BioPrime retweetledi
Just completed a drug discovery screening on @BioPrimeAI! Target: CDK4/6 - Breast Cancer | Best binding energy: -13.46 kcal/mol | Advancing science with decentralized compute. bioprime.one/results/JOB-0f…
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BioPrime
32 posts
BioPrime
@BioPrimeAI
10,000x faster drug discovery $5 vs $50,000+ for molecular docking Production platform running 24/7 Melanoma • Diabetes • HIV https://t.co/5MSALekFy5 🧬
Katılım Ocak 2026
36 Takip Edilen44 Takipçiler
BioPrime retweetledi
@BWDaugherty @BioPrimeAI **Seeing such strong binding energy begets hope for impactful treatments.** w/
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We are proud to announce TopoGrammar, a platform designed to illuminate the "dark matter" of the genome. While traditional pipelines focus on dosage, #TopoGrammar focuses on topology.
Bryan Daugherty@BWDaugherty
Introducing TopoGrammar: Cracking the "VUS" Code with 3D Genomics & Blockchain 68% of identified ##genomic variants are currently classified as "Variants of Uncertain Significance" (#VUS). For patients, this means a #diagnostic dead end. The Problem: Conventional sequencing misses "balanced" structural variants, inversions and translocations that don't change gene dosage but do wreck the genome's 3D regulatory architecture. The Solution: #TopoGrammar treats chromatin organization as a structured language. By modeling enhancers and promoters as "grammatical sentences," we identify disruptions that others miss. The Tech:🧬 PINNs: Physics-informed neural networks for high-fidelity 3D reconstruction. 🎯 - CTCF-Gating: 91% boundary detection accuracy (outperforming HiCCUPS). ⛓️ #Blockchain - Attestation: Every result is hashed to the #BSV blockchain for immutable, @US_FDA-compliant verification without exposing PHI. The Results:• 68% VUS reclassification rate. • 93% pathogenic accuracy. • Seamless integration with @BioPrimeAI v4.0 for genome-to-drug workflows. Stop guessing on VUS. Start decoding the #3Dgenome. 🔗 Try the Live Demo: huggingface.co/spaces/GotThat… @SmartLedgerTech @bioprimeai @Sdot2121 @Codenlighten1 @jalexanderm @grok #Genomics #PrecisionMedicine #AI #Biotech
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@RIPVaulted @jalexanderm Thank you! 💗 This is citizen science in action. Welcome to the future of DeSCI
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This is amazing ❤️ and needs more awareness! From women across the globe, let me say, thank you @jalexanderm and @BioPrimeAI!
What an amazing opportunity!
BioPrime@BioPrimeAI
"Finding cures shouldn't be locked behind pharma boardrooms." @jalexandermartin just became our sole Breast Cancer Research sponsor - and he's giving $5 to every new citizen scientist who joins. 1 million compounds. Free. 🎀 bioprime.one
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BioPrime retweetledi
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The best #technology in the world means nothing if people don't believe it can change their lives. @jalexanderm makes people believe. And belief? That's what turns platforms into movements.
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All verifiable on blockchain for auditability, transparency, and integrity. Go @SmartLedgerTech team!
BioPrime@BioPrimeAI
BioPrime's sponsor community is making history. @jalexanderm leading breast #cancer #research. @SmartLedgerTech, @OriginNeuralAI, @BWDaugherty, @Codenlighten1 & @Sdot2121 backing 10 disease targets from #Alzheimer's to #tuberculosis. 6.3M compounds screened. DeSCI ♥️
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BioPrime's sponsor community is making history. @jalexanderm leading breast #cancer #research. @SmartLedgerTech, @OriginNeuralAI, @BWDaugherty, @Codenlighten1 & @Sdot2121 backing 10 disease targets from #Alzheimer's to #tuberculosis. 6.3M compounds screened. DeSCI ♥️
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BioPrime live stats: 6.3M compounds screened, 18 jobs completed, 28 users, 62.9s avg completion time. Every job coordinated on BSV—micropayments, result verification, data provenance, fractionalization. This is what production infrastructure looks like in drug discovery. 🧬⛓️
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Drug discovery demands immutable #data provenance.
BioPrime uses #BSV (@SmartLedgerTech) to timestamp every docking result, ensuring #research integrity from compound screening to publication.
When lives depend on your data, you don't compromise on #blockchain capacity.
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"Finding cures shouldn't be locked behind pharma
boardrooms."
@jalexandermartin just became our sole Breast
Cancer Research sponsor - and he's giving $5 to
every new citizen scientist who joins.
1 million compounds. Free.
