Glen

Carl Jung was not playing around when he wrote: “No matter how isolated you are and how lonely you feel, if you do your work truly and conscientiously, unknown allies will come and seek you.”

Predictive coding describes a model - but that model is implemented through real neural circuits, where excitation and inhibition shape how strongly signals are processed and updated. Often framed as: precision (prediction weighting) ≈ neural gain ≈ E/I balance.

@KH118118 Agreed - I’m a big believer in systems thinking. Conditions overlap, systems interact. 🎯

“If it improves with treatment, it must explain everything” isn’t how medicine works. Conditions overlap. Systems interact. Comorbidity exists. Improvement doesn’t have to equal misdiagnosis. That’s just how biology works, and it goes far beyond #FND.

@TomPlender If excitation outweighs inhibition, the brain becomes more certain… and less flexible. Harder to update - and harder to shift.

@TomPlender As arousal increases (which changes how strongly the brain weights its predictions) ↑ noradrenaline ↑ glutamate ↓ GABA tone the system shifts toward excitation

If you're interested in modern theories of #FND functional neurological disorder- this looks like a great paper- emphasis on viewing FND through a predictive coding framework academic.oup.com/brain/advance-…

@purposeful_pd I’m not afraid of exercise, but my system can still react to it as a stressor - activating the same physiological response.

@purposeful_pd I think the article is moving toward a brain network model. I agree with your point about fear It’s interesting though - I think the word itself can put people off. It’s often taken as something conscious, which it can be, but the underlying threat response can also be automatic

Science is shedding new light on a disorder medicine once forgot. For a long time, conditions like FND were dismissed. That’s changing. This Harvard article explains why: magazine.hms.harvard.edu/articles/funct…

Put simply, the brain looks less “overworked” in nature. theconversation.com/what-happens-t…

@SarahLidstone @HaseelBhattPT @IntegratedMove @KITE_UHN @UHNSHSNeurology @FNDSociety Now, from the perspective of a Parkinson patient may I suggest something radical? Unfortunately, all the experts will never get in the same room. The reality of something like FND is so much messier. There’s nobody to treat the whole. We need a whole new profession in healthcare.

1/"The distinction between diseases of 'brain' and 'mind', between 'neurological' problems and 'psychological' or psychiatric ones is an unfortunate cultural inheritance the permeates society and medicine,

@purposeful_pd Yeah, me too - as a kid, I chewed on everything. Cuffs in particular were always chewed to bits. In autism it’s often linked to sensory processing + stimming - a way of regulating the system. #causes" target="_blank" rel="nofollow noopener">psychcentral.com/autism/oral-fi…

@AutonomicGC I was a nailbiter for many many years.

Looking back to primary school, before I understood anything about the nervous system, I was already trying to regulate it - chewing cuffs, collars, anything I could get hold of. I just didn’t know what I was doing. #ASD

Understanding the brain is key to advancing understanding of Functional Neurological Disorder. #BrainAwarenessWeek #BAW #FND #neurology #BrainHealth #MedEd

Temperature sensitivity is commonly reported in #MECFS and #fibromyalgia. Much of it points toward abnormalities in the autonomic #nervoussystem, which helps regulate temperature, circulation, and other core functions. #SystemsThinking verywellhealth.com/temperature-se…

This man literally tells Neuroscience trick to stop negative thought loops.

Sometimes the most powerful question we can ask ourselves isn’t “Why did this happen to me?” It’s “What can I do with this now?” …trust the process

Interesting research suggesting undigested fructose may contribute to #inflammation & #anxiety through the gut–brain axis. Another example of how diet, the #microbiome, immune signalling and the #nervoussystem are deeply interconnected. #SystemsThinking psypost.org/undigested-fru…

The absence of biomarkers does not invalidate the physiological reality of symptoms after #exertion. Many processes in the brain and #nervoussystem remain difficult to capture with current tests. Symptoms themselves are evidence that something physiological is happening.