Carmelo Tuscano🇮🇹🇪🇺

What about supportive care with corticosteroids for these patients in the concomitant setting 🤔. Coud this affect the efficacy of Nivolumab; is there a precise threshold of steroids that investigators permitted to use? Any author around ? #radonc

NIVOPOST-OP (GORTEC): adding nivolumab to postop CRT in high-risk resected LA-SCCHN improves DFS (HR 0.76). Masked imaging review diluted the effect (HR 0.89) due to high false ± rates in post-RT neck (fibrosis vs relapse). Clinical/pathologic assessment remains key. #RadOnc #HNC

A symptomatic vertebral hemangioma treated with decompressive laminectomy + stabilization + post-op RT (45 Gy/25 fx). Excellent MRI response and recovery from paraparesis—another reminder of the value of RT in select benign conditions. #radonc ⚡

The accompanying editorial adds a layer: supramaximal surgery may change biology, but its real-world impact depends on anatomy, expertise, and system-level quality. A powerful reminder that maximal resection is not just evidence — it’s context, capability, and responsibility.

This figure tells the whole story: in IDH-mutant grade 2 gliomas, every cm³ matters. Residual T2-FLAIR volume shows a clean, continuous HR gradient — and supramaximal resection stands apart with striking survival separation.

The new RANO resection classes redefine IDH-mutant grade 2 gliomas: every cm³ of residual tumor reshapes prognosis. Supramaximal surgery isn’t just technique — it’s biology. @TheLancetOncol #radonc

@ElonMuskNews47 Yes

The EORTC GUCG-1414 study (@ZilliThomas et al., Eur Urol Oncol 2025) represents an important contribution—though with structural limitations—to the understanding of the clinical impact of different types of androgen deprivation therapy combined with radiotherapy in very high-risk or locally advanced prostate cancer. The following table provides a concise and pragmatic synthesis that may be useful in daily clinical practice.

Every ray that illuminates can also burn. Every instrument of healing can become a weapon. What saves, if used without measure, destroys. And yet, for more than a century, light has remained our ally. We have learned to modulate it, to measure it, to give it form. Sometimes it enters the body like an invisible blade; at other times, it moves around the tumor like a breath of energy. It is the same light that once burned in Grubbe’s hands — the same that made Edison’s bulb shine — and that now flows silently through the bunkers of radiotherapy, within the precise beams of the accelerators. There is no contradiction here, but a paradox: radiation kills, and precisely for that reason it can heal. As if life, in order to continue, had to learn to live with its own opposite. It is on this fragile, luminous frontier that medicine and physics meet. And in that meeting — between measure and abyss — hope still shines.

I think , if really a recurrence, this is a site in which Linac MRI would give something more. I would apply, considering this is a sort of reirradiation for anterior ano-rectal wall, a scheme of 30 Gy/5 Fr. one another day. If not HT right now, i'd add 6 months ADT in RADIOSA style.

69-yo fit man, 3 years after RALP and adjuvant RT (pT3b pN1, ISUP 5) now with PSA recurrence with PSMA PET showing lesion in corpus cavernosus last year and now confirmed as growing. MRI confirmed. Q1: biopsy or not Q2: treat with RT (fractionation?) or systemic only?

A few years ago, @rweichselbaum posed—ironically, but not entirely so—the question: what is the difference between radiotherapy and radiosurgery? In some ways, this review attempts to answer that very question. This table provides a synopsis of its contents. #radonc thegreenjournal.com/article/S0167-… #radonc

Grafico tratto da un articolo del The Economist. Gli Americani, per avere un accesso più rapido alle terapie con nuovi farmaci, le pagano da 2 a 5 volte in più rispetto alla media dei paesi OCSE. Questo è il risultato di un Sistema Sanitario affaristico, in cui non vige il principio di universalità. Speriamo in Italia questo non avvenga. I tempi grami in cui versa il #SSN non mi inducono all' ottimismo. @Cartabellotta

I appreciated a lot this editorial.The #EMBARK trial redefines management of high-risk biochemical recurrence in prostate cancer: enzalutamide + ADT improves MFS, but integration with PSMA-PET, salvage RT, and MDT remains key. A step forward, not the final answer. #radonc can give an important contribution in this setting also for patients inside the trial selection criteria.

