Bone & Joint Research

This month's featured author is @klogishetty, Consultant Orthopaedic Surgeon at @uclh. Check out his recent review on the state of the art in radiomics for femoroacetabular impingement and its future applications! #BJR #OrthoTwitter #FOAMed #Research ow.ly/VQYo50YvVAj

The screw-supported prosthesis shows potential for severe acetabular defects, but the screw-cup connection remains a vulnerable site. #Biomechanics #Arthroplasty #Surgery #BJR ow.ly/HGNs50YwOLX

"... often necessitate revision surgeries". 👩‍⚕️ This week, we break down a new in vitro study on  how the timing & concentration of povidone-iodine affect bacterial eradication during surgery. Check out the episode now! #BJR #AITalks #Podcast #Surgery ow.ly/cY7650YwTAP

The aim of this study was to assess the diagnostic accuracy of albumin-to-globulin ratio & CRP-to-albumin ratio in diagnosing periprosthetic joint infection & to compare them to the established and widely used marker CRP. #Infection #Research #FOAMed ow.ly/J30S50YtpGI

The results of this study underscore the translational value of ergothioneine as an early preventive strategy for oestrogen-deficient osteoporosis. #Osteoporosis #Biology #Inflammation #BJR ow.ly/2O2g50YvsLo

⏰ FRACS (Ortho) exam in three weeks time? | 📝 Practise answering Single Best Answer MCQs Taking your FRACS (Ortho) exam on 9th April? It's the perfect time to make sure you know how to approach SBA questions. You'll find 1400+ MCQs on #BJJLIFE. #FRACS ow.ly/HGhR50YvnkN

Signal transducer and activator of transcription 3 was identified as a highly expressed gene common to both #osteoporosis and #sarcopenia through weighted gene coexpression network analysis. #OrthoTwitter #StemCells #OpenAccess ow.ly/gktU50Ytp40

This study demonstrates ability of the trained model to identify neutrophils in tissue taken at revision surgery and could assist in the diagnosis of periprosthetic infection. #OrthoTwitter #Infection #AI #Surgery #BJR ow.ly/m7ui50Yvsmt

New episode live! ✨ In our latest #AITalks discussion, we dive into a recent paper providing insights into the optimal protocols for using diluted povidone-iodine for intraoperative irrigation. Hear the discussion below! #Infection #Research #Ortho ow.ly/4QWf50Yvr8w

This aim of this study was to analyze the detection rate of rare pathogens in bone & joint infections using metagenomic next-generation sequencing (mNGS) & the impact of mNGS on clinical diagnosis & treatment. #BJR #Infection #Microorganisms #Orthopedics ow.ly/o8Qp50YtoCu

By binding with receptor for advanced glycation end products (RAGEs), AGEs can activate a series of intracellular signalling pathways in skeletal muscle cells related to the elevated levels of inflammation and oxidative stress. #Sarcopenia #Research #BJR ow.ly/9JnX50YpfeR

In this population-based cohort study, low-density lipoprotein cholesterol lowering was associated with a decreased risk of fracture in individuals with hyperlipidaemia. #Bone #Fracture #Research #OrthoTwitter #BJR ow.ly/Q6C150YrciE

This study investigated the protective effect of orientin on osteoarthritis through a series of in vitro and in vivo experiments. #Arthritis #Disease #Pain #OpenAccess #BJR ow.ly/XR2350Ypf2x

🗓️ Less than three months to go | 📝 Practise your FRCS exam technique If you're taking your #FRCS (T&O) exam on 3rd June, there's still time to make the most of a three-month subscription to #BJJLIFE! Sign up now to get instant access to 1300+ #MCQs. boneandjoint.org.uk/life/

We demonstrated that nuclear factor kappa B decoy oligodeoxynucleotides increased osteogenesis in male mice and decreased bone resorption activity in both sexes in preclinical models of chronic inflammation. #Inflammation #Therapy #OrthoTwitter #BJR ow.ly/H13p50YpfsK

CXCL5 is highly expressed in Gram-positive bacterial component-associated periprosthetic joint infection (GPC-PJI) and protects bone by inhibiting osteoclast differentiation through PLCγ2 and c-Fos signalling. #BJR #Bone #Biology #Infection #Patients ow.ly/Sz5k50Ypaz5

Based on the scope of this study, no significant toxic side-effects were found after the intravenous combined with local high-concentration continuous use of antibiotics. #Antibiotics #Infection #Surgery #BJR ow.ly/eYM850Yn3Wz

This study demonstrates that in screw-supported prosthesis reconstruction for severe acetabular defects, the connection sites between the posterior iliac/pubic screws & the acetabular component are critical weak points prone to fatigue failure. #BJR ow.ly/R8EP50Yp9fK

"...detailed insights and practical recommendations." Tune into our recent #AITalks episode as we unpack the methodological rigour of ovine lumbar interbody fusion studies and highlight further findings! #BJR #Podcast #Spine #Research #MedTwitter ow.ly/YAxP50Yp8os

"Hyperactive CREB1 (cAMP responsive element binding protein 1) played a critical role in OA development, and 666-15 exerted anti-IL-1β or anti-CCCP effects in vitro as well as joint-protective effects in vivo. 666-15 may therefore be used as a promising anti-OA drug."