Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉

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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉

Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉

@BLLPHD

Professor @Pennmedicine We create #CellTherapy #Genetherapy - @TmunityTx & @CapstanTx CoFounder, Past President @ISCTGlobal, @PNASNexus AE

Philadelphia, PA Katılım Kasım 2010
473 Takip Edilen9.6K Takipçiler
Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉
Heading to the @ISCTglobal Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts. We’ve built an integrated platform designed to move programs from discovery into first-in-human studies with rigor, speed, and quality. What differentiates this model is not a single capability, but the integration: • cGMP Phase I manufacturing in 15 ISO 7 suites • Process development and scale-up for complex cell therapies • End-to-end QC analytics and FACT-aligned quality systems • Advanced correlative science, including multiparameter flow, molecular assays, and spatial biology • Deep experience translating across oncology and immune diseases We are actively looking to partner with biotech, pharma, and academic groups in three areas: • Manufacturing: early-phase and first-in-human CGT production • Process development: improving robustness, scalability, and comparability • Analytics and correlative studies: biomarker strategies that inform mechanism, response, and durability If you are advancing a program and need a partner who understands both the science and the realities of clinical translation, we should connect to build the next generation of cell and gene therapy together. #celltherapy #genetherapy #innovation #immunotherapy
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
Paul Knoepfler
Paul Knoepfler@pknoepfler·
My new @statnews.com column. Did Kennedy just stack the deck on FDA oversight of peptides? It sure looks like it statnews.com/2026/04/29/rfk… Don't expect new PCAC to be independent/ focused on trial data. It's also really RFK Jr. in control of some key decisions at FDA. What's next?
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉
The case for heritable human genome editing (HHGE) assumes unmet medical need, but current data argue otherwise. Preimplantation genetic testing (PGT-M) already enables most at-risk couples to avoid transmitting monogenic disease with high success rates (Treff et al., Fertil Steril 2019; Girardi et al., Hum Reprod Update 2020). In parallel, somatic gene editing is now clinical reality, including CRISPR therapies for hemoglobinopathies and in vivo editing for ATTR (Frangoul et al., NEJM 2021; Gillmore et al., NEJM 2021). When effective, non-heritable options exist, the rationale for HHGE becomes minimal. Even proposed future indications for HHGE do not withstand scrutiny. True edge cases with no viable unaffected embryos are exceptionally rare, and emerging reproductive technologies may further reduce them (NASEM 2017, 2020). For common diseases, polygenic risk is not a tractable editing target due to small effect sizes and population variability (Torkamani et al., Nat Rev Genet 2018; Mostafavi et al., eLife 2020). The trajectory of innovation is moving toward somatic, not heritable intervention.
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉
The safety barrier to HHGE is not incremental risk but fundamental uncertainty. Embryo editing still produces unintended outcomes, including off-target edits, large deletions, and chromosomal alterations. (Kosicki et al., Nat Biotechnol 2018; Zuccaro et al., PNAS 2020). Mosaicism remains common, meaning edited embryos contain mixed cell populations with unpredictable biology (Liang et al., Protein Cell 2015; Egli et al., Nature 2018). Each unintended outcome affects many cells, potentially entire lineages. These are intrinsic limitations of current technology, not rare exceptions. Risks extend beyond sequence changes to development and inheritance. DNA repair in embryos is poorly controlled (Ihry et al., Nat Med 2018), epigenetic programming may be disrupted (Greenberg & Bourc’his, Nat Rev Mol Cell Biol 2019), and any adverse effect could propagate across generations. There is no feasible way to establish multigenerational safety before clinical use (WHO 2021; NASEM 2020). Even considering non human primate models, 3-4 generations (15-20 years) would be needed. By that time improvements in pre-implantation genetic diagnosis and somatic cell gene editing makes the use case much much smaller than now. Not a business model for smart investing. Experience to date reinforces this: even simple targets produce complex outcomes (Cyranoski, Nature 2019; Wei & Nielsen, Cell 2019). HHGE does not meet a threshold for clinical readiness
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉
Current technology is in no way sufficient to ensure the safety of human heritable genome editing (HHGE) of embryos, eggs, sperm. HHGE provokes fundamental questions related to the nature of the human person and the future of humanity. Companies acting without transparency, regulatory oversight or societal consensus, should not decide the timing and conditions for any potential HHGE application. #ethics #bioethics #genetherapy #geneediting
Emily Mullin@emilylmullin

Two companies that launched last year with plans to make gene-edited babies have already shut down. Bootstrap Bio's CEO told WIRED: "We ran out of money... I couldn’t get enough investors interested for us to keep our operation going." wired.com/story/designer…

