Bigas/Espinosa Lab

The 7th NF-kB International Congress is here! 📅 October 7–9, 2026 📍 Barcelona Biomedical Research Park (PRBB) Join leading experts to explore the latest advances in signaling, inflammation, and disease. 🔗 Register now and don’t miss it! #NFKB #BiomedicalResearch #Barcelona

🔬Researchers from @HMar_research & @hmarpath have identified a key mechanism behind colon cancer metastasis. 🧬A lack of the IKKα protein enables tumour cells to cluster together & survive during dissemination. 📊@NatureComms. 🗞️More: researchmar.net/news/806/ @hospitaldelmar

📣Happy to start the year by sharing our team’s latest work on the development of dormant hematopoietic stem cells (HSCs), now available on bioRxiv: biorxiv.org/content/10.648… We show that a population of dormant HSCs with high regenerative capacity is established in the embryo.

Happy to share our minimal fetal-like gene signatures (ColoStem & EpiColoStem) that identify high-risk colorectal tumors in >1,100 patients and are measurable by qPCR in tissue and plasma, enabling patient stratification for future targeted therapies. #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4141…

Desxifren els esdeveniments genètics que desencadenarien una leucèmia en pacients d’un trastorn rar: la deficiència en GATA2🧬 L’estudi s’ha fet gràcies a models avançats del trastorn fets pels investigadors, una eina clau en la recerca d'ara endavant 👉 idibell.cat/2025/11/desxif…

La Dra. Anna Bigas, investigadora @HMar_research i @CarrerasIJC, s'incorpora com a #editoraassociada a @Dev_journal📰 Està centrada en el camp de la biologia del desenvolupament i malalties associades a processos embrionaris @Co_Biologists @BigSpinLab hospitaldelmar.cat/ca/noticies/vi…

We are delighted to welcome Anna Bigas (@BigSpinLab) from Hospital del Mar Research Institute and Josep Carreras Leukemia Research Institute as a new Associate Editor at Development, handling papers on #haematopoiesis, #signalling and #cancer. #anna" target="_blank" rel="nofollow noopener">journals.biologists.com/dev/pages/edit…

Check out this new research from the @BigSpinLab! The authors found that IκBα accumulates specifically in the chromatin fraction of mPSCs. 📚 More in @eLife: bit.ly/3Wt1Lsl

🩸Desarrollan modelos de embrión en laboratorio que producen células sanguíneas 🗨️Anna Bigas @BigSpinLab: "Es un trabajo muy preliminar que sugiere que, con las condiciones adecuadas, seremos capaces de obtener muchos tipos celulares" sciencemediacentre.es/desarrollan-mo…

It's always a pleasure to work together!🔬👩‍🔬

New paper from our lab finally online 🔥. Congrats to the amazing first author 👏🏽 @Fra_Matteini💥, wonderful collaborators Anna Bigas @BigSpinLab and Antonio Del Sol @delSolLab Stem Cell Aging Team @idibell_cat 👇🏽👇🏽👇🏽 Notch in HSC aging doi.org/10.1182/blood.…

📢New Workshop on NF-kB: Cell Plasticity and Cancer 📅 Tues 23 Sep ⏰ 9.30 h 📍 Charles Darwin Room The workshop will feature presentations from a range of distinguished experts in oncology research ℹ️ researchmar.net/agenda/977/wor…

Thrilled to share with you the latest work from my PhD in @BigSpinLab @HMar_research @CarrerasIJC published in @BloodPortfolio We’ve programmed blood stem cells from PSCs using CRISPRa screen and found a new “bloody” cocktail #CRISPR #HSCs #StemCells kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

🚨New paper out!🚨 🔬 CRISPRa screening during mesodermal differentiation identifies 7 key genes with HSC induction potential. 🧬 A 7-gene cocktail drives multilineage repopulation and self-renewal from mouse ESCs. 📄 Don’t miss it! doi.org/10.1182/blood.…

🔬 Join us for the next @hmar_research-@UPFbiomed Seminar! 🗓️15/07 📌Charles Darwin Room Talks by @bigas_anna @BigSpinLab & @AMartinezArias @icreacommunity 👉researchmar.net/agenda_en/911

🚀 New paper out! 🔬Discover how IκBα exerts distinct chromatin- and NF-κB-related regulatory functions, and how its chromatin-related activity restores intestinal stem cell function & differentiation 👉cell.com/cell-reports/f…

💬 "Som més a prop del somni científic de crear sang artificial amb finalitats terapèutiques"🩸 🔬📺 La recerca del @BigSpinLab, a les notícies de @som3cat ➡️ 3cat.cat/324/som-mes-a-…

A step closer to the confident production of #bloodstemcells for regenerative medicine Study published in @BloodJournal, from @BigSpinLab, @HMar_research and @CarrerasIJC @ASH_hematology @Menendez_Lab @clarabueno_74 @CienciaGob @recercauniscat researchmar.net/news/723/a-ste…

Happy to share that our work ‘An unbiased genomewide screen uncovers 7 genes that drive hematopoietic stem cell fate from mouse embryonic stem cells’ as first edition in @BloodJournal. Thank you to all collaborators for making this work possible! ashpublications.org/blood/article-…