Clinical & Experimental Immunology

Organoid co-culture and organ-on-chip systems are transforming how we study immune–epithelial interactions, enabling more precise, patient-relevant models of disease 🧬 🔗 doi.org/10.1093/cei/ux… #Immunology #Organoids #Microfluidics #PrecisionMedicine

Research in Crohn’s disease shows peripheral blood T cells are already less prone to apoptosis before reaching the gut, with reduced catalase activity contributing to this effect 🧬 🔗 doi.org/10.1093/cei/ux… #Immunology #CrohnsDisease #Tcells

A simpler, highly specific way to detect AIH? This study shows that MF-SMA patterns on vascular smooth muscle cells are easy to recognize and match gold-standard specificity, offering a more reliable diagnostic approach. 🧬 doi.org/10.1093/cei/ux…

Early splenectomy delays inflammation and reduces joint damage in a mouse model of autoimmune arthritis, highlighting a surprising protective role when done at early stages. 🧬 doi.org/10.1093/cei/ux… #Immunology #Autoimmunity #Arthritis

📢 New open‑access study identifies PSMB8 as a biomarker predicting proton pump inhibitor response in pediatric eosinophilic esophagitis, supporting more personalized treatment decisions. 🔗 doi.org/10.1093/cei/ux…

📢 Autoimmune overlap spotlight: MOG‑IgG and NMDAR‑IgG can coexist, causing MNOS, often presenting with psychiatric symptoms or seizures. Most patients respond to immunotherapy, but relapse risk is higher, making early recognition crucial. 🔗 doi.org/10.1093/cei/ux…

🫁 #WorldAsthmaDay Open‑access research reveals how reduced IL‑10 from FoxP3⁺ Treg cells in allergic eosinophilic asthma may be partially compensated by CD46‑driven FoxP3⁻ IL‑10⁺ regulatory T cells, shedding light on immune balance in asthma. 👉 doi.org/10.1093/cei/ux…

🧬 A rare SCID case highlights the complexity of inborn errors of immunity, showing how concomitant RAG‑2 and LRBA variants can coexist and why functional immunological testing is crucial when interpreting novel genetic findings, even years post‑HSCT. 👉 vist.ly/42fic

This study highlights 2B4 (CD244) as a key receptor driving Staphylococcus aureus–associated allergic inflammation. SEB binds and activates 2B4, amplifying eosinophil responses, pointing to a promising therapeutic target. 📄 bit.ly/4my2B1e

This new open‑access study shows the β‑blocker nebivolol prevents T‑cell exhaustion and boosts cytotoxicity against breast cancer cells via β₂‑adrenergic receptor–dependent signalling, highlighting a potential new immunomodulatory strategy. vist.ly/4zh43

Open‑access review shows how immunotherapy has transformed advanced melanoma treatment, with many patients now likely cured, and highlights emerging options for those who don’t respond to current therapies. doi.org/10.1093/cei/ux…

Neutrophil extracellular traps (NETs) are emerging as both biomarkers and drivers of rheumatoid arthritis, linked to disease activity, treatment response and key pathogenic pathways. Targeting NET formation could open new therapeutic avenues in RA. doi.org/10.1093/cei/ux…

IFNγ from activated CD4⁺ T cells plays a key role in driving lupus by promoting B‑cell differentiation and autoantibody production. Mice lacking IFNγ showed reduced symptoms, highlighting these cells as a potential therapeutic target. doi.org/10.1093/cei/ux… #Immunology

New study by Burke et al. shows oral vaccines perform less effectively in high‑burden settings due to maternal, host and environmental factors, highlighting the need for targeted strategies to boost effectiveness. Read here: doi.org/10.1093/cei/ux… #CelebrateVaccines

New review shows how, in Sjögren’s syndrome, salivary gland epithelial cells act not just as targets but as drivers of autoimmune inflammation. Their altered signalling and antigen‑presenting features can shape and sustain immune dysregulation. 🔗 vist.ly/4v6eg

🔬 Open‑access study investigates how neutrophils contribute to multiple sclerosis. Using proteomics, it reveals altered granule proteins, shifts in pro‑inflammatory signalling, reduced T‑cell suppression, and enhanced Th17 differentiation in MS. Read: doi.org/10.1093/cei/ux…

🧪 Study shows Staphylococcus aureus exotoxin SEB can bind and activate the immune receptor 2B4, driving allergic inflammation. 2B4‑KO mice showed reduced inflammatory responses, suggesting 2B4 as a potential therapeutic target. 🔗 bit.ly/4my2B1e

🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk. 🔗 bit.ly/3JfJag1

IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. bit.ly/4qs1hyZ

Highlighting this article that explores an alternative way of assessing mTOR inhibition therapy following kidney transplantation. Read the article here: bit.ly/4kyQn9w