Charles Winterhalter

Still time left to apply and join my team on a fully funded PhD project investigating dynamics of the bacterial DNA damage response in live cells using microscopy & genomics

Excited to share with you the story that enabled me to start my own lab: what happens when the bacterial DNA replication machinery encounters single-strand discontinuities on template DNA? What is required for DNA break repair and replication restart? biorxiv.org/content/10.110…

Come and do a PhD with me and @DrPaulJamesUK to find some new exciting enzymes! #glycotime findaphd.com/phds/project/n…

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

Navigating through academia as an ECR can be challenging. @CKYLau and @CorreiaMeloC will tell us more about their experience of becoming group leaders and how to achieve this on 12th Feb @BiochemSoc. Free registration at attendee.gotowebinar.com/register/61033…

Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date). @JohnInnesCentre @DurhamU34989 @MCB_UJ

2 weeks to go! Apply for the 2 posts by Nov 25th - pls RT!

@AKTooke @foster_lab @steverenshaw @becky31290 @JosiePyrah @MM_Sheffield @unmc Well done! Hard work always pays off!

Happy to share this story from my PhD @foster_lab & @steverenshaw - with @becky31290 in Ken Bayles’ lab & @JosiePyrah - we show that oxacillin & tetracycline display synergy against S. aureus biofilms & during infection in zebrafish! @MM_Sheffield @unmc link.springer.com/article/10.100…

Fully-funded @DiMeN_DTP PhD opportunity available in my lab to investigate novel DNA damage repair processes using next generation sequencing and microscopy techniques (co-supervised by @acdarby & @MicKasia). Please RT and contact me if interested. findaphd.com/phds/project/m…

We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to methicillin requires S. aureus to utilise an alternative mode of cell division to ensure its survival! @Sheffield_AFM @Olulana4 doi.org/10.1126/scienc…

As well as improving our daily lives, university research contributes £54 BILLION to the UK economy and supports 121k jobs across the UK📈 If we want to be a country fit for the future, the government must make research funding more sustainable👇 loom.ly/T-7pw68

DTP PhD studentship available in our lab. Start: Oct 2025. Apply: now-24th Nov 2024 Taming the Viral Wolf: Cracking the Code of Gene Transfer Agents in Bacteria. Please RT. Thank you!!! shorturl.at/sR2px

If you haven't already, check out the Hachiman phage defence system characterised by the @doudna_lab @CellCellPress. Inspiring work and scary 'phantom' cells (perfect for Halloween!) 👏 cell.com/cell/fulltext/…

Please RT. 1x postdoc and 1xPhD position available in our group to study the role of NLR-like proteins in cellular development and antibiotic production in Streptomyces. Postdoc: shorturl.at/f8NTN PhD position: shorturl.at/qCFmN Email me for more information.

Super nice Single Molecule Bacteriology meeting in the Cotswolds. Thanks to the organisers, looking forward to new collaborations and see you at the next event!

Looking forward to day 2 at the UK DNA Replication Meeting for more amazing talks! Come and find me this evening at Poster 4 to hear all about replisome arrest and replication restart from nicks @BiochemSoc #BioChemEvent

Registration for the Single Molecule Bacteriology III conference is open, I am honoured to be invited speaker and looking forward to meet you all there!

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_raphael, @TripathiVeenu, and many terrific collaborators including @FrogWalterLab, @CejkaLab, @weiwsmiling. See science.org/doi/epdf/10.11…

A rewarding collaboration revealing an entirely novel inhibitor pocket in DNA gyrase. Inhibition mechanism determined via beautiful biochemistry experiments by @leela_bg - well done Leela! Thanks to @yushuv @AstburyCentre for the final EM data collection 👍