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Happy to contribute along with many other colleagues to the 2 Kidney papers bridging @KPMProject and @_hubmap that are just out today in @Nature and @NatureComms :
nature.com/articles/s4158…
nature.com/articles/s4146…
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Tarek M. Ashkar (El-Achkar)
723 posts
Tarek M. Ashkar (El-Achkar)
@AshkarLab
Physician Scientist, Nephrologist. Interests: #AKI, #Uromodulin, Multiplex imaging & Spatial analytics, Immune mediated kidney injury. Investigator @KPMProject
Indiana, USA Katılım Mayıs 2017
497 Takip Edilen655 Takipçiler
Tarek M. Ashkar (El-Achkar) retweetledi
Kidney casts contain high levels of PROM1, a marker linked to cell damage and dedifferentiation based upon new #ASNCJASN study. kidney.pub/CJASN0982
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Registration link
iu.zoom.us/webinar/regist…
Preliminary agenda
nam12.safelinks.protection.outlook.com/?url=https%3A%…
Tarek M. Ashkar (El-Achkar)@AshkarLab
Save the Dates: May 20 & 21, 2026 The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!
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Save the Dates: May 20 & 21, 2026
The Indiana O’Brien Center for Advanced Renal Microscopy will host a virtual workshop on Spatial Protein Imaging. Details coming soon on the program and registration (free). Stay tuned!!
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@Carmendemigue12 @KidneyInCVD Thank you so much Carmen! So kind of you. Big kudos to all the team, but especially Azuma Nanamatsu who has been the driving force behind this work.
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What proteins do kidney tubular casts contain? More than what you think but with notable absences. New in CJASN journals.lww.com/cjasn/abstract…
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The secret of youth: posting a profile picture on the university website. Diamonds are forever.
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Tarek M. Ashkar (El-Achkar) retweetledi
‘‘Tis always the season for Uromodulin
NKF Nephrology Professionals@NKF_NephPros
❄️🎄 On the First Day of Continuing Education, NKF gave to me… a new episode exploring uromodulin. Dr. Gaddy. LaFavers, and Garimella explore uromodulin's role in infection defense, AKI, and kidney stress. bit.ly/3DamjQ9 @klafavers @pranavgarimella @AnnaGaddy
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Times have changed. Reviewing papers stopped being predominantly a duty and an academic privilege, to also becoming an integral part of a multi-billion dollar publishing industry. Compensate reviewers? Any other examples of industry sustained by free work?
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The Role of the Vascular Niche in Regulating Kidney Tubulo-Interstitial Fibrosis - Kidney International kidney-international.org/article/S0085-…
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This perspective in @asnpublications CJASN discusses the importance of spatial biology in studying kidney disease and the translational implications to identify therapeutic targets and biomarkers. journals.lww.com/cjasn/citation…
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Happy to contribute to this superb work!
ASN Publications@asnpublications
The lymphatic system has historically been understudied due to the difficulty of distinguishing it from the blood vasculature. This #ASNKidney360 paper's authors optimized an antibody-based method for imaging hard-to-visualize adult murine kidney lymphatics. Read more: kidney.pub/KID0919
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Linking histology with Omics. Happy to contribute to this work that offers a really nice tool. @_hubmap nature.com/articles/s4146…
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Kudos to all the team @IUKidney and all the collaborators and especially the participant heroes from @KPMProject who made this work possible
IU School of Medicine@IUMedSchool
Kidney diseases are a leading cause of death in the U.S. They affect 14% of adults, often without knowing it. IU researchers are mapping kidney cell types to improve diagnosis and open the door to more precise therapies. bit.ly/47HwKHE
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@ivivek87 Thanks! Yes, there were intermediary states THY1+, PROM1+(and VCAM1+), but loss of THY1 and persistence of PROM1 seems to correlate with injury and maladaptive repair.
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@AshkarLab Congratulations! PROM1 has always been a bit double edged sword. Really interesting to see this.
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Our latest in @ScienceAdvances from a large collaboration through @KPMProject . We characterize a population of PTs in human kidney that express the regenerative marker THY1. THY1+ PTs are lost in kidney disease science.org/doi/10.1126/sc…
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Tarek M. Ashkar (El-Achkar) retweetledi
Kidney cells can protect themselves during injury, but the mechanisms were unclear.
ASCI member Tarek M. El-Achkar @AshkarLab & team @IUMedSchool now show that oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production.
View paper: jci.org/articles/view/…
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Very nice excited to see this work published and also the super well done editorial by @Vishal_D_Patel
Journal of Clinical Investigation@jclinicalinvest
Kidney cells can protect themselves during injury, but the mechanisms were unclear. @AshkarLab & team @IUMedSchool now show oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production. View paper: jci.org/articles/view/…
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Looking forward to this tomorrow!
Leica Microsystems@LeicaMicro
How do trillions of cells work together to form & maintain the human body? @AshkarLab & @sarahteichmann1 will guide you through 3D & 4D spatial imaging, uncovering how organs function, develop, & respond to disease. Join the discussion! fcld.ly/hyh0vuq #CellMapCrew
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