Philip Brown

@kimreynolds_lab based @UTSWMedCenter show that biochemical coupling between metabolic enzymes shapes the range of enzyme activities sufficient to rescue cell growth nature.com/articles/s4146…

A long-acting #LEAP2 agonist as a new treatment for #MAFLD #fattyliver and #obesity ? @oceankripa and the rest of the @ZigmanLab say YES! #ghrelin authors.elsevier.com/sd/article/S22… preprint now available @MolMetab @UTSWMedCenter @UTSWInternalMed @UTSWBrain @UTSWdiabetes

Physical protein interactions constrain interface sequence. But what about non-binding "biochemical" interactions in metabolism? We used deep mutational scanning to map sequence constraints for two enzymes that catalyze consecutive metabolic reactions: rdcu.be/dE7xl

The “ORBIT for E. coli” paper is out in Nucleic Acids Research! doi.org/10.1093/nar/gk… **Perform genetics (e.g. deletions) without any PCR / cloning – just transform an oligo!** The paper demonstrates benefits over λ Red & shows how oligos scale to high throughput libraries.

@E_L_Isenstein @JohnnyFoxe CONGRATS!!!

I am overjoyed to share that I defended my dissertation on Monday!!! Many thanks to my PIs @JohnnyFoxe, Duje, and Ed for all of their support, and to everyone who has helped me along the way! Next stop: back to medical school to wrap up the MD/PhD! 🩺

Our @NIDDKgov lab is seeking a #postdoc for exciting project assessing how human #liver in #MASLD handles fasted-to-fed transition. Unicorns comfortable with bioinformatics, molecular biology and physiology should apply. Details 👇 Friends please RT! niddk.nih.gov/research-fundi…

Proud to share our recently published work from @kimreynolds_lab! Ever wanted to quantify epistatic relationships between genes? Here’s our proposed model in E. Coli! A continuous epistasis model: Cell Systems cell.com/cell-systems/f… #UTSW #genetics #systemsbiology #mstp

Goood (late) morning! This is Phil Brown (@B3Phil) here - long time metabolism fan, and current student in the Molecular Metabolism & Metabolic Disease Track! I’m at the controls of the UTSW3MD Twitter (X?) account today - so I’ll share about myself and a day in the life of 3MD!

Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism dlvr.it/T0ySTw

Our 1st preprint! We developed a genetic toolkit for E. coli that directly uses cheap DNA oligos to specify kb scale mutations. No PCR/cloning to delete genes! The paper demonstrates benefits over λ Red & gets fancy w/ pooled mutant libraries. 1/15 biorxiv.org/content/10.110…

I always carb load before bioinformatics.

Congratulations to @ginajpark on receiving the 2023 Ida M. Green Award! In her dissertation research, Gina discovered the mechanism of mRNA capping by SARS-CoV-2, involving a novel reaction catalyzed by a pseudokinase domain. Congratulations, Gina!

We are so proud of @VancityReynolds ...well not that Ryan Reynolds, but our Ryan Reynolds on his PhD thesis defense today.

#MetabolismMasterclass today at 4PM Today's speaker is Dr. Joachim Herz. "Preventing Alzheimer’s – Novel Mechanisms and Therapeutic Approaches" @UTSWGradSchool @UTSWmstp @UTSW_NeuroGrads @UTSWNeurosci @UTSWNeurology

An underrated powerhouse, the #liver aids with detoxification and digestion, but its ability to store fat can contribute to #FattyLiverDisease. Read about how @NIDDKgov #NIH_IRP Senior Investigator Yaron Rotman @NASH_and_coffee is studying this: bit.ly/3ZEmgBI

#Metabolize with us on Thu 3/9 5pm at "Bottles & BS". Organized by @UTSW3MD's Social Committee. Faculty Guest Dr. Markey McNutt. Food is on us! @UTSW3MD @UTSWGradSchool @GDDgradprogUTSW @UTSWmstp @UTSW_NeuroGrads @UTSWCancerBio students are invited.

@UTSWGradSchool @GDDgradprogUTSW @UTSWmstp @UTSW_NeuroGrads @UTSWCancerBio @CmbUtsw students this is for you. "Bottles & BS". Brought to you Thursday 2/16 6pm. Hosted by @UTSW3MD's Social Committee with @B3Phil. See you there!! #metabolize with us at @on_rotation. Food is on us.

Group Photo!!! #GDDRetreat2023

Cornell is increasing grad stipends to $43k for next year, requiring summer funding to be provided for all PhD students, cutting grad tuition costs for private Cornell colleges cause they are currently higher than the public ones

I recently learned that my tenure application was approved!! So grateful to all the fantastic students, fellows, and staff that I've had the privilege of working with. What a great lab team. And excited for what comes next! @MolBiophysUTSW @LHBioinf_UTSW @UTSWcomps