Camilla Schytz

News from our lab: 4 weeks of high altitude decreases human skeletal muscle mitochondrial cristae density, while mitochondrial respiration increases: doi.org/10.1152/japplp… Carsten Lundby, @DrRajacobs, @JoachimNielsen6, @nortenblad, Stine Lundby @sduiob @teamdanmark

We are ready to scale up glycogen analysis using electron microscopy. By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies. Details below 👇

Research Article by @CSchytz et al. (@nortenblad @JoachimNielsen6 @DrRajacobs) Effect of #highaltitudeexposure on #skeletalmuscle #mitochondrial #subcellulardistribution, #ultrastructure, and #respiration in sea-level residents ow.ly/U62N50WzF12

Join our PhD course in metabolism and EC coupling. November 10-15. University of Southern Denmark. Enrol here: sdu.dk/en/forskning/p…

Our sea-level friends at @SyddanskUni provide today's #ArticleinPress, Effect of high-altitude exposure on #skeletal #muscle mitochondrial subcellular distribution, ultrastructure and respiration in sea-level residents (Camilla Tvede Schytz et al.): ow.ly/QSc550Wq3hH

Unhappy muscle mitochondria can look like this nature.com/articles/srep3…

I am thrilled to share one of the first major works from my postdoc in Amsterdam, "Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity", published online yesterday in @AgingCell onlinelibrary.wiley.com/doi/10.1111/ac…. A thread:

@RichieGoulding1 Thank you so much! Interesting! I will keep an eye on the final version 😀

@CSchytz Nice work! Although not interventional change in same subjects, we recently showed reduced cristae density in middle aged humans. Final version should be online in a week or so. Will be interesting to see how these changes are regulated in the future! researchgate.net/publication/38…

New preprint, the first after my my PhD. Link to article: biorxiv.org/content/10.110… We investigate how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, respiratory control, and intrinsic mitochondrial respiratory capacity. 1/6

How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes? Segregation into distinct populations — one that makes energy-storing ATP molecules and one that does not — could explain it nature.com/articles/d4158…

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site | Science Advances science.org/doi/10.1126/sc…

Our latest paper on aging is finally out in @ExpPhysiol. This is a real IHC tour de force on muscle morphology, satellite cells, capillaries and innervation status so if you are into that, check it out! @SebastianEdman @MobergPhD @andyphilp_lab @WiApro physoc.onlinelibrary.wiley.com/doi/full/10.11…

Is mitochondrial morphology important for cellular physiology?: Trends in Endocrinology & Metabolism cell.com/trends/endocri…

Thanks to Carsten Lundby, @DrRajacobs, @JoachimNielsen6, @nortenblad, and Stine Lundby for their expertise and dedicated work. @sduiob @teamdanmark 6/6

If supported (the 95% confidence intervals included trivial effects), our results suggest that high-altitude exposure enhance the respiratory efficiency of the mitochondrial network. 5/6

Happy to see that our comprehensive meta-regression, "Effects of Exercise Training on Mitochondrial and Capillary Growth in Human Skeletal Muscle," by @Skattebo_Oyvind, @AlmquistNicki, and myself, is now published in @SportsMedicineJ! 🎉more details soon! link.springer.com/article/10.100…

A study reveals that the distance between the endoplasmic reticulum and mitochondria is crucial for optimal mitochondrial Ca2+ uptake and oxidative metabolism. This is an important finding in terms of muscular energy efficiency.🔬 nature.com/articles/s4200…