Carlos F. Nance

#LongCovid El coste humano de no reconocer el #COVID como una enfermedad de transmisión aérea. Se sigue incumpliendo normas de seguridad. Las mascarillas quirúrgicas, que se siguen usando, no están diseñadas para proteger contra virus de transmisión aérea. thetyee.ca/Analysis/2026/…

Every COVID-19 infection carries a risk of Long COVID - affecting the brain, heart, lungs, and immune system in ways that can last months or longer. Prevention still works. - Masking: Wear a high-quality mask (N95 or better) to reduce spread - Ventilation: Bring in fresh air and use HEPA filtration indoors - Distancing: Reduce crowding, use hybrid/remote options when possible - Testing: Test early and often - Vaccination: Helps protect against severe illness, especially with other measures #PublicHealth #COVIDIsNotOver #COVID #COVID19 #LongCOVID #LongCOVIDAwareness

El ##LongCOVID podría estar provocando cambios cerebrales similares a los del #Alzheimer Una investigación de NYU Langone Health podría explicar por qué algunos pacientes experimentan una niebla mental persistente y problemas de memoria mucho después de una infección por #COVID

From a study of 49 patients with post COVID-19 condition (80% female) and 48 healthy controls, "Patients with post COVID-19 condition exhibited significant deficits of attention, executive functions, phonemic and semantic fluency, verbal learning and episodic and visuospatial memory.. Thalamic volumes were significantly reduced in patients with post COVID-19 condition.. Fractal dimensionality analyses showed increased complexity in the occipital lobes and hippocampal fimbriae, and reduced complexity in the thalamus bilaterally in patients.. [In conclusion,] analyses revealed reduced thalamic volumes and reduced thalamic complexity that was associated with fatigue severity [among patients with post COVID-19 condition]." SARS-CoV-2 is a brain transformer. 'Association of structural brain changes with cognitive deficits and fatigue in patients with post COVID-19 condition' academic.oup.com/braincomms/adv…

#LongCovid El #COVID me dejó incapacitado a los 30 años, cuando era bombero/paramédico y estaba sano. Una sola infección me arrebató todo mi futuro. Seis años después, todavía no hay ningún tratamiento ni cura aprobados para el #COVIDPersistente.

#LongCovid Nuevo estudio: Hasta el 60 % del personal sanitario en Suiza podría padecer #COVIDPersistente 4 años después de la infección.

