KUMedChem
114 posts

KUMedChem
@ChemKu
Department of Medicinal Chemistry, University of Kansas - Lawrence






I am very proud to share our most recent work, now accepted in @angew_chem. Good work @mannpharm, @pawandhote1 et al. Photochemical Decarbonylation of Oxetanone and Azetidinone: Spectroscopy, Computational Models, and Synthetic Applications onlinelibrary.wiley.com/doi/10.1002/an…

Late-stage skeletal editing of peptide −SS− bonds through bis-dehydroalanine intermediates provides ready access to chemically unique −CC− carbocycles with enhanced biopharmaceutical properties go.acs.org/2EC NEW #ASAP by Steven Bloom & Samuel Gary @ChemKu

It was an honor to give this year's Smissman Memorial Lecture and I owe a big thank you to the KU Medicinal Chemistry Department for hosting me!













Spirocyclic azetidine-lactones in a 7-step process with two key photochemical reactions: aza-Yang cyclization to make azetidinols and Buchner insertion of carbene into an aromatic ring to make lactone and cycloheptatriene. In #JOC from @djavko et al. pubs.acs.org/doi/10.1021/ac…


