Christopher

@arristizaball @WABetaInfo @grok Lets users add new members in their group chats from the mention picker.

@WABetaInfo @grok o que há de novo?

WhatsApp beta for Android 2.26.14.8 update is available to some beta testers.

With the rise of new tools in molecular biology, it’s becoming clear that viruses and other pathogens can remain in the body or otherwise affect its workings for a surprisingly long time time.com/article/2026/0…

University of Queensland scientists found COVID-19 harms blood vessels indirectly as infected airway cells release IL-1β and TNF, which trigger inflammation, cell death, and clotting risk in nearby vessels. biorxiv.org/content/10.648…

"COVID-19 patients show structural and functional changes in multiple cortical and subcortical regions compared to healthy subjects.. alterations were predominantly in frontal regions, temporal regions, parietal regions, limbic system, and subcortical nuclei. The microstructural and functional alterations in these regions may underlie impairment of a number of neurocognitive functions.. For acute COVID-19, whole-brain studies indicate lower GMV and functional activity (lower functional connectivity or ALFF), disruption of white matter fiber structures (lower FA or tract length), and increased tissue diffusivity (higher apparent diffusion coefficient or MD).. brain changes in long COVID-19 may be symptom-dependent, involving multiple neuropathological mechanisms, and do not present a uniform, stable global pattern.." Alterations in the brain cause alterations in personality. 'Widespread structural and functional brain alterations in COVID-19: a systematic review of MRI studies' academic.oup.com/cercor/article…

My new research is out "Overview and Pathophysiology of Long Covid" I provide an updated overview of key concepts, terminology and epidemiology of LC. I also offer an analysis of key mechanisms of pathology and multi-organ involvement in #LongCovid mdpi.com/2673-8112/6/3/…

Up to 60% of health care workers may have long COVID 4 years after infection. "Four years after infection with the wild-type SARS-CoV-2 strain, up to 60% of health care workers (HCWs) in Switzerland still reported at least one COVID-19 symptom" cidrap.umn.edu/covid-19/60-he…

BREAKING: Scientists have engineered a virus that invades and destroys glