Suleyman Can Akerman

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy science.org/doi/10.1126/sc…

A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution science.org/doi/10.1126/sc…

Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathy alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers sciencedirect.com/science/articl…

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes science.org/doi/10.1126/sc…

Amyloid-β 42-carrying extracellular vesicles are associated with neurodegeneration and neuroinflammation in Alzheimer’s disease biorxiv.org/content/10.110…

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis cell.com/cell/fulltext/…

Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory science.org/doi/10.1126/sc…

Region-specific features of early glial activation and Aquaporin-4 dysregulation in conditional mouse models of TDP-43 proteinopathies biorxiv.org/content/10.648…

Targeted proteomics via NULISAseq identifies blood-detectable markers of disease progression in familial frontotemporal lobar degeneration alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Biology and therapeutic potential of extracellular vesicle targeting and uptake nature.com/articles/s4158…

Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia sciencedirect.com/science/articl…

The profiling of extracellular vesicle subtypes in Huntington’s disease brains identifies Alix as a novel marker of neuropathology link.springer.com/article/10.118…

Extracellular vesicles as a liquid biopsy for amyotrophic lateral sclerosis: a systematic review and meta-analysis medrxiv.org/content/10.648…

4R-tau isoform induction via TDP-43 in neurons in response to insulin: converging signaling pathways with implications for neurodegenerative disease link.springer.com/article/10.118…

The evolving landscape of Alzheimer’s disease therapy: From Aβ to tau #fig1" target="_blank" rel="nofollow noopener">cell.com/cell/fulltext/…

Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes biorxiv.org/content/10.648…

Detection of TDP-43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Engineered AAV Capsids with Enhanced Extracellular Vesicle Loading via Rational Design and Directed Evolution biorxiv.org/content/10.648…