BioViva USA Inc

Healthy people show a brief FGF21 drop after stress, while those with mitochondrial disease show a delayed rise. FGF21 also reflects social and emotional factors, linking stress and metabolic health. pulse.ly/ptgxwa9xga

Fasting triggers the body to shift from using glucose to burning fat and producing ketones, coordinated by hormones and liver signals like FGF21. Mice without liver-produced FGF21 still showed normal fasting metabolism, but they lost the usual increase in protein appetite

In C. elegans, the RNA that maintains chromosome ends doesn't have its own gene but is hidden inside another gene and "hitchhikes" there. This discovery may be common in animals and could inform future regenerative medicine research. pulse.ly/muyevbreel

PAX3 and PAX7 guide the development of different neural cell types in the embryonic spinal cord. This activation occurs only in cells exposed to BMP signals. pulse.ly/binepahttp

Scientists at The University of Texas at Austin have developed a revolutionary gene-editing method using bacterial retrons that can correct multiple disease-causing mutations at once. pulse.ly/j4todlehsj

"A neurologist at the University of Cambridge, used data from the massive UK Biobank resource and found a link between reduced glymphatic function and increased risk of dementia. pulse.ly/yuyisvtriz

Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy pulse.ly/rxin5r7mmf

In the poll kids generally believed 49 years old was -- old! and, "One in five children believe adults stop having fun and exercising at 30-years-old and nearly half of those polled said they believed their parents were old." pulse.ly/61y1ernsgt

“ Whether we damaged the mitochondria or the telomeres we got dysfunctional T cells. There is crosstalk between the engine of the cell and the brains of the cell, the mitochondria, and the nucleus. something we didn’t appreciate in immune system.” pulse.ly/2whls2jkze

Mounting evidence suggests telomere shortening is an important research focus in interstitial lung disease (ILD) pulse.ly/n8bv4skors

Foxo3 enhanced human mesenchymal progenitor cells pulse.ly/aamxlhfetn

Gene therapy, yes. pulse.ly/4aoqf4deyo

The Role of the Senescence-Associated Secretory Phenotype in Cardiovascular Disease Among the Elderlyhttps://pulse.ly/sa2f6qm2iy

This study is among the first to show that the first weeks of life, when the immune system is naturally more tolerant, may be the optimal window for delivering gene therapies that would otherwise be rejected at older ages. pulse.ly/ebzhdkvyzv

Genetic risk variants don’t always cause disease, and outcomes can vary among carriers. Poeschla et al. suggest this is partly due to common variants—such as those affecting telomere length— pulse.ly/jwogepgqgv

Telomere fragility is linked to telomere length and telomerase activity. Lab tests confirmed that short telomeres were more fragile, especially in clones with lower telomerase activity.pulse.ly/nck3lh7g7d

T-cell lymphopenia is a key feature of immunodeficiency in telomere biology disorders and is linked to higher risks of serious infections, cancer, and reduced survival. pulse.ly/dmh8qa16ie

Those who developed kidney problems (AKI) had lower levels of Klotho. People with higher Klotho levels had better chances of recovery. Klotho was also a better warning sign of kidney issues than the usual test (creatinine). pulse.ly/ye3cbmjeq4

Link Between Shortened Telomeres and Brain Pathology Mitigated by Modifiable Risk Factorshttps://pulse.ly/ew1sytfqjb

Double the risk? Variants in the homeostatic iron regulator (HFE) gene are prevalent among individuals of European ancestry and have been linked to an increased risk of dementia. pulse.ly/ss2s9ua7ro