Clinical & Experimental Immunology

New review shows how, in Sjögren’s syndrome, salivary gland epithelial cells act not just as targets but as drivers of autoimmune inflammation. Their altered signalling and antigen‑presenting features can shape and sustain immune dysregulation. 🔗 vist.ly/4v6eg

🔬 Open‑access study investigates how neutrophils contribute to multiple sclerosis. Using proteomics, it reveals altered granule proteins, shifts in pro‑inflammatory signalling, reduced T‑cell suppression, and enhanced Th17 differentiation in MS. Read: doi.org/10.1093/cei/ux…

🧪 Study shows Staphylococcus aureus exotoxin SEB can bind and activate the immune receptor 2B4, driving allergic inflammation. 2B4‑KO mice showed reduced inflammatory responses, suggesting 2B4 as a potential therapeutic target. 🔗 bit.ly/4my2B1e

🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk. 🔗 bit.ly/3JfJag1

IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. bit.ly/4qs1hyZ

Highlighting this article that explores an alternative way of assessing mTOR inhibition therapy following kidney transplantation. Read the article here: bit.ly/4kyQn9w

Celebrating #February11 by highlighting Professor Claudia Mauri, the Editor‑in‑Chief of @CEIjournal Her leadership and expertise continue to shape the future of immunology. Read the interview on the BSI website here: bit.ly/4abuedR #WomenInScience

This #WorldCancerDay, explore how bispecific T‑cell engagers (BiTEs) could strengthen T‑cell responses against solid tumours, and the challenges still holding them back. Read the open access review: bit.ly/4291Ipg #CancerResearch #Immunotherapy #BiTEs

🔬Maria Filika & Stergios Katsiougiannis explore how salivary gland epithelial cells in Sjögren’s syndrome actively drive and amplify autoimmune responses, reshaping how we view target tissues in autoimmunity. Read the open access review: bit.ly/4k6LOTH

📢 We’re welcoming high‑quality translational immunology submissions! If your research offers novel mechanistic insight into human disease, we want to hear from you. Submit your work: bit.ly/3LjuI2A

🔬 Jan Devan et al. identify distinct pro‑inflammatory T‑cell populations in Crohn’s disease lesions, including CD4⁺CD39⁺ TCRαβ⁺ cells and activated TCR Vδ1⁺ cells, highlighting potential new therapeutic targets. Read the article: bit.ly/3LitpGu #CrohnsDisease

📘 See CEI’s top-performing papers of 2025! Explore our 2025 must‑read articles, highlighting impactful immunology research Read more: bit.ly/45ELeXc

MOG/NMDAR overlapping syndrome is increasingly recognised. This review shows common symptoms (psychiatric changes, seizures), typical MRI patterns, good treatment response, but a notably higher recurrence rate. Read here📄 bit.ly/3Q2S29A

Crohn’s disease lesions show enrichment of CD4⁺CD39⁺ TCRαβ⁺ TEM cells producing IL‑17/IL‑21 and terminally differentiated TCR Vδ1⁺ cells producing TNF‑α/IFN‑γ. Distinct inflammatory roles point to Vδ1⁺ cells as a potential therapeutic target. 📄 bit.ly/3LitpGu

Despite elevated KLR and mitochondrial gene expression, Tregs in autoimmune PAI show normal frequency and suppressive function, suggesting limited involvement in disease pathogenesis. 📄 bit.ly/3Q2QVGU

Working in immunology? Clinical & Experimental Immunology publishes impactful studies across six core sections plus areas like immunometabolism, mucosal immunity, and immunotherapy. Learn more about submitting your next manuscript to CEI: bit.ly/443pf8s

Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity. 📄 bit.ly/3rzemhN

This study highlights 2B4 (CD244) as a key receptor driving Staphylococcus aureus–associated allergic inflammation. SEB binds and activates 2B4, amplifying eosinophil responses, pointing to a promising therapeutic target. 📄 bit.ly/4my2B1e

Happy holidays from all of us! ❄️✨ Thank you to our authors, reviewers, and readers for another great year. We look forward to welcoming your submissions in the new year!

Delighted the 2nd paper from @GraceFilbertine is now online @CEIjournal we performed multiomics analysis of #neutrophils from adult and pediatric #SLE patients - similarities & differences reported @LivuniILCaMS @ChulalongkornU @ellielou_uk @LivUniNMR academic.oup.com/cei/article/21…