Suleyman Can Akerman

Local Organization of Biological Membranes Modulates Tau–Lipid Interactions and Fibril formation pubs.acs.org/doi/full/10.10…

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification biorxiv.org/content/10.648…

Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation nature.com/articles/s4440…

Vascular burden attenuates the TDP-43-TMEM106B pathological relationship in neurodegenerative disease with and without Alzheimer disease neuropathological change academic.oup.com/jnen/advance-a…

MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer’s disease and Down syndrome link.springer.com/article/10.118…

Neuropathological analysis of an ALS patient carrying a SOD1 missense variant and a C9orf72 repeat expansion link.springer.com/article/10.100…

GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy nature.com/articles/s4146…

TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain biorxiv.org/content/10.648…

An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration nature.com/articles/s4159…

Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves motor function in tauopathy mice science.org/doi/10.1126/sc…

Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneity alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

RPL38 controls 60S ribosomal subunit homeostasis to regulate start-codon stringency and frame selection during C9ORF72 RAN translation biorxiv.org/content/10.648…

Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner pnas.org/doi/full/10.10…

Recapitulation of plaque formation, tau pathology, and neurodegeneration in a human 3D matrix model of Alzheimer’s disease cell.com/cell-reports-m…

A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer’s disease link.springer.com/article/10.100…

A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer’s disease link.springer.com/article/10.100…

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy science.org/doi/10.1126/sc…

A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution science.org/doi/10.1126/sc…

Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathy alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…