Alice B. Popejoy, PhD

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Alice B. Popejoy, PhD

Alice B. Popejoy, PhD

@AlicePopejoy

Public Health Genetics PhD; Stat/Pop Gen. Computational evolutionary genomics and diversity. Ethical, legal, and social implications (ELSI). Black Lives Matter.

UCDavis Public Health Sciences Katılım Mart 2016
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
Thanks so much @GenomicsNZ and @CartneyAnn for hosting me (and @NanibaaGarrison) yesterday. It was an honor to present our work on the embedded ELSI team of the US @HumanPangenome project. Our key question for you (and now Twitter): What makes a research partner TRUSTWORTHY?
GenomicsAotearoa@GenomicsNZ

REMINDER: Today's Genomics Aotearoa Seminar is at 10am, as we have international speakers Dr Alice Popejoy and Dr Nanibaa’ Garrison talking about the Human Pangenome Reference Consortium🌏🧬 See you in a few minutes!

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ELSIhub | CERA
ELSIhub | CERA@ELSIhub·
"Humanity’s genetic variability cannot be captured simply by sequencing the genomes of more people." CERA co-directors @mildredkcho and @sandrasoojinlee call for the HPRC to invest in interdisciplinary teams committed to equitable collaboration. nature.com/articles/d4158…
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
@DocEdge85 Osaka-ya in Sacramento has unbelievably good shaved ice. We also have Gunther’s fruit freeze, which is like shaved ice made with frozen fresh fruit w/out the added syrup. Worth a trip?
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Doc Edge
Doc Edge@DocEdge85·
Is there a reason why no one in the continental US can make a good shave ice?
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ELSIhub | CERA
ELSIhub | CERA@ELSIhub·
The lack of diversity in human genomics research and reference datasets is a problem, with real-life consequences, but the path forward remains elusive. Explore our latest ELSIhub Collection: How Do We Diversify Human Genomics Research? from @AlicePopejoy elsihub.org/collection/how…
ELSIhub | CERA tweet media
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
Yikes! I wonder what part(s) of my genome encode social privilege, and those amazing mentoring relationships that helped me realize my potential as an academic researcher…? Holy hell we need to wake up and smell the wishful thinking amidst wafts of putrid familial confounding.
Tobias Wolfram@_twolfram

1/ Excited to share our new #GWAS preprint on the genetics of occupational status using data from @uk_biobank that finally completes the genomic SES-triad of Education, Income, and Occupation! Find the preprint here: biorxiv.org/content/10.110… 🧬📊👩‍🏫👨‍🔧👩‍💼

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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
@ikingjordan @thebirdmaniac @DialecticBio À la Dobzhansky: we agree ✨ « Conflating these two distinct and independent concepts – human genetic diversity [genomic information] and equality [to which we now often refer as ‘diversity/equity/inclusion’ & measure by race/ethnicity] is a category error that is best avoided. »
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King Jordan
King Jordan@ikingjordan·
@AlicePopejoy @thebirdmaniac @DialecticBio Theodosius Dobzhansky may have said it best “… diversity is an observable fact of nature, while equality is an ethical commandment.” Conflating these two distinct and independent concepts – human genetic diversity and equality – is a category error that is best avoided.
King Jordan tweet media
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dialecticbio.bsky.social
dialecticbio.bsky.social@DialecticBio·
This modified PCA plot (left) is consistently reposted by racists. The implication being that Africans were isolated & evolving into a separate species. This is false. The lack of "continuum" is an artefact of sampling, as seen by recent PCAs (right) researchallofus.org/wp-content/the…
dialecticbio.bsky.social tweet mediadialecticbio.bsky.social tweet media
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
@ikingjordan @thebirdmaniac @DialecticBio Now, of course, the argument that there is no connection between common, global genomic variation and race categories is empirically demonstrable. Not to be confused with the connection between genetic ancestry and genomic variation. Ancestry is relative, as are population means.
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King Jordan
King Jordan@ikingjordan·
@AlicePopejoy @thebirdmaniac @DialecticBio I def respect your efforts in support of more equitable genomic medicine. But staking our claims to human equality and social justice on readily falsifiable empirical grounds – eg socially defined race and genetic ancestry are distinct and unrelated – ultimately undermines them.
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
@ikingjordan @thebirdmaniac @DialecticBio I’ve not heard claims of NO relationship between race categories and genetic ancestry categories. What is perhaps misunderstood (as such) is an appeal for us to examine how race-based typologies drive the construction of broad ‘ancestry’ groups w/ DNA data reduced to 2D clusters.
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King Jordan
King Jordan@ikingjordan·
@thebirdmaniac @DialecticBio My concern is that denying obvious genetic differences between socially defined racial groups (1) compromises our scientific integrity and (2) will hamper efforts to ensure that the benefits of genomic medicine are equitably shared among all people. nytimes.com/2018/03/23/opi…
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Joanna Karolina Malinowska
Joanna Karolina Malinowska@jk_malinowska·
Our new paper (Malinowska & Żuradzki @incet_uj) is now published in OA: link.springer.com/article/10.100… We reconstructed the theoretical background assumptions about racial ontology which researchers implicitly presume in their studies with the aid of a sample of recent papers...
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
@CartneyAnn Don’t give up! Despite most mentors telling you to get into a box and to stay there until you get a “real job”, in truth, the only folks who are sure never to get a faculty job are those who stop trying. @ucdavis is interdisciplinary by design, so that is considered a strength!
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Ann Mc Cartney
Ann Mc Cartney@CartneyAnn·
Is it possible to be an Assistant Professor of General Science? When I look at position titles they seem focussed on a single discipline. My transdisciplinary skillset does not really fit this model. Always feeling like an imposter in academia 🥲.
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Alice B. Popejoy, PhD
Alice B. Popejoy, PhD@AlicePopejoy·
“Perhaps the most long-standing failure within genomics research is the lack of studies in populations of non-European ancestry, mirroring the systemic bias in biomedical research and society at large.” TY @genandgenes for dropping much-needed truth bombs, as usual!
Genevieve Wojcik, PhD MHS@genandgenes

As a preview for the recent Global Biobank Meta-analysis Initiative (GBMI) pubs, I wrote an epidemiologist's bingo card of: 🪐Why sample size matters (or doesn't) ✨How we're doing better on diversity (or aren't) 🏔What "tall" data will offer (or won't) authors.elsevier.com/a/1fzsZL7PXiqT5

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Dr. Dr. Desi (she/her)
Dr. Dr. Desi (she/her)@native4data·
Riddle me this: if one is hired as part of an Indigenous diversity cluster & after it comes to light that you aren’t in fact an Indig person as you’ve claimed & you built a career on this lie, what happens? At a public land grant institution on tribal lands? This isn’t made up.
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Keşfet

@ASU @asuSOLS @ASUSST @sandrasoojinlee @DocEdge85 @ucdavis @HumanPangenome @ikingjordan