Ann Bauer Sc.D.

Statement on the prenatal #acetaminophen (#Tylenol, #paracetamol use & offspring neurodevelopment (#ADHD, #autism) research from my co-author, Dr. Andrea Baccarelli, Harvard Dean of Public Health:

"Regression is a common symptom in ASD, and specifically in boys, confers higher severity of ASD symptoms." It isn't normal for children to regress/lose skills. Research needed into WHY this often occurs in autism (underlying biology). sciencedirect.com/science/articl… via @PaulWhiteleyPhD

Advances in brain imaging, DNA sequencing and molecular biology are revealing remarkable overlaps between autism and Alzheimer’s, scientists say. wapo.st/3OocxiW

Makes you wonder if there aren’t some overlapping environmental causal factors. pubmed.ncbi.nlm.nih.gov/37633120/ pubmed.ncbi.nlm.nih.gov/41118120/ pubmed.ncbi.nlm.nih.gov/38039689/ pubmed.ncbi.nlm.nih.gov/24350947/

“What’s emerging from this and other research labs is not just a shift in thinking, but the early outlines of new treatments.” washingtonpost.com/health/2026/04…

Check out the #Autism Innovation Coalition Leading scientists, clinicians, & policy advocates working together to uncover the biological mechanisms that drive autism-redefining understanding & care through systems biology, precision medicine & innovation autisminnovationcoalition.com

A systems biology framework—one that considers cellular metabolism, including signaling pathways, redox balance, and mitochondrial function, alongside the dynamic interplay among reciprocally regulating body systems such as the immune system—is crucial to advancing autism research. As researcher Robert K. Naviaux and others have emphasized, diverse genetic and environmental factors may converge on disruptions in cellular metabolism, resulting in systems-level dysfunction across the body. Historically, autism research has focused primarily on the brain. However, the high rates of co-occurring medical conditions, together with multiple converging lines of evidence, increasingly suggest that for at least some cohorts, autism may involve whole-body pathophysiology rather than isolated neurodevelopmental differences alone. Expanding research efforts to include underlying systems biology therefore represents an important complement to existing lines of investigation. This paper is a tour de force and underscores that perspective. pubmed.ncbi.nlm.nih.gov/41242673/ Visit the Autism Innovation Coalition for more of these perspectives. autisminnovationcoalition.com

@FogelSylvia @katiewr31413491 @JillEscher Over & over again: neurotoxins impair brain development & IQ. The earlier in life children are exposed to neurotoxins, the greater the destructive impact on their brain development is going to be. It’s willful ignorance, not rocket science. youtu.be/E6KoMAbz1Bw?si…

Side stepping the autism debate, when I hear a doctor state that Tylenol is extremely safe it tells me they weren’t paying attention to their toxicology lessons. Arguably, THE most toxic OTC medication. Common cause of liver injury and depletes glutathione. Even at the proper dose it causes mild toxicity. Every toxicology textbook highlights this.

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ICYMI too: Maternal prenatal paracetamol (#Tylenol) ingestion & scholastic attainments of the offspring Maternal exposure is associated w/ disadvantages to the offspring in scholastic abilities such as mathematics & reading at secondary school ages pubmed.ncbi.nlm.nih.gov/38149049/

Sex-dependent effects of early-life paracetamol (#Tylenol) exposure on behavior & monoamines in the rat central nervous system Exposure during critical periods may influence cognitive function & neurotransmission w/ differing males & females effects pubmed.ncbi.nlm.nih.gov/41587685/

@JillEscher , I so appreciate you. Perhaps we can serve as a model for how people can find common ground while still respectfully disagreeing. You and I are aligned on a number of important issues: the rising prevalence of autism, the significant support needs faced by those with profound autism, the importance of the prenatal environment, and the need for serious scientific inquiry. I’m also intrigued by your hypothesis regarding germline mutations, particularly as it relates to the growing recognition of the role of de novo mutations in autism. At the same time, we differ on a number of issues, including the potential importance of postnatal environmental exposures and illness, especially in relation to neurodevelopmental regression, co-occurring medical conditions, and overall severity. We also disagree about communication options for nonspeakers and the role of motor differences in that population, though I also want more research. At the end of the day, the autism community needs to focus on being on the SAME TEAM, and the relentless attacks by the same three or four people need to stop. We should focus on common ground and on the shared goal of helping children and families — not only our own children, but the many children and families struggling now and those still to come as prevalence continues to rise.

"etiologic risk-factors for ASD could extend over multiple generations through different underlying mechanisms, suggesting new directions for research on genetic and non-genetic risk-factors" pubmed.ncbi.nlm.nih.gov/42097524/ Including 'non-genetic risk factors' (for some autisms)

Neuroinflammatory Mechanisms and Pharmacological Advances in Autism Spectrum Disorder: From Inflammatory Pathways to Targeted Interventions frontiersin.org/journals/immun… "propose the Peripheral-to-Central Inflammatory Cascade-Amplification Model (PC-ICAM)"

@JMac43404031 56% acetaminophen exposure rate in Brandlistuen is consistent with rates reported worldwide utilizing biomarkers or maternal report. 7.5% utilization reported in Ahlqvist & 2% in Prahm are inconsistent w/ other studies in their respective countries during the same time periods.

@AnnBauerZ I’d say this one more accurately captures exposures but what do I know? 🤷‍♀️

1st sibling controlled analysis of prenatal #acetaminophen use & neurodevelopment found positive associations. Did this study differ from recent 1s in important ways? Only study w/ same-sex sib pairs, Self-reported use in # days, continuous outcomes? #dyt183-T1" target="_blank" rel="nofollow noopener">pmc.ncbi.nlm.nih.gov/articles/PMC38…

“ongoing research integrating mechanistic & epidemiological approaches is still essential to clarify developmental consequences of fetal paracetamol (#TYLENOL) exposure & to inform evidence-based recommendations for safe dosing regimens for maternal analgesic & antipyretic use.”

All of the full-time employees in the Centers for Disease Control and Prevention's Vessel Sanitation Program were fired by Robert Kennedy last April. What could go wrong? Now we know. cbsnews.com/news/cdc-cruis…

"Autism spectrum disorder occurred exclusively in this group and was consistently associated with temporal lobe white matter abnormalities" pubmed.ncbi.nlm.nih.gov/42092723/ Autism in the context of congenital CMV exposure. And some futher research and clinical clues...

"The consistency of cognitive profiles, scatter scores, and strengths and weaknesses was poor." link.springer.com/article/10.100… Long-Term Stability of IQ Scores for Children With Neurodevelopmental Disabilities.