Abhijith Radhakrishnan

Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release | Nature Communications nature.com/articles/s4146…

4Pi-SMS and pan-ExM reveal, in a close collaboration with the Rothman lab, a surprising tetraplex organization and self-assembly of rim golgins, which we believe can explain stack formation of the Golgi apparatus: biorxiv.org/content/10.110…

Please check out recent work on the golgin family of proteins and its potential role in the organization of Golgi

Dynein is dynamic, dynein is 'naughty', dynein is everywhere in cells, but too hard to capture their conformations due to the extreme flexibility. By leveraging the real power of cryo-EM for dynamic structural analysis, we reveal a whole series of intermediates states of full-length human dynein-1 on and off microtubules: biorxiv.org/content/10.110…

Excited to share our latest paper in Advanced functional materials @AdvSciNews, from the Ramakrishnan lab @dR_sathish_Lab, on a rapid way to isolate highly pure extracellular vesicles using photosensitive nanoprobes @YaleMed @yalepathology @YaleWestCampus onlinelibrary.wiley.com/doi/full/10.10…

🔬 Just published a groundbreaking paper on reconstructing synapse architecture on a chip - a true engineering marvel! 🚀 Beyond thrilled to be part of such an incredible team. A way to dissect the mysteries of a synapse! 🧠✨ doi.org/10.1073/pnas.2… #NeuroEngineering

Celebrating the end of an amazing era of ⁦@YaleCellBio⁩ ⁦as our Chair Jim Rothman steps down. He built our department into a thriving, collegial, and collaborative mecca founded on the bedrock importance of asking fundamental biological questions. He will be missed.

Incredible job by my colleagues, deciphering the long-time enigma of how many SNARE complexes are under each Ready-Release Vesicle. #Neuroscience #ResearchProgress #biophysics biorxiv.org/content/10.110…

Making progress on our insect milk protein project - identifying residues that control fatty acid binding. #PLOSONE: Variability in phenylalanine side chain conformations facilitates broad substrate tolerance of fatt ... dx.plos.org/10.1371/journa…

What a great way to end the year! Our article is on the cover! @YaleWestCampus @yalepathology

I'm thrilled to see the first paper from our lab published in Small onlinelibrary.wiley.com/doi/10.1002/sm…… and featured on the advanced science news (advancedsciencenews.com/visualizing-ce…) @AdvSciNews @Yalepathology @YaleWestCampus @YaleCellBio #smFRET #membraneonchip

We have made some inroads in deciphering the molecular mechanism of asymmetric cell division in mycobacteria @Rego_Lab. The paper is finally out in @eLife. Happy to share this fundamental piece of work.

This is happening today @YaleMed - Xiaowei Zhuang gives the Palade Lecture!

Signaling nucleotides in bacteria sciencedirect.com/science/articl…

New approach could be used to build eco-friendly refrigerators and air conditioners physicsworld.com/a/solid-state-…

The Rothman lab at Yale are looking for a motivated Postdoctoral Associate with experiences in imaging or phase separation to work on organization of Golgi apparatus. We are using 4pi cutting-edge super-resolution imaging as well as in vitro reconstitution...(1/3)

Excited to share our new study with the Müller and @SchullerJm labs, online @nature: nature.com/articles/s4158… This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of the enzyme HDCR 🍩 1/🧵

A bunch of tomo developers and users have "enabled me" to understand tomography data, metadata and "talk to" very cool tomography software. doi.org/10.1016/j.jsb.…. Congrats to all!. I'm still in beta though, not publicly available to avoid you unnecessary suffering. #teamtomo

An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria biorxiv.org/content/10.110…

Check out our new paper on fluorogenic #DNAPAINT! Our new probe design allows two-color DNA-PAINT imaging 26x faster without optical sectioning. rdcu.be/cMygl @bewersdorflab @YaleCellBio @YaleWestCampus @YaleMed @naturemethods