Brain Inflammation Collaborative

Numerous chronic conditions, such as Long COVID, ME/CSF, and POTS, share common characteristics such as: - neuroinflammation - overlapping immunopathologies - overlapping symptoms & comorbidities - variable responses to medical treatments These conditions are also associated with in increased risk of psychiatric conditions including depression. That's why we wrote a free white paper, with 118 peer-reviewed sources, to challenge the way patients and health professionals view the impact chronic inflammation and our mental health. Access it here 👇 buff.ly/FqLJ4Zo

@NationalAnthemX @sciqst To my knowledge, there are no licensed drugs. There is at least one clinical trial for a drug designed to kill senescent endothelial cells.

@sciqst @BrainInflCollab When you say "targeting endothelial health"...are there really concrete treatments? Or...is this just...identifying a grave problem that has no solution? Thanks:)

Endothelial senescence may be one of the most overlooked drivers of Long COVID and ME/CFS. Could it kickstart a domino effect that leads to the symptoms observed by a subset of patients with: - Long COVID - ME/CFS The same research group that first discovered microclots in Long COVID argues that the answer is yes. In this article, we explore how endothelial senescence and its harmful secretions (known as the senescence-associated secretory phenotype, or SASP) can drive the wide-ranging, tissue-specific symptoms affecting millions of people with these conditions. braininflcollab.substack.com/p/the-second-d…

@manninglawrence @Innov_Medicine @The_InnovationJ @DrMakaryFDA @SecKennedy We need more antivirals. We also need one for EBV!

@BrainInflCollab @Innov_Medicine @The_InnovationJ Lets prioritize a damn antiviral that gets damn CNS tissue penetration to kill Covid. We have 18 fn drugs to lose weight and not 1 fn antiviral that penetrates the BBB at clinical levels. I mean, is the world nuts. @DrMakaryFDA @SecKennedy

NEWS & BUZZ #COVID19 Pandemic: End of emergency, but not end of challenge @innov_medicine @The_InnovationJ More details: the-innovation.org/article/doi/10…

@manninglawrence Ah, good point!

@BrainInflCollab Yes but SASP goes on to trigger the IDO inflammation trap. The SASP cytokines are exactly the same as the IDO activating cytokines: IL-6, IL-1β, TNF-α, and IFN-γ. This argument of which came first the chicken or the egg is dumb, if you cant get viral and inflammatory clearance

Inflammation can stimulate the production of quinolinic acid, a neurotoxic metabolite. This is reported to occur in a range of conditions, including but not limited to: - ME/CFS (1) - Long COVID (2) - Parkinson’s disease (3) - Alzheimer’s disease (4) - Traumatic brain injury (5) - Concussions (5) - Major depressive disorder (6) - Bipolar disorder (6) - Schizophrenia (6) - Mood disorders (7) - Suicidal ideation (8) Here is the science in simple terms 👇️ braininflammation.org/kynurenine-pat… Literature Cited: 1. Kavyani B, Lidbury BA, Schloeffel R, et al. PMID: 35821534 2. Bizjak DA, Stangl M, Börner N, et al. PMID: 36211365 3. Venkatesan D, Iyer M, Narayanasamy A, Siva K, Vellingiri B. PMID: 33134567 4. Liang Y, Xie S, He Y, et al. PMID: 35096208 5. Dehhaghi M, Heng B, Guillemin GJ. PMID: 37360356 6. Marx W, McGuinness AJ, Rocks T, et al. PMID: 33230205 7. Arnone D, Saraykar S, Salem H, Teixeira AL, Dantzer R, Selvaraj S. PMID: 29940237 8. Bryleva EY, Brundin L. PMID: 26820800

Ongoing inflammation and low blood iron levels (leading to anemia & disrupted red blood cell production) appeared as early as 2 weeks post-COVID in those who later developed long COVID. Read more: news-medical.net/news/20260306/…

As Long COVID emerged in many, scientists could look back to early blood markers that predicted it. They analyzed samples from 214 people. ~45% reported long COVID symptoms 3–10 months later. Here's what they found.

Some bounce back after a symptomatic SARS-CoV-2 infection. Others develop Long COVID. New research finds a clue that might explain why...🧵

@itssuzann Hope you are able to one day. 🤞

@BrainInflCollab Yes! I’d definitely volunteer. I’m have ME. I studied biochemistry at university. So I’m very very interested.

Mitochondrial dysfunction is a hallmark of many chronic conditions, including, but not limited to: - MS - Lupus - ME/CFS - Long COVID - Bipolar Disorder - Major Depression - Traumatic Brain Injury A new method donates healthy mitochondria to disease-affected cells...🧵

Understanding this biology is not only important for parents but also for all healthcare professionals. The impact of chronic inflammation on the brain might also explain why adults with chronic inflammatory conditions are at increased risk of developing psychiatric conditions compared to healthy controls. Let us know what you think by dropping a comment below.

But why are ACEs linked to an increased risk of autoimmunity? Persistent systemic immune dysregulation, attributed to the chronic inflammation, can reduce the immune system's ability to recognize self from non-self targets. This can directly increase risk for various autoimmune disorders.

Traumatic childhood experiences are associated with an increased risk of: - depression - autoimmune conditions Examples include, but are not limited to: - child abuse - domestic violence - parental separation Here is the science in simple terms...🧵

This technology would be a game-changer for so many in our audience impacted by IACCs, neuroinflammatory, and neurodegenerative diseases. However, many unanswered questions will take years to address. Let us know if you would be willing to volunteer for such a clinical trial by dropping a comment below. Also, check out our Substack for more content like this: @braininflcollab?utm_campaign=profile&utm_medium=profile-page" target="_blank" rel="nofollow noopener">substack.com/@braininflcoll…

They also mentioned they will use humanized nanobodies if/when MitoCatch is tested in humans. Humanized nanobodies are less likely to elicit an adaptive immune response. This means the therapy could be used more than once because antibodies wouldn't attack the foreign nanobodies following the initial infusion (or injection).