Broderick Lab

The [4Fe-4S] Cluster of HydF Is Essential for [FeFe]-Hydrogenase Maturation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Fantastic research group camping outing last weekend: two nights of a northern lights show, a beautiful float and card games. Perfect weather only a few days after an 8” snow storm. @BroderickLabFeS

Check out our #potw! Thanks Alina for presenting this cool work about a radical SAM epimerase by the Broderick lab. Read to learn how a conserved Cys to Ser mutation helped trap and characterize the α-C • intermediate of OspA using rapid quench & EPR pubs.acs.org/doi/10.1021/ja…

Congrats to @AnnaVagstad bringing this amazing story to the finish line! Thank you to everyone involved from @BroderickLabFeS for the fantastic collaboration! If you are interested in the enzymatic mechanism of peptide epimerization by rSAM, make sure to read it.👇

Kudos to grad student Will Walls @BroderickLabFeS on outstanding work that led to his first @J_A_C_S paper! Congrats also to undergrad Tyler Delridge, Will Broderick, and collaborators @AnnaVagstad and @piel_lab. Radical epimerization in RiPP maturation.

We showed that upon reductive SAM cleavage, the 5’-dAdo radical moves *towards* the [4Fe4S] cluster, on its way to forming the omega organometallic intermediate. The once elusive radical, triangulated! @BroderickLabFeS @MartinMosqueraT

ENDOR Spectroscopy Reveals 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site is Chaperoned by Interaction with Methionine-Bound [4Fe–4S]2+ Cluster JACS @montanastate @NUChemistry @Northwestern #ENDOR #Adenosyl #Radical #Methionine #Chaperone pubs.acs.org/doi/10.1021/ja…

New in ChemComm: @joanbroderick and colleagues report the semisynthetic maturation of [FeFe]-hydrogenase, revealing new insights into the nature of H-cluster biosynthesis. @BroderickLabFeS bit.ly/46W7lHy

Computational Description of Alkylated Iron–Sulfur Organometallic Clusters | Journal of the American Chemical Society @montanastate @msuchembiochem @ResearchNU @NorthwesternU @NUChemistry #Computational #Alkylated #IronSulfur #Organometallic #Clusters pubs.acs.org/doi/10.1021/ja…

A new mini review from our lab focusing on in vitro [FeFe]-hydrogenase maturation. Interesting chemistry & biochemistry with still so much to learn!

Happy to share our most recent review on radical SAM enzymes: FEBS Press febs.onlinelibrary.wiley.com/doi/10.1002/18…

We have a fantastic department with so many amazing young faculty - come work in this stimulating and collegial community! Bozeman is not bad either!

.@joanbroderick & gang review [FeFe]-hydrogenase in vitro maturation. Out now with @angew_chem! doi.org/10.1002/anie.2…

We are working hard at the Metallocofactors GRC! #Metalloco22

Congrats to Katherine on graduating today with a B.S. in Chemistry/Biochemistry. She has been an awesome research student and lab mate and we will miss her!

Dana Longcope of @montanastate has been elected to the National Academy of Sciences for research on the nature of solar magnetism, and magnetic topology. #NAS159 Read more: ow.ly/n3sV50IYEuX #physics

Congratulations to Joan B. Broderick of @montanastate who joins the National Academy of Sciences for her outstanding contributions to biochemistry. #NAS159 Read more: ow.ly/jMFs50IYzho #biochemistry

Congratulations to Joan on election to the American Academy of Arts & Sciences! @americanacad @joanbroderick @msuchembiochem @montanastate

A grad student interested in teaching positions? A post-doc looking to diversify? The @BUChemistry PAL program has been a successful way for training toward a PUI position! We are looking for 3 new PALs. You'll have a research and a teaching mentor! academicjobsonline.org/ajo/jobs/21306

[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis (Broderick) @BroderickLabFeS onlinelibrary.wiley.com/doi/10.1002/an…