Dapeng Chen

The S. aureus V8 serine protease is a master manipulator of the immune response. But what does it target? Using a high-efficiency N-Terminomic approach, researchers capture ~320 biologically relevant V8 targets in the human lung proteome. #IAIJournal: asm.social/2R9

Sepsis is a serious condition where the body’s response to an infection becomes out of control and starts to damage its own organs. A Seminar explores the complexity of the condition, and discusses current challenges and future developments in care: spkl.io/6015ALnw1

Presence of neutrophil extracellular traps (NETs) in different types of human urinary tract infections (UTI). A pilot study ▶️ Cystitis is the most common UTI in humans. This infection can ascend the urinary tract, spreading to the renal pelvis and potentially causing serious conditions such as pyelonephritis or urosepsis. ▶️ Human UTIs are primarily of bacterial origin, with E. coli being the most common urogenital pathogen. ▶️ A key defense mechanism of the innate immune system involves the formation of NETs that can trap and eliminate microbial agents. ▶️ Activated polymorphonuclear neutrophils (PMNs) release NETs, composed of a reticular DNA core, along w/nuclear histones, granular peptides, & enzymes. ▶️ Elevated levels of NETs, ​​exDNA, and related proteins, such as LL37 and MPO, were detected in urine samples from patients with UTIs & were associated w/leukocyturia. ▶️ Drugs such as furosemide, which affect the kidney's electrolyte balance & reduce NET formation, can exacerbate pyelonephritis. ▶️ The formation of the NETosis phenomenon is linked to the exacerbation of UTIs. ▶️ The presence of NETs in human urine confirms their role in the pathogenesis of urinary tract infections (UTIs). ▶️ Understanding these complex mechanisms could contribute to the development of targeted therapeutic strategies for patients with UTIs, although the polymicrobial nature of many complicated or recurrent UTIs poses a challenge. doi.org/10.3389/fimmu.… @HealthyFellow @tatiann69922625 Live-cell fluorescence microscopic (LCFM) analysis of human urine samples for the detection of bacterial colonization, leukocyturia, cellular activity and NET release

Pedal to the metal: iron regulation of Aspergillus fumigatus protease production @atscommunity 🔓 Open Access 🔗 tinyurl.com/yc6hjdpa

More and more papers showing neutrophils are diverse and can very closely manipulate adaptive immunity here they show neutrophils stimulating a B cell mediated autoimmune disease science.org/doi/10.1126/sc…

Nature research paper: Natural maternal immunity protects neonates from Escherichia coli sepsis go.nature.com/4rtl1TE

Catheter-Associated Urinary Tract Infections Surveillance and Prevention doi.org/10.1016/j.idc.…

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment nature.com/articles/s4146…

Glutathione is critical for NK cell-mediated immunity dlvr.it/TR8vPN

Now in @CellCellPress: We profiled cerebrospinal fluid proteomes from 5,000 neurology patients by mass spectrometry — mapping protein changes across stroke, brain cancer, infections & autoimmune diseases, revealing shared and disease-specific signatures. sciencedirect.com/science/articl…

An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning go.nature.com/4cCjDKq

Leukocytic ADAM10 and ADAM17 and their release on exosomes modulate the local and systemic response upon bacterial and viral pneumonia and should be evaluated for diagnostic, prognostic and therapeutic options in future translational and clinical studies bit.ly/4pQSGXI

In the latest issue! Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment dlvr.it/TR752Q

Immune dysfunction in Alzheimer disease | Nature Reviews Neuroscience nature.com/articles/s4158…

Who said there’re no validated outcome biomarkers in IPF? Analysis of 1280 (‼️) IPF patients confirms that ⬆️⬆️ baseline plasma MMP7 & CCL18 are predictive of ⬆️⬆️ mortality. 👏🏼👏🏼 Drs Randall, Bauer & team for great use of data from negative trial publications.ersnet.org/content/erjor/…

In the largest IPF cohort to date, MMP-7 and CCL18 are recognised as prognostic biomarkers for disease progression and mortality. Their combination and longitudinal CCL18 changes may enhance risk stratification and support treatment efficacy, respectively. bit.ly/4oqmz05

Characterisation of the eosinophilic endotype of bronchiectasis We use a novel method of quantifying eosinophil granule proteins in sputum: Eosinophilic inflammation is present in bronchiectasis but poorly associated with blood eosinophils @EMBARCnetwork thorax.bmj.com/content/early/…

European Respiratory Journal: This study emphasises the importance of including both airway (e.g. nasal) and blood in COPD studies. These minimally invasive nasal swabs assessing the upper airway can inform the pathobiology of COPD and serve as biomarkers. bit.ly/47zzre3

Community-Acquired Pneumonia: A Review | Infectious Diseases | JAMA (jamanetwork.com/journals/jama/…)

Microbes Meet Host: The Next Frontier in Sepsis Classification @atscommunity 🔓 Open Access 🔗 tinyurl.com/bdes2e5s