✨ 🔥🔥New Editorial in @EUplatinum EMBARK puts ARPIs in the spotlight, but where does RT stand in high-risk BCR? 💡 Perspectives, open questions, insights on imaging, MDT & integration 🚀 #radoncGUcommunity #PCa sciencedirect.com/science/articl…

Very interesting in @RO_GreenJournal this month. Are we moving towards the end of ENI era in #HNSCC? The table in the paper highlights how ENI in HNSCC is currently at a delicate balance: the standard approach ensures excellent regional control, with minimal ENF rates, yet residual toxicity drives the pursuit of de-escalation strategies. The most promising perspectives rely on the integration of tumor biology, advanced imaging, and refined risk stratification, with the aim of maintaining clinical safety while minimizing side effects. #radonc #precisionmedicine thegreenjournal.com/article/S0167-…

Absolutely agree . " Let us reclaim the narrative. Let us lead with the values that radiation oncologists uphold every day: precision, safety, and empathy, with the goal of cure or relief. In doing so, we honor not only our science but the trust our patients place in it—and in us. " @IJROBP #radonc

@carlorovelli Why I Believe in God I don’t believe in God because I fear hell — but because, like Rovelli, I love goodness for its own sake. And yet, I believe that this pure love, that selfless kindness, has a deeper origin than brain chemistry or evolution: an origin we call God. I don’t believe in God to please Him — but because when I love, when I feel compassion, when I choose what is right despite the cost, I feel part of something greater. An ancient echo calls me by name. And I cannot ignore it. I don’t see God as a refuge or reward. I see God as relationship: the invisible thread that connects me to the faces of friends, to the eyes that suffer, to the mystery that surrounds and dwells within us. I don’t pray because I know, but because I don’t know. I don’t seek God to solve the mystery, but to dwell in it with gratitude. I believe that fairy tales are false only if they try to deny complexity — but authentic faith doesn’t erase doubt, it embraces and transforms it. I believe the world is not only what we can see. I believe that awe before the starry sky is not just aesthetic, but spiritual. That beauty is a doorway: to others, to the beyond. I don’t believe in a church that claims a monopoly on goodness — but in a community of seekers, wanderers, and pilgrims. People who fall, rise again, and still believe that love has meaning. Against all odds. I believe in God not because I’ve found all the answers, but because I cannot believe that meaning is limited to what can be measured. Because even in not knowing, I feel that Someone knows. And when I sit in silence — as Rovelli does — I don’t just hear the silence. I hear a call. I feel a Presence. And there, in the depths of that silence, God does not explain — God accompanies.

Spero che il #populismo non riesca anche ad infiltrarsi in modo dannoso in alcuni processi scientifici che potrebbero apportare all' umanità enormi benefici. Chissà se le evidenze vinceranno su certe eminenze

Ci vediamo a Palmi per la presentazione del libro di @ScaltritiLab. Un libro (che consiglio) scritto da un vero " insider" della ricerca in #Oncologia traslazionale.

A very interesting and enjoyable article to read on @NatRevClinOncol (doi.org/10.1038/s41571…) which takes stock of the complex mechanisms of interaction between the microbiota and radiotherapy #radonc. It may seem strange and counter-intuitive, but 1 Gy of radiotherapy targeting the small bowel could offer some benefits. Intestinal low-dose radiotherapy promotes the enrichment of beneficial bacteria in the gut and increases circulating cholesterol, α-tocopherol and distinct bile salts, thus mobilizing DCs towards mesenteric lymph nodes and tumour-draining lymph nodes, culminating in tumour infiltration by activated effector CD8+ T cells.