Alex Dowell

65 posts

Alex Dowell

Alex Dowell

@AlexD_81

Research Fellow, Uni of Bham, UK. Immunology, virus and cancer.

Katılım Şubat 2012
130 Takip Edilen24 Takipçiler
Alex Dowell
Alex Dowell@AlexD_81·
@dgurdasani1 Consider WHEN this study was run, ie Mid-2021, not yesterday. Protocol probably written early 2021. What was known/accepted about long-COVID then? Does it seem wise to do now, probably not. Would it even be possible, no. Is it incredibly valuable data, undoubtedly!
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Dr. Deepti Gurdasani
Dr. Deepti Gurdasani@dgurdasani1·
This was the information provided to participants- almost no mention of long COVID, and the fact that it's not uncommon at all. Only a statement that one should not participate if they depend upon their sense of smell!
Dr. Deepti Gurdasani tweet media
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Maini Lab UCL
Maini Lab UCL@maini_lab·
Massive congratulations to @Leo1401j for his Wellcome Career Development Award...a whole EIGHT years of funding to expand his fantastic research group @iit_ucl 🤩👏🍾🥂🍾
Maini Lab UCL tweet media
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Alex Dowell
Alex Dowell@AlexD_81·
@1979HAB @mgh1029 @STVNews Asks for source, gets source, replies with a meme, good argument. Another fun stat, 100% (i.e all) of people born before the smallpox vaccine was available died!
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STV News
STV News@STVNews·
No cervical cancer cases have been detected in women who have been fully vaccinated against HPV, Public Health Scotland has revealed. i.stv.tv/48ZbmLB
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Alex Dowell
Alex Dowell@AlexD_81·
@dgurdasani1 We just finished test, kids when they see yet another new (to them) CoV, 50% don't know they have it the other 49.9% (ish) sniff/cough few days. What happens to adults, bad things! until we provide workout in the form of Vacc, immunity needs to develop in kids as evolved to do
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Dr. Deepti Gurdasani
Dr. Deepti Gurdasani@dgurdasani1·
These arguments make no sense, and to my knowledge zero evidence has been provided to back these up. Surely, the take away should be that so much of disease in children and families (yes, children live in families!!) is avoidable, and we should try to prevent this.
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Dr. Deepti Gurdasani
Dr. Deepti Gurdasani@dgurdasani1·
There's no evidence that early blanket exposure to all resp viral pathogens is good- in fact for almost all viral disease mortality/hosp in under 5s is greater than in older children. Why are we so keen to expose children with no evidence of benefit, but clear evidence of risk?
Nate Bear@NateB_Panic

Yesterday a Guardian story about record pupil absence in the UK once again repeated debunked misinformation about children being sick more because of a lack of exposure to viruses. Guardian editors don't seem to be getting it, so let's debunk it again 🧵

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Alex Dowell
Alex Dowell@AlexD_81·
@stellacreasy Using the tragic death of a baby that had greater than 95% chance of survival for your own political gain is low, have you considered being a conservative? There was literally 6 months that abortion was an option
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stellacreasy
stellacreasy@stellacreasy·
The average prison sentence for a violent offence in England is 18 months. A woman who had an abortion without following correct procedures just got 28 months under an 1868 act- we need urgent reform to make safe access for all women in England, Scotland and wales a human right.
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Alex Dowell
Alex Dowell@AlexD_81·
@DuntonRosalind @1goodtern We want to keep kids safe but if we mitigate against infection in childhood there would be an ever increasingly vulnerable population, not just to COVID, but all others infection too. First exposure later in life would just result in far worse outcomes.
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Rosalind 💙
Rosalind 💙@DuntonRosalind·
@AlexD_81 @1goodtern We were definitely trying to come up with a vaccine against RSV in kids pre 2020, so it was definitely recognised as a problem & still is. We need to strive to keep doing better for our kids not worse. RSV can leave lasting damage/make kids more susceptible to asthma & other infs
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tern
tern@1goodtern·
WHY IS THIS NOT ON EVERY BRITISH NEWS CHANNEL? Covid Admissions for under 5s in England: 2020: 1629 2021: 5353 2022: 13006 🚀 2023: ?
tern tweet media
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Alex Dowell
Alex Dowell@AlexD_81·
@DuntonRosalind @1goodtern Yes there were, COVID probably helped development. Wasn't minimizing RSV, I was meaning we shouldn't inflate COVID to be a boogeyman. We lived with RSV, if 60% of 0-5yrs saw RSV first time in 1yr I'd guess hosp rate would be higher than COVID.
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Alex Dowell
Alex Dowell@AlexD_81·
@duolingo sorry to hear, given up after +1yr, feel free to roll back the horrible update and I'll be back, until then tìoraidh an dràsta
Alex Dowell tweet media
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Alex Dowell
Alex Dowell@AlexD_81·
@Simon7Holmes @Anto_Berto @ShamezLadhani and in large population studies of COVID vaccines there has been NO indication for ADE. Our study highlights T may be associated with reduced (symptomatic) infections, which follows in depth studies in adults showing similar effects of some T responses in adults. 2/2
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Alex Dowell
Alex Dowell@AlexD_81·
@Simon7Holmes @Anto_Berto @ShamezLadhani Antibody dependant enhancement (ADE) was suggested as a theoretical problem, mainly due to results from one study of a different type of coronavirus (before COVID) in animals using a specific type of inactive vaccine. No other study has reproduced this 1/2
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Antonio Bertoletti
Antonio Bertoletti@Anto_Berto·
Very interesting work of @ShamezLadhani and colleagues. Kids with Spike-T cells but without antibody protected from Omicron Infection( I suppose symptomatic). One other evidence despite small sample size that immunity is not only antibodies. We evolved to have both. Go T cells
Bertoletti Lab@bertoletti_lab

