Todd Webb

New open-access Translational Psychiatry paper: multi-omic integration + drug repurposing to identify FDA-approved treatments for opioid use disorder. Led by POP-GEM’s @BToddWebb. Approach generalizable across complex traits & disorders. nature.com/articles/s4139… #OUD

🚨 Update! The preprint for our study using ML to predict alcohol consumption via biomarkers in the UK Biobank is here! 🎉 Led by @MufalhHassan w/ @AmandaEGentry @PetersonRoseann @BToddWebb. 🔗[medrxiv.org/content/10.110…] #MachineLearning #AIinGenetics #OpenScience

🚨 Just submitted! Led by @MufalhHassan, we used ML to predict alcohol consumption via biomarkers in the UK Biobank. 🔑 Key points: ✅ ML > Traditional methods ✅ Biomarkers improve accuracy ✅ Explainable AI reveals risks Stay tuned! @AmandaEGentry @PetersonRoseann @BToddWebb

5/5, Catch @CChatzinakos at #ASHG2024! 🧬 "Approximating Polygenic Risk Score Effects Using Summary GWAS Data." 📊 Explore innovative PRS methods advancing large-scale genetic studies! Join us on Nov 7, 3-4:30 PM MT. 🌍 #Genetics #PRS @sunydownstate @thebigdeli @PetersonRoseann

4/4, Check out @thebigdeli at #ASHG2024! 🧬 "Multi-omics profiling of CAD highlights genetic regulation of the human plasma proteome." Dive into proteomics + GWAS insights! 🗓️ 11/7, 2:30-4:30 PM MT. #Genetics @PetersonRoseann @CChatzinakos @sunydownstate

3/3, Don’t miss @MufalhHassan at #ASHG2024! "Genetic Correlations Inform ML-Based Identification of Heavy Alcohol Consumption Using Biomarkers." 🤖 Discover how ML boosts prediction and screening! 🗓️ 11/7, 2:30-4:30 PM MT. #Genetics #ML @BToddWebb @AmandaEGentry @PetersonRoseann

2/2, Join @BToddWebb at #ASHG2024 for Poster Board 5078T! 🧬 'Genetic architecture & phenotypic assessment of alcohol use disorder in All of Us.' 📊 When? 11/7, 2:30-4:30 PM (Mountain). #Genetics @AmandaEGentry @PetersonRoseann @MufalhHassan

1/1,The POP-GEM Lab is heading to #ASHG2024 in Denver (Nov 5-9)! Don’t miss out on the groundbreaking work our team will be presenting. Come check out our posters showcasing advancements in genetic research. #ASHG24 #GeneticsResearch @sunydownstate @RTI_Intl @VCU_VIPBG 👇

Don’t miss out! 🧬 Team member Tan-Hoang Nguyen will be presenting on rare variant analysis for PTSD using whole-exome sequencing data! 🧪Join us on 11/08 for insights into #Genomics and #PTSDResearch at #ASHG2024!

A statement on the need for scientific rigor in the development of genetic tests, endorsed by @ISPGnet and signed by 140 experts in the field: Concerns about genetic risk testing for opioid use disorder - The Lancet Psychiatry thelancet.com/journals/lanps…

6/6📊 @thebigdeli presenting our findings on transdiagnostic factor analyses of psychosis symptoms and measurement noninvariance across clinical phases of illness.🗓️ 10/16 | 🕟 4:30 - 6:00 PM 🧠📊 #PsychosisResearch #WCPG2024 #MentalHealth

5/5🔬Peter Barr, @pbb2 will be presenting a multivariate genomic investigation of the externalizing spectrum and suicide risk at #WCPG2024. Don’t miss it!🗓️ October 16th | 🕟 4:30 - 6:00 PM #Genomics #SuicidePrevention #PsychiatryResearch

4/4🚀 Don’t miss @AmandaEGentry's poster on how MAGIC-XGBoost enhances unmeasured phenotype prediction and genomic discoveries of MDD in the UK Biobank!🗓️ 10/16 | 🕟 4:30 - 6:00 PM #Genomics #PsychiatryResearch #WCPG2024

3/3💡 @Madhur_B_Singh also sharing research on MDD from cross-ancestry genome-wide analyses in the UK Biobank! Discover enhanced genomic insights into major depressive disorder. 🗓️ 10/16 | 🕐 1:15 - 1:30 PM 🧠 #Psychiatry #GeneticsResearch

2/2 First up, POP-GEM Lab Director @petersonroseann presenting our work on the Trans-Ancestry GWAS Pipeline, empowering genomic discovery in large-scale EHR-linked biobanks! Learn more about MDD insights from the PsycheMERGE Diversity Initiative. 🗓️ 10/16 | 🕐 1:00 - 1:15 PM 🧬

1/1 Excited to kick off #WCPG2024 in Singapore! The POP-GEM Team will be presenting our latest findings on genetic and environmental influences on mental health. Stay tuned for updates! 🧬🧵👇

PSA, since I've now seen problems arising from this: As of Sept 2023, GATK no longer makes missing genotypes explicit in VCFs (i.e. "./." as in the VCF spec). Missing genotypes are instead coded as "0/0" with a DP=0 format field. See attached for examples.

Happy to share two new preprints from our group at @RTI_Intl and collaborators covering DNA methylation and gene expression differences associated with alcohol use disorder in human brain. medrxiv.org/content/10.110… medrxiv.org/content/10.110…

Here's a new preprint from our group. "Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases." medrxiv.org/content/10.110… @carynwillis94 @bryancquach @RTI_Intl