Cristina Hernando retweetledi
At #SABCS25, we presented results from the PremiÈRe study (SOLTI-2104), the first trial to evaluate the use of the oral drug elacestrant in premenopausal women with early HR+/HER2- breast cancer, led by @BelletMeritxell
Over four weeks of preoperative treatment, the study shows:
• a significant reduction in tumor proliferation,
• molecular changes shifting tumors toward lower-risk profiles,
• and comparable biological activity between elacestrant monotherapy and its combination with ovarian suppression.
These findings provide the first evidence that oral SERDs could become an effective and potentially less toxic endocrine alternative for young women, a group historically underrepresented in clinical trials.
🔎 This advance continues the line of research led by SOLTI to explore endocrine de-escalation strategies grounded in real tumor biology.
📄 You can read the full press release here:
gruposolti.org/the-premiere-s…
#beSOLTI #SABCS25
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