Persistent Viral Reservoirs in Post-COVID Patients: Current Evidence and Clinical Implications 🚨Viral persistence isn't fringe theory anymore! ➡️This INTERESTING Korean review article examines the hypothesis that SARS-CoV-2 persists in human tissues beyond acute infection, contributing to long COVID (PASC). Authors synthesize evidence in detail from studies showing viral RNA and proteins (especially spike) detectable in organs like lungs, heart, brain, gut, and kidneys, as well as in immune cells (e.g, monocytes, macrophages) and body fluids (stool, saliva, urine), sometimes up to 15 months post-infection. ➡️Their short Long COVID Overview: - Long COVID (PASC) features persistent or recurring symptoms (fatigue, brain fog, dyspnea, myalgia, cognitive issues) ≥4–12 weeks post-acute infection, lasting up to at least 24 months. - ~17% of cases show no recovery and ~18% remain partially symptomatic at 24 months. - Pathophysiology is heterogeneous and incompletely understood - Viral persistence is one leading hypothesis, ➡️ Found evidence of SARS-CoV-2 persistence: - Viral RNA and/or proteins (especially spike) detected in multiple organs/tissues post-acute phase: lungs (alveolar macrophages), heart (myocardial cells), brain (neural tissues), gut (intestinal epithelium), kidneys. - Persistence in immune cells: monocytes, macrophages, dendritic cells, T cells (via phagocytosis, restricted infection, or antigen retention). - Detection in body fluids: prolonged RNA in stool, saliva, urine (weeks to months post-onset). - Duration: signals observed weeks to months (some studies up to 15+ months) - Infectious virus rarely isolated post-acute phase. - Methods: RT-PCR, immunohistochemistry, in situ hybridization, electron microscopy but rarely confirms replication-competent virus, ➡️ Mechanisms of viral persistence and immune effects: - No classical latency (unlike herpesviruses). It involves incomplete clearance, abortive/restricted infection, antigen retention in long-lived cells (e.g, macrophages, microglia). - Immune evasion: interferon signalling inhibition, suppressed antigen presentation. - Persistent signals activate innate pathways (TLR3/7/8, RIG-I/MDA5), triggering NF-κB/IRF cascades → sustained cytokine production (IL-6, TNF-α), chronic inflammation, endothelial dysfunction. - Spike protein persistence may drive autoantibody formation, molecular mimicry, epitope spreading, and autoimmune-like responses, ➡️ Clinical implications and symptom links: - Persistent viral elements plausibly sustain multi-system inflammation, contributing to fatigue, brain fog, dyspnea, myalgia, cognitive dysfunction, cardiovascular/GI/renal issues. - Brain: neuroinflammation linked to headaches, mood/cognitive changes. - Gut/heart/kidney: associated with GI symptoms, myocardial inflammation, renal dysfunction. - Vascular: endothelial spike presence → microvascular abnormalities, chest pain, tachycardia. - Causal link to symptoms remains associative, not definitively proven, ➡️Risk factors: - Increased risk with age, sex, comorbidities (diabetes, obesity, immunosuppression), high acute viral load, lack of vaccination. - Immune features: impaired interferon responses, pre-existing autoreactivity, high ACE2/TMPRSS2 expression in tissues, ➡️Possible therapeutic approaches: - No approved disease modifying treatments, current care is symptomatic. - Investigational: extended antivirals (e.g., nirmatrelvir/ritonavir/Paxlovid up to 25 days in trials like RECOVER-VITAL), monoclonal antibodies. - Immunomodulatory: corticosteroids, JAK inhibitors, IL-6/TNF biologics to target inflammation. - Emerging: mesenchymal stem cells (MSC) for repair and anti-inflammation (ongoing trials, e.g, NCT04992247). - Emphasis on personalized, multi-modal strategies based on symptom profiles, ➡️Conclusions and limitations: - Strong evidence of persistent RNA/protein signals in tissues/cells, linked to inflammation and long COVID heterogeneity. - Distinguishing non-replicating remnants from active infection remains challenging, causation unproven. - Future needs: biomarkers, longitudinal studies, advanced assays (single-cell transcriptomics, negative-strand RNA), targeted trials. ‼️Persistent SARS-CoV-2 RNA and proteins are clearly detectable long after acute infection and plausibly drive chronic inflammation underlying long COVID, yet they do not prove ongoing replication or definitive causation, leaving effective eradication therapies out of reach and patients without validated cures. ‼️Reinfections receive essentially zero attention in this review, underscoring that viral persistence theories for long COVID remain overwhelmingly ffocused around unresolved remnants from the first infection, with any potential role of repeat infections left virtually unexplored here! ‼️So, in a field still lacking consensus on long COVID's root causes, this review critically elevates viral persistence from speculative hypothesis to a biologically plausible, and potentially treatable, core driver, yet its ultimate proof and therapeutic translation remain frustratingly elusive, leaving millions without targeted relief. #AvoidSars2 #AvoidReinfections mdpi.com/2673-8112/6/3/…

#LongCocid El aviso de Antonio Alarcó sobre la "bomba biológica" de la #CovidPersistente: 2,4 millones de españoles afectados diariodeavisos.elespanol.com/2026/03/antoni…

Long Covid affects people of all ages and includes a myriad of post-acute and long-term adverse health effects caused by the infection. ⁠ ⁠ A 2024 #SciencePerspective highlighted the efforts made to understand this public health concern, what is known about the condition, and its wide-reaching effects on the risk of developing other chronic diseases. ⁠ Despite increasing knowledge of the mechanisms, epidemiology, and prevention, several challenges remain. First, the care needs of people experiencing Long Covid are consistently not met, and patients are often met with skepticism and dismissal of symptoms. Second, the lack of consensus on terms, definitions, and clinical trial endpoints for Long Covid, as well as the lack of animal models that can capture the breadth of Long Covid phenotype, are slowing progress and hampering the discovery of drugs that could improve patient health.⁠ ⁠ Addressing these challenges would not only provide insights into Long Covid but also other infection-associated chronic illnesses that have underappreciated long-term health impacts like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).⁠ ⁠ Learn more on #LongCovidAwarenessDay: scim.ag/3DCyV2Q

