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📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
pnas.org/doi/10.1073/pn…
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism
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The Aging Brain Lab
20 posts
The Aging Brain Lab
@AgingBrainLab
Barron lab @NTU_LKCMedicine @NTUsg Neuroscience lab studying #mitochondria #metabolism #microglia #aging and #Alzheimers
Singapore Katılım Mayıs 2020
178 Takip Edilen104 Takipçiler
The Aging Brain Lab retweetledi
Breaking boundaries in neuroscience! 🧠 Asst Prof Anna Barron (@AgingBrainLab), our new EMBO Global Investigator, explores mitochondria's role in brain health. Despite pandemic challenges, her commitment to knowledge remains unwavering.
Learn more: embo.org/people/putting…
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The Aging Brain Lab retweetledi
Putting mitochondria on the map: learn about new EMBO Global Investigator Anna Barron and her research on cellular metabolism as a regulator of microglial fate and function
embo.org/people/putting…
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What a great end to 2023! Very excited to join the EMBO Global Investigator network and looking forward to the new opportunities it brings!
EMBO@EMBO
Ten life scientists are welcomed to the EMBO Global Investigator Network, which provides access to the EMBO networking and training activities embo.org/press-releases…
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The Aging Brain Lab retweetledi
Excited to share our Review Article published in Journal of Neuroinflammation where we discuss key mechanisms contributing to lysosomal acidification dysfunction in microglia. bit.ly/3DFzaXn Great collaboration with @JialiuZeng @jiahui_w20 @AMBarroness @AgingBrainLab!
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Read more about our latest work here doi.org/10.1073/pnas.2…
NTU Singapore@NTUsg
💊 #NTUsg scientists may have found a way to spur brain immune cells into clearing toxic waste linked to #Alzheimers disease. This breakthrough could provide new possibilities for developing new drugs targeted at Alzheimer's disease. @NTU_LKCMedicine bit.ly/NTUsg-metaboli…
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The Aging Brain Lab retweetledi
Study shows new way to spur brain #immunecells to clear toxic waste linked to #Alzheimer'sdisease @PNASNews doi.org/grtbjj medicalxpress.com/news/2023-03-s…
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💡Congratulations to lead authors @LaurenHFairley1 @KeiOnnL @jiahui_w20 and collaborators including @AnselmVincent @SarahRLangley @gdagstn
🧵 (7/7)
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To restore the immune cells’ clean-up function 🧹, we “switched off” glycolytic metabolism by removing hexokinase-2 bound to the mitochondria.
This spurred microglia to gobble up 🍽️ toxic proteins that can build up in the brain 🧠 leading to Alzheimer’s.
🧵 (6/7)
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📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
pnas.org/doi/10.1073/pn…
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism
English
Latest work from the lab. Mitochondrial control of microglial phagocytosis in Alzheimer’s disease doi.org/10.1101/2021.1… @LaurenHFairley1 @KnockOutinLab
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Our latest paper is out! Congratulations @LaurenHFairley1 !
Dr Lauren H. Fairley@LaurenHFairley1
Thrilled to share our recently accepted paper on the therapeutic effects of #TSPO in a model of tauopathy. @BioMedCentral @AMBarroness @AgingBrainLab @NTU_LKCMedicine @WomenAtNTU @alzassociation jneuroinflammation.biomedcentral.com/articles/10.11…
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The Aging Brain Lab retweetledi
Excited to share our new article "Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease" @FrontImmunol @AgingBrainLab @NTUsg @WomenAtNTU @AMBarroness Jia Hui Wong
doi.org/10.3389/fimmu.…
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The Aging Brain Lab retweetledi
Our new paper out showing that the mitochondrial translocator protein is critical for brain steroidogenesis link.springer.com/article/10.100…
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The Aging Brain Lab retweetledi
Visualizing damaged mitochondria in Alzheimer’s mice authors.elsevier.com/c/1bKkH_4VLjX0…
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The Aging Brain Lab retweetledi
Genetically targeted reporter imaging of deep neuronal network in the mammalian brain biorxiv.org/content/10.110…
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