Biophysical Journal

#OPENACCESS: The PAS domain directly regulates hERG channel gating in patch-clamp fluorometry recordings. Matthew C. Trudeau. buff.ly/wMjBGWN

#OPENACCESS: Protein-free membrane fusion: A refined view of the delicate fusogenic properties of calcium. Matilde Accorsi, Rachel Ní Earchaí, Naresh Yandrapalli, Shreya Pramanik, and Rumiana Dimova. buff.ly/fjy2qm5

#OPENACCESS: Shaji and Pathak investigate collective cell migration in mammary epithelial cells, revealing that LINC disruption impacts nuclear-cytoskeletal mechanics, slowing collective migration and reducing actomyosin contractility. buff.ly/In8Hdfr

#OPENACCESS: Think of the cytoskeleton like a spider web—add star-like “astral” hubs and suddenly the whole network gets tougher, resisting breaks by shifting its percolation threshold. Berg et al. reveal how cells engineer strength from structure! buff.ly/UB32COT

Steric bulk (and not the electrostatics) created by glycosylation of proteins is the root cause of their reduced endocytic uptake—the study finds. buff.ly/ZrAmjvB

Special issue call for papers: Single-Molecule Approaches to Reveal Structural and Mechanistic Properties of the Genome. buff.ly/34cLMw6

#OPENACCESS: How does RBC rigidity impact blood flow? Rashidi et al. show in vivo that increased rigidity reduces average transit time, reshaping flow at microvascular bifurcations. buff.ly/8qjggYG

Special issue call for papers: Foundations of Membrane Biophysics: Dedicated to Wolfgang Helfrich. buff.ly/g8n6AXw

#OPENACCESS: Chaperone proteins protect against desmin fragment amyloid aggregation. Erin M. Mulhearn and Ariel M. Alperstein. buff.ly/ejeGJ9D

In the New and Notable "Rethinking contractility in active cytoskeletal matter," Tamara C. Bidone highlights the paper "Nonuniform filament turnover, contractility, and bundle formation in disordered actomyosin networks." buff.ly/fo7liVM

#OPENACCESS: Biomolecular condensates behave less like water, more like slime in a lava lamp: stretchy, flowing, yet structured. Zhang et al. use “computational rheometry” to probe their squish & stretch, revealing how cells tune mechanics inside. buff.ly/B4OHcYv

#OPENACCESS: Consecutive prolines and polyproline II helices stabilize features in PRD domain, making the p53 structurally dynamic—a requirement for the tumor suppression function of p53. This dynamic is compromised in disease variants. buff.ly/P1aenha

Special issue call for papers: Physical Properties of Cells: From Measurement to Medicine, A Tribute to Jochen Guck. buff.ly/CIiCPrw

In the New and Notable "When the nucleus disconnects, cells lose their way," Tanmay P. Lele highlights the paper "Disruption of nuclear-cytoskeletal connection impairs epithelial cell mechanosensing and collective migration." buff.ly/FskUmHa

Tam and colleagues use mathematical modelling to show how different modes of actin turnover influence contractility in disordered actomyosin networks, revealing how nonmuscle cells tune force through varying actin turnover pathways. buff.ly/fo7liVM

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: buff.ly/dMaXw2y

#OPENACCESS: Continuum and discrete modeling of binding-site distribution-mediated reactions on lipid surfaces. Han Cao, Anirban Sen Gupta, and Karin Leiderman. buff.ly/sXaclMD

#OPENACCESS: Mechanisms of thrombin inhibition by protein S and the TFPIα-fVshort-protein S complex. Alexander G. Ginsberg, Josefin Ahnström, James T.B. Crawley, Karin Leiderman, Dougald M. Monroe, Keith B. Neeves, Suzanne F. Sindi, and Aaron L. Fogelson. buff.ly/776MSnZ

#OPENACCESS: A tunable, ultrasensitive threshold in enzymatic activity governs the DNA methylation landscape. Kwadwo A. Bonsu, Nandor Laszik, Annie Trinh, Timothy L. Downing, and Elizabeth L. Read. buff.ly/M6QOAWL

#OPENACCESS: Quantifying the effect of magnesium ions on nucleosome stability in chromatin fibers. Luuk J.C. Daris, Lieke A. Lamers, Kes van Blitterswijk, Camila Delgado Zuvanic, and Jorine M. Eeftens. buff.ly/61RbxbN