Sigurbjörn Markússon

First data from my PhD out now in preprint! Turns out that the orphan SLC45A4 is a polyamine transporter involved in pain signalling, that contains a novel autoinhibitory plug domain biorxiv.org/content/10.110…

Nature research paper: SLC45A4 is a pain gene encoding a neuronal polyamine transporter go.nature.com/4lI8GId

Structural basis for antibiotic transport and inhibition in PepT2 | Nat Commun doi.org/10.1038/s41467…

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter | bioRxiv biorxiv.org/content/10.110…

A great team effort in the @inwardopen lab, in fantastic collaboration with the Bennet lab @MiddletonSJ_ and others, including @LeaLabTweets @justindeme85

First data from my PhD out now in preprint! Turns out that the orphan SLC45A4 is a polyamine transporter involved in pain signalling, that contains a novel autoinhibitory plug domain biorxiv.org/content/10.110…

Latest preprint from the group has landed - Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter. biorxiv.org/content/10.110… A great team effort involving researchers from around the world! @LeaLabTweets @wellcometrust

Congratulations to our new Dr Löbel! @BiochemOxford @KavliOxford thanks to Paul @Elliott_Lab_Ox and David Drew

new release5 8P6A: cryo-EM structure of human SLC15A4 in outward-open state Newstead lab.

Excited to share our most recent work on the giant ubiquitin ligase #BIRC6 out now in @ScienceMagazine science.org/doi/10.1126/sc…!   Thread below 🧵 (1/7)

Congratulations 🎉 Dr Kolokouris! Newly minted DPhil for @BiochemOxford @KavliOxford

Alkaline phosphatases (APs) use various methods to adapt environmentally. Hjörleifsson, @BjossiM and colleagues @uni_iceland @UniOulu @UiB show an AP from the marine bacterium Vibrio splendidus has two Cl binding sites which seem to play different roles. pubs.acs.org/doi/10.1021/ac…

@inari_kursula @petrikursula Yes, I have, and I was terribly sorry to hear. I think his memory may live on for a long time in the crystallography lab at UiB ♥️

Ever wondered how enzymes adapt to cold and saline environments? Then our new paper on the structural basis for chloride activation/stabilization of a marine bacterial phosphatase might be of interest! Out now in @BiochemistryACS pubs.acs.org/doi/10.1021/ac…

And last but not least, a huge shoutout to Tony the Pony (pictured below, @petrikursula @inari_kursula), who supplied wonderful pony hairs that allowed for streak seeding some of the beautiful (atomic resolution) crystal we used in this study!

Thanks to the twitterless Jens, @basgeirsson @PetriKursulaLab and @Neurotarget_UiB for a great collaboration

Great to see Mark's paper out rdcu.be/cTQje - The structural basis for cystine transport via cystinosin! Further insights into lysosomal transport and evolution of the PQ-loop family! Congrats to Sacha, Kamel and Jo with @ProfKalium providing ePhys support!

Our new paper on Arc is out now in @PLOSONE! We used Nb-aided crystallography, SAXS and simulations to look at the dynamic CTD, and found a surprising inhibitory Nb. Thanks to @PetriKursulaLab @yesthisisarne @Neurotarget_UiB and everyone else involved! journals.plos.org/plosone/articl…

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Mikið djöfull sem það verður gaman að fá @KRHandbolti í #Olísdeildin á næsta vetri. Til hamingju. twitter.com/krhandbolti/st…