🎀 bioprime.one
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BioPrime retweetledi
@GlucoseNot @BWDaugherty Metabolic targeting is why BioPrime screens multiple cancer pathways.
Active campaigns:
• Melanoma (BRAF V600E)
• Breast cancer (CDK4/6)
• HIV-1 Protease
Targeting metabolism requires compounds that work. Molecular docking accelerates discovery.
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@BWDaugherty @BioPrimeAI Dr. Otto Warburg proved that cancer cannot live in an alkaline environment!!
Dr. Thomas Seyfried proved that there are many causes of cancer, bacterial, viral, genetic etc... but ALL cancer cells at the earliest point in their existence ferments rather than respirates oxygen!!
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Just completed a drug discovery screening on @BioPrimeAI! Target: CDK4/6 - Breast Cancer | Best binding energy: -5.32 kcal/mol | Advancing science with decentralized compute. bioprime.one/results/JOB-c5…
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@cryptotweek1 Exactly right. Every BioPrime docking result → BSV blockchain → immutable proof.
No lab notebooks. No trusted intermediaries. Just cryptographic hashes + timestamps.
Blockchain as public notary for computational science.
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🚨BREAKING 🔥 🔥🔥
@BioPrimeAI has timestamped a CDK4/6 drug-discovery result using a public, cryptographically verifiable ledger.
Rather than publishing proprietary molecular data, the team committed cryptographic hashes of the exact protein structure, predicted binding pose, and model output, along with a digital signature, to an immutable public record. This creates an independently verifiable proof that a specific computational result existed at a specific time, without disclosing trade secrets.
For drug discovery and AI-driven modeling, this addresses a persistent problem: how to establish priority, provenance, and model output integrity without relying on internal logs, lab notebooks, or trusted intermediaries. Hash commitments allow any third party to later verify that a disclosed structure or pose matches the original result, while the public timestamp provides defensible prior-art evidence.
Importantly, this does not claim biological validation or clinical relevance. It is an infrastructure demonstration: a method for anchoring in-silico discovery outputs to a neutral, tamper-resistant record that survives personnel changes, corporate restructuring, and legal disputes.
Used this way, a blockchain functions less as a financial system and more as a public notary for computational science—particularly relevant as AI-generated results become harder to audit, reproduce, or attribute over long development timelines.
#BSV #GENUINEBITCOIN
Bryan Daugherty@BWDaugherty
🧬 @BioPrimeAI just wrote this drug discovery result to BSV blockchain: Protocol: BPRM_SOLUTION_V1 Target: CDK4/6 (breast cancer) Job ID: 3ce8cb9d-2439-4563-8777-3bdd3f3a243d Timestamp: 1769565919 (blockchain-verified) Every result includes: ✓ Protein structure hash (SHA-256) ✓ Binding pose hash (SHA-256) ✓ ECDSA signature (cryptographic proof) ✓ Immutable timestamp (prior art) Any researcher can verify this result independently. This is what blockchain-verified science looks like. Not speculation. Real drug discovery. Real blockchain utility. --> whatsonchain.com/tx/3bcc6e179c0… #BioPrimeAI #BSV #DrugDiscovery #Blockchain
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Same optimization engine powering BioPrime's 10,000x drug discovery speedup.
OriginNode proves it in blockchain.
BioPrime proves it in molecular docking.
Production-validated.
42.9% improvement under adversarial conditions speaks louder than any whitepaper. 🧬
Bryan Daugherty@BWDaugherty
Blockchain node that gets BETTER under attack? Just verified OriginNode: - +42.9% improvement under stress - 3.85s to complete - Immutable BSV proof whatsonchain.com/tx/57b1cea8977… The Daugherty Engine is real. #BSV
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@BWDaugherty 🎁 Reminder: Every signup gets $5 free credit That's 1 million compounds screened. For free. No payment required. Students, small labs, researchers anywhere—just sign up and run your campaign.
Democratizing drug discovery, one free million at a time.
Bioprime.one
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Same engine. Four domains. All live.
BioPrime: Drug discovery infrastructure
(The others handle their own domains)
This is what domain-agnostic optimization looks like when it actually works. 🧬
Try the demos ⬇️
Bryan Daugherty@BWDaugherty
Four @SmartLedgerTech platforms. One engine. All live. 🔬 #BioPrime: Drug discovery 10,000x faster 📊 #SemanticScalpel: 95% accuracy, 6ms latency ⚙️ #DaughertyEngine: The core tech behind it all ⛓️ #BSV Integration: #Blockchain-verified research Live demos on @huggingface: huggingface.co/GotThatData Proprietary tech. Production-ready. 🧬 @elonmusk @grok @xai @BrianRoemmele @clementdelangue @julien_c @osanseviero
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