Caroline McCormick retweetledi

1/6 🧬New paper at @CellSytemsCP led by @SashaFanari! What if the “fifth nucleotide,” pseudouridine (Ψ), in mRNA dynamically responds to cell state? We used nanopore direct RNA sequencing + Mod‑pID to map Ψ in a neuron‑like SH‑SY5Y line under “normal” and “perturbed” conditions (healthy, RA‑differentiation and unhealthy, neurotoxicant Pb2+poisoning).

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