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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉
Answers why so much advertising & govt allowance of sports, other betting
Aakash Gupta@aakashgupta

Warren Buffett, in his first sit-down since stepping down as Berkshire CEO, gave the cleanest indictment of legalized gambling in a decade. He called it a tax cut for the wealthy. The math proves him exactly right. Americans wagered $165 billion at legal sportsbooks in 2025. They lost $16 billion of that. FanDuel pulled $6 billion of the losses. DraftKings pulled $5.3 billion. Every state with legal mobile sports betting collected a tax on the bettor side. New York alone took in over $1.2 billion in 2025 sports betting tax revenue. Layer the lottery on top. State lotteries generate over $90 billion a year. The bottom half of income earners account for roughly 70% of total spend. The average lottery player makes $38,000. A household earning $20,000 spends three times more on tickets than one earning $30,000. The implicit tax rate, meaning whatever the state keeps after prizes, runs 30 to 50% depending on the game. No other revenue source in America has that base and that rate. The structural design is the engine. A single straight sports bet carries a hold of 4 to 5%. A four-leg parlay carries a hold above 30%. FanDuel and DraftKings spent five years rebuilding their apps to make parlays the default product. FanDuel's blended hold rate hit 11.4% in 2025, up from roughly 7% in 2022. The product got worse for the customer and the customer wagered more anyway. Now look at the substitution. Nine US states have no state income tax. Seven of those nine run state lotteries. Seven of those nine have legalized sports betting. The states most committed to never taxing wealth are the same states running the largest extraction machines on people who cannot afford to lose. Read it as policy. Here is what Buffett is actually pointing at. The state needs revenue. It can raise income tax on the top decile, or it can run a lottery plus a sports betting tax. The second option raises the money from the people who can least afford it. The first option becomes politically optional. New York's $1.2 billion in 2025 sports betting tax is $1.2 billion the state did not have to ask of someone earning $5 million. DraftKings and FanDuel sell a privatized collection mechanism for a regressive tax that the state never has to defend at the ballot box again. Voters approve legalization once. Collection runs forever. The state takes a cut. The wealthy get a quieter top bracket. The bettor's cut shrinks every quarter as the parlay menu gets pushed harder. The function of a government, Buffett said, is not to play its people for suckers. Thirty-nine state governments now do.

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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
Derek (Del) Pickard
Derek (Del) Pickard@DelPickard·
A moving Guest Essay by Rebecca Archer in Wednesday's NY times details the loss of her daughter, Renae, who contracted the virus before she was old enough to be vaccinated. The vital importance of herd immunity to protect vulnerable infants must not be forgotten. At the time there was a measles outbreak where Rebecca lived in the UK..
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
Breakthrough
Breakthrough@brkthroughprize·
The man who climbed Taipei 101, @AlexHonnold, and Academy Award winner Anne Hathaway highlight the spirit of curiosity that drives scientific discovery. Reflecting on breakthroughs in gene editing, they honored the researchers and physicians behind life-changing therapies, including Kiran Musunuru, Rebecca Ahrens-Nicklas, Peter Marks, and 2025 Breakthrough Prize in Life Sciences laureate David Liu—whose work led to the treatment for baby KJ, also present at the event. Watch the 2026 Breakthrough Prize Ceremony premiere on Sunday, April 26 at 3 PM streaming on this platform.
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
LenaSun
LenaSun@bylenasun·
NEW: After I reported that CDC won’t publish a report showing covid vaccine cut ER visits and hospitalizations among healthy adults by about half this past winter, @SenBlumenthal is asking the head of CDC for records and information about the decision. 1/3
LenaSun tweet mediaLenaSun tweet media
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
The Washington Post
The Washington Post@washingtonpost·
A report showing the efficacy of the covid-19 vaccine that was previously delayed by the head of the CDC has been blocked from being published in the agency’s flagship scientific journal, according to people familiar with the decision. wapo.st/3QCMmps
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
LenaSun
LenaSun@bylenasun·
SCOOP: A report showing the effectiveness of the covid-19 vaccine that was previously delayed by the head of the CDC has now been blocked from being published in the agency’s flagship scientific journal, per sources. My latest. washingtonpost.com/health/2026/04…
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Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 retweetledi
ProPublica
ProPublica@propublica·
WATCH: Researchers at Stanford University modeled how many people could die or be disabled in 25 years if vaccines for polio, measles, rubella or diphtheria were no longer available. We illustrated their findings. Read more: propub.li/4cBGdRE
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