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This time we went “functional.” 🙂
After years studying pathological amyloids, we followed RIPK1/3 into the other side of aggregation - where amyloids help cells decide when to die.
🔗🔗
biorxiv.org/content/10.648…
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Benedetta Bolognesi
1.1K posts
Benedetta Bolognesi
@Bennibolo
Biologist, Explorer. Group Leader @IBECBarcelona. Protein Phase Transitions.
Barcelona, Spain Katılım Aralık 2011
1.3K Takip Edilen1.1K Takipçiler
Big BIG congrats to @mbadiagraset . She led this work beautifully - thoughtful, rigorous, and relentless💪 .
There’s more coming from her! Stay tuned.
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Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.
IBEC@IBECBarcelona
🔬 Investigadores de l'#IBEC creen un mapa mutacional de l’amilina que mostra com certes mutacions poden accelerar o frenar la formació d’agregats tòxics vinculats a la diabetis tipus 2. 📖 ibecbarcelona.eu/an-unprecedent…
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We hope this is a small step forward towards understanding how aggregation can be tuned to fulfil different functions rather than disease!
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By coupling this with functional assays, we discover that necroptotic signaling requires a “sweet spot”🍭 of amyloid formation. Variants that disrupt this balance are rare in the human population, consistent with evolutionary sequence optimization.
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This time we went “functional.” 🙂
After years studying pathological amyloids, we followed RIPK1/3 into the other side of aggregation - where amyloids help cells decide when to die.
🔗🔗
biorxiv.org/content/10.648…
English
We find that both proteins rely on an evolutionarily conserved aliphatic tetrad to nucleate amyloids, but the prioritization of aliphatic interfaces differs: RIPK1 relies primarily on one interface, whereas RIPK3 engages two.
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@mamartin_ok mutagenised mouse and human RIPK1 & RIPK3, the proteins that assemble into amyloid structures to build the necrosome and signal inflammatory cell death 💀
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Benedetta Bolognesi retweetledi
Genomics job opportunities in Sweden! Our infrastructure has an open position for a postdoc with a focus on long-read sequencing, and a permanent (!) bioinformatician position in ancient DNA. Cutting-edge tech, great environment, work-life balance, nice country. Please RT!
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Our lab @IBECBarcelona is hiring both 👩💻 and 🧪 profiles (or mixed!) to mechanistically probe disordered and aggregation prone proteins at scale using combinatorial strategies. Get in touch!!
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New cocktail 🍹 in town - in collaboration with @BenLehner : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread by co-first author @immunobananna
Anna Arutyunyan@immunobananna
Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 science.org/doi/10.1126/sc…
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Benedetta Bolognesi retweetledi
La situació que vivim a Catalunya amb Rodalies és insostenible.
Més enllà de les inversions que s'estan fent actualment, necessitem trobar solucions immediates a un problema que li roba el temps i la vida als catalans i les catalanes.
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every academic you meet is fighting their own battle. Make it worse by asking them how the writing is going
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Very grateful to @FundacionLuzon & @CaixaResearch @FundlaCaixa for their support in this journey which I hope will bring my lab @IBECBarcelona , @LukeMcAlary & Bryony Thompson to make important contributions towards a systematic understanding of #ALS #ELA #MND
Fundación Luzón@FundacionLuzon
🔬 Ayer estuvimos en @CaixaForum Madrid entregando nuestra beca #TalentoELA al proyecto ganador de este año para investigar sobre la ELA. 🤝 Este proyecto de investigación será financiado durante tres años por @FundlaCaixa y por nuestra fundación. 👏🏼 ¡ENHORABUENA!
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Benedetta Bolognesi retweetledi
HPV vaccines offer a rare opportunity to effectively eliminate cervical cancer.
By taking this opportunity, it’s possible to save the lives of hundreds of thousands of women each year.
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Benedetta Bolognesi retweetledi
More than a million views! This emotionally honest performance by @_CaitlinORyan getting this recognition is so well deserved. 🫶Thanks to #spitnights for letting everyone know what I've always known - how incredibly intelligent and talented Caitlin is. 🙌
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