their cardioprotective functions. This review explores how biogenesis and remodeling influence HDL's role in cholesterol transport. ahajrnls.org/48kT2OW

New brief review explores emerging evidence on CVD risk linked to the multiple dimensions of sleep, and wearables as tools for assessment @DineshKalra @DrSpaulding_PhD @NinoIsakadze @gwilson_md @SethShayMartin ahajrnls.org/4m1DmWB

Inui et al. review the importance and therapeutic potential of efferocytosis in the heart. ahajrnls.org/40YBvbz

Analysis of 3 studies reveal pathways between psychosocial factors, plasma proteins, and heart disease. Read about how stress may alter proteomic profiles here @DrLekkiWood @LaShauntaGlover @UtahirMD @DrDanKatz ahajrnls.org/4bT5rea

This study identifies MMP-driven ECM degradation as the mechanism behind lymphatic valve loss in lymphatic malformations with activating KRAS mutations. ahajrnls.org/4t8ev5L

FGFR2 splicing promotes vascular aging and atherosclerosis progression through an FGF2-FGFR2-IIIc autocrine loop ahajrnls.org/4szhX9S

Endothelial cell mitochondrial enzyme identified as new target for treating aortic dissection through mice studies ahajrnls.org/4sP0Pgx

How does exercise protect the aorta? New research identifies the RUNX1-PDE5A pathway in vascular muscle as a key mechanism, suggesting new strategies for aortic dissection prevention ahajrnls.org/4doraNB

New study in GPIHBP1 null mice shows hypertriglyceridemia does not worsen thoracic aortic aneurysm and dissection, unlike abdominal aortic aneurysm ahajrnls.org/41etSxE

Endothelial calcium signaling and cation channels contribute to cellular senescence and inflammasome activation in pulmonary hypertension ahajrnls.org/4dDeHFw

We reveal how CAD-risk gene ZC3HC1 controls smooth muscle cell phenotypes and neointima formation, offering insight into genetic risk mechanisms and targets for vascular therapy @Vascular_Prot @JeanetteErdmann @mete_civelek ahajrnls.org/3Pfi0sC

Featured Article: Investigating effective antithrombotic therapy for antithrombin resistance, a novel thrombotic predisposition, using an original mouse model. ahajrnls.org/4lvf0Vb

MR black-blood cine quantifies carotid wall dynamics linked to cap rupture and plaque phenotype ahajrnls.org/4uC4RKs

Featured Article: Elimination of uPA activity delays the development of obesity and metabolic syndrome –therapeutic implications for obesity and metabolic syndrome ahajrnls.org/46ipXme

Editor Pick: In aortic smooth muscle cells, type 2 diabetes induces phenotypic switching via altered gene expression and chromatin accessibility. Strikingly, this profound hyperglycemic memory is not reversed by the antidiabetic drug Dapagliflozin, whic... ahajrnls.org/4bc0EoS

Look out for our upcoming review on the effects of sleep disordered breathing on cardiometabolic outcomes in the influential journal, ATVB @rahulgomez101 @AtulMalhotra13 ahajrnls.org/3P2Zkw2

Large-scale international data show no increased CV risk with strong vs. weak CYP2C19-inhibiting PPIs in clopidogrel users, clarifying a long-debated concern ahajrnls.org/4b3jdf7

ELABELA limits aortic dissection by maintaining VSMC homeostasis and regulating NETosis. A novel therapeutic hope! @Aidong ahajrnls.org/4cI9lbX