Today is #LongCovidAwarenessDay Long Covid changed my life beyond recognition. I got ill. I never recovered. Lost my job. Became housebound. I rely on others to do things for me. I lie on my bed most of the day. Watch the Guardian's short film about my life with #LongCovid 👇

El #LongCOVID deja a miles de residentes del condado de Los Ángeles enfermos, arruinados e ignorados. Mientras otros superan la #Pandemia, miles de personas con #COVIDPersistente siguen padeciendo enfermedades crónicas y discapacidades. latimes.com/science/story/…

El autor de esta canción, tras años conviviendo con el #LongCOVID, decidió volcar todo su cansancio, la incertidumbre y la esperanza en estos versos. Esta canción es mucho más que música; es un pedazo de su vida y su lucha... youtube.com/watch?v=pigNNQ…

You know what frightens me... even mild SARS-CoV-2 infections can trigger direct myocardial injury, lasting endothelial damage, persistent inflammation, and a prothrombotic state. This raises the long-term risk of heart attack, heart failure, stroke, arrhythmias, and clots—often by around 1.5–2× (and higher in severe cases) for years afterward. Each reinfection can compound this cumulative cardiovascular burden, heightening Long COVID risks and making every exposure a potential step closer to accelerated or lifelong heart disease vulnerability, though vaccination can lower the risks but does not erase them! #AvoidSars2 #AvoidReinfections

An immunocompromised teen was fully-vaccinated for measles, & she still tested positive for measles, pneumonia, COVID, & Haemophilus influenzae. To recap: Covid is quietly causing immunodeficiency, & our society completely ignores this fact. This is becoming more & more common.

🔴 #ÚLTIMAHORA | El Tribunal de Marsella reconoce un "vínculo directo" entre el cáncer de mama de una enfermera y sus 25 años de turnos de noche. La sentencia dictamina que la patología es "imputable al servicio" y otorga el derecho a una renta vitalicia.

#LongCovid Sin tratamiento específico, carecen de una protección adecuada por parte de las empresas y autoridades sanitarias, y que, en muchos casos, se les presiona y discrimina en sus puestos de trabajo.  #twitter?utm_source=Twitter&utm_medium=social&utm_campaign=desktop" target="_blank" rel="nofollow noopener">20minutos.es/nacional/hasta…

"The COVID-19 pandemic at 6 years: Mass death, debilitation and media silence" 🔹 30+ million deaths worldwide 🔹 400+ million people living with Long COVID 🔹 One of the most catastrophic events in modern history 🔹 The pandemic is not over wsws.org/en/articles/20…

#LonCovid La pandemia ha matado a más de 30 millones de personas y dejado a más de 400 millones con #COVIDPersistente. Es uno de los eventos más catastróficos de la historia y aún no terminó. La pandemia de #COVID tras 6 años: Muerte masiva, debilitamiento y silencio mediático

#LongCovid Una duda que me ronda. La posibilidad de que el SARS-CoV-2 podría actuar como un "oncovirus" al alterar proteínas supresoras de tumores (como p53 y pRB) se está teniendo en cuenta en ese y otros estudios?

@alfwarrior Una duda que me ronda. La posibilidad de que el SARS-CoV-2 podría actuar como un "oncovirus" al alterar proteínas supresoras de tumores (como p53 y pRB) se está teniendo en cuenta en ese y otros estudios?

🧵 Está circulando un paper que afirma que las vacunas de ARNm provocan reprogramación génica persistente. Ei supuesto estudio afirma: que las vacunas de ARNm contra COVID-19 no solo inducen respuesta inmune transitoria, sino que... 1/25