basebybase

Episode 367: How ancestral alternative splicing powered rapid jaw and trophic diversification in African cichlids — listen to the PaperCast episode to hear key findings and implications basebybase.com/episodes/ances…

New PaperCast episode: BRCA1P1, a BRCA1-derived pseudogene, suppresses antiviral responses in cancer—targeting it boosts ISGs, apoptosis and immune infiltration. Listen: basebybase.com/episodes/brca1…

New PaperCast Base by Base: CRISPR base-editor screens map MEN1 mutations that drive shared and drug-specific resistance to five clinical menin inhibitors, with structural and in vivo validation. Listen: basebybase.com/episodes/paper…

Episode 110: New exome-sequencing meta-analysis implicates STAG1, ZNF136 and six more genes in schizophrenia risk — hear the findings and implications basebybase.com/episodes/whole…

New PaperCast: Peripheral C4 in schizophrenia — neutrophil C4 protein links C4A gene copy number to immune activation and symptoms. Listen to episode 364 basebybase.com/episodes/perip…

New PaperCast episode: cfDNA size deconvolution exposes a 159 bp nucleosomal pivot and an entropy-based ctDNA signature that improves cancer detection. Listen now: basebybase.com/episodes/cfdna…

Academic Researchers right now:

New PaperCast episode: D614G rewires SARS-CoV-2 spike allostery to speed RBD opening and affect antibody access. Hear simulation and HDXMS evidence that explain variant fitness. Listen: basebybase.com/episodes/d614g…

New PaperCast: Biallelic CHCHD4 variants cause combined OXPHOS defects and severe early-onset mitochondrial disease; wild-type CHCHD4 restores complexes I and IV. Hear the study breakdown: basebybase.com/episodes/biall… basebybase.com/episodes/biall…

Terminal Genome Viewer github.com/zeqianli/tgv Another one that is around for a while: ASCIIGenome github.com/dariober/ASCII…

Most genomic AI models use fixed rules to process DNA into chunks, imposing arbitrary boundaries on a sequence with its own biological structure. @arnavshah0, @victor_ljz, and team developed dnaHNet, a tokenizer-free foundation model that learns its own segmentation from scratch, supervised by @_albertgu, @genophoria, and @BoWang87.

Check out this song! suno.com/s/S8Nl3tR5GcFp…

🧬 New from Adhikari et al! 📄 Bayesian Mendelian Randomization methods for Index Trait Bias correction in subsequent trait genome-wide association studies 👉 bit.ly/40FTUcW

🎧 New PaperCast: MVP + UK Biobank + FinnGen + MR with eQTL/pQTLs identify 69,669 causal gene-trait links and prioritize targets (AUC PR 0.79), including ANXA2 for lipids basebybase.com/episodes/bioba… @HGGAdvances

🎧 Episode 300: Population-scale WGS from UK Biobank and All of Us finds HLA/MHC class II antigen presentation predicts persistent EBV DNA and links to disease — listen basebybase.com/episodes/ebv-m… @NaturePortfolio

🎧 New PaperCast: Encephalopathy-linked UFM1 variants impair neuronal translation and synapse development, while Trazodone rescues translation in UFM1-R81C neurons @EmboMolMed basebybase.com/episodes/ufm1-…

🎧 New episode: Bi-allelic FSD1L variants linked to retinitis pigmentosa—exon 10b mis-splicing and axoneme localization suggest trafficking defects; Listen now @AJHGNews basebybase.com/episodes/fsd1l…

🎧 New PaperCast episode: Bi-allelic FSD1L variants disrupt a microtubule-associated protein causing hydrocephalus and callosal defects; mouse and iPSC studies show impaired ciliogenesis and neur… @ajhgnews basebybase.com/episodes/fsd1l…

🎧 snaR-A binds U2 snRNP subunit SF3B2, driving intron retention and proliferation in human cells — we unpack the splicing mechanism and cancer links basebybase.com/episodes/snar-… @natureportfolio