CTCF Papers 📚

Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/53… It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.

Footprint-C reveals transcription factor modes in local clusters and long-range chromatin interactions [Liu et al, 2024] nature.com/articles/s4146… ▶️At one-dimensional level - modes of TF co-occupancy ▶️At pairwise contact level - multiway chromatin interactions of different TFs

CTCF binding landscape is established by the epigenetic status of the nucleosome, well-positioned relative to CTCF motif orientation biorxiv.org/content/10.110…

Our new CTCF breakthrough ms has been posted today at doi.org/10.1101/2024.0… with the following Graphical Abstract:

Factors that determine cell type–specific CTCF binding in health and d... sciencedirect.com/science/articl…

1/ 🤔 Do #chromatinlooping-mediated promoter-#enhancer interactions drive gene expression? Or is the local enrichment of transcription factors into hubs/#condensates the key factor? Our AC/DC model of gene regulation at bioRxiv doi.org/10.1101/2024.0… provides a new view on this.

We have an opening for a three-year postdoctoral position for a researcher with expertise in machine learning and genome bioinformatics, to work on cancer diagnostics (liquid biopsies). Please apply here: vacancies.essex.ac.uk/tlive_webrecru…

Registration (free!) and abstract submission now open! Please, spread the word. gate.essex.ac.uk

Nucleus is looking for a new Editor-in-Chief. Nucleus is a fully Open Access journal by @tandfonline. Application deadline October 18, 2024 Further information including requirements and application process can be found here: think.taylorandfrancis.com/editor_recruit…

The amazing coincidence between the topology of CTCF binding sites within Hox clusters and two major transitions in the vertebrate body plan. 🙏 Hocine @Hocine_Rekaik @cdf1530 @the_Node @CTCF_Papers #FlattenedEmbryo sciencedirect.com/science/articl…

Happy to share! Our latest publication in Genome Biology unveils how BORIS/CTCFL epigenetically reprograms transcriptionally inactive intronic CTCF sites into alternative promoters: genomebiology.biomedcentral.com/articles/10.11…

Locus folding mechanisms determine modes of antigen receptor gene assembly dlvr.it/T16hBL

DNA-sequence and epigenomic determinants of local rates of transcription elongation dlvr.it/T15vcC

LncRNA SLC7A11-AS1 stabilizes CTCF by inhibiting its UBE3A-mediated ubiquitination to promote melanoma metastasis dlvr.it/T15vbR

Benchmarking DNA binding affinity models using allele-specific transcription factor binding data dlvr.it/T15vXh

Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies dlvr.it/T12ZF1

CTCF regulates hepatitis B virus cccDNA chromatin topology dlvr.it/T0ynnV

Multi-omics computational analysis unveils the involvement of AP-1 and CTCF in hysteresis of chromatin states during macrophage polarization dlvr.it/T0yS21

A study on genotypes and phenotypes of short stature caused by epigenetic modification gene variants dlvr.it/T0xMQ8

The counterpart congenital overgrowth syndromes Beckwith-Wiedemann Syndrome in human and large offspring syndrome in bovine involve alterations in DNA methylation, transcription, and chromatin configuration dlvr.it/T0xMQ5