Interesting study showing that Spike-T cells associate with protection from Omicron infection in children (4-11 years old). The limitation is the small cohort size, but the data are quite impressive: go T cells! ja.ma/3N9DxOb via @JAMAPediatrics part of @JAMANetwork

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Dr. Deepti Gurdasani
Dr. Deepti Gurdasani@dgurdasani1·
@karamballes @ShamezLadhani Many of us who follow the global evidence on this have been saying for a year or more that children don’t mount antibody responses in the way adults do. And numerous studies showing antibody response more robust with vaccines in children.
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Alex Dowell retweetledi
Shamez Ladhani
Shamez Ladhani@ShamezLadhani·
1/ Our preprint on immune responses of kids to #SARSCoV2 #Omicron is online Top line: Primary Omicron infection induces poor antibody responses in unvaccinated kids, but robust T cell responses which will protect against severe #COVID19 in the future🧵 👉biorxiv.org/content/10.110…
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Alex Dowell
Alex Dowell@AlexD_81·
@dgurdasani1 @karamballes @ShamezLadhani Excuses me, you have picked data. You have omitted our previous NAT Immunol study showing children make good antibody responses. In both cases we used the MSD platform, which has been used in the PITCH studies and ChAdOx1 trial. note MSD tested against Roche, 100% concordant.
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Alex Dowell
Alex Dowell@AlexD_81·
@dgurdasani1 @karamballes @ShamezLadhani Excuses me this is misleading, you seem to have cherry picked data. You omitted our prior Nat Immunol study. Showing children make good antibody response to pre-Omicron variants. We used the MSD platform, as used in PITCH and the ChAdOx-1 trial, from which you have quoted. Also
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Alex Dowell
Alex Dowell@AlexD_81·
@ShamezLadhani Good to know all those pre-2020 nursery bugs were worth while! HCoV maybe, but I wonder perhaps just the bulk of infection enhancing 'trained' innate response, better primed mucosal immunity like in kids, might be suggested when effect is lost with older children
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Shamez Ladhani
Shamez Ladhani@ShamezLadhani·
Isn’t this interesting?! Adults w/out kids had 15%⬇️ #covid19 but 49%⬆️ hospitalization & 76%⬆️ ICU than adults with 0–5y kids. Authors suggest seasonal coronavirus exposure from kids might ⬇️ severe covid - yet some still want to keep kids isolated…🤷🏻‍♂️ 👉pnas.org/doi/10.1073/pn…
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Professor Alex Richter
Professor Alex Richter@AlexRichter3·
Big birthday today! Lots to reflect on and also lots to look forward too.
Professor Alex Richter tweet media
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Alex Dowell
Alex Dowell@AlexD_81·
@fitterhappierAJ Where's the control for other proteins? Bathing cells in 50ug/ml protein, not really physiological... And choosing a concentration to study inhibition based on a titration with inhibition as the read out... a bit tautological!
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AJ Leonardi, MBBS, PhD
AJ Leonardi, MBBS, PhD@fitterhappierAJ·
Yet another way SARS Cov 2 escaped from T cells It disrupts the Immune synapse, how a T cell interfaces with an infected cell Stop using peptide stims and saying they represent T cell control of SARS Cov 2 biorxiv.org/content/10.110…
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Alex Dowell
Alex Dowell@AlexD_81·
@dgurdasani1 In Aug ~50 attend hospital, daily rate ~50000, now ~150 attend, but daily rate +4x higher. Surely reflective of increased cases, not severity. Also no info on preexisting conditions, nor granularity of age ie <1yr higher rate of attend for a lot of resp virus
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Alex Dowell
Alex Dowell@AlexD_81·
Don't understand rational, surely aSy where likely hood of false POS is highest is exactly where PCR should confirm. Sympto even if not Covid still not bad to isolate. Surely this just risks healthy people being stuck at home, making short staffing worse!
Hugh Pym@BBCHughPym

UKHSA has confirmed that the requirement for asymptomatic people testing positive on lateral flow to do confirmatory PCR will be suspended - from Jan 11 in England - devolved administrations possibly sooner.

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Keşfet

@dgurdasani1 @wellcometrust @sangerinstitute @Cambridge_Uni @maini_lab @Leo1401j @iit_ucl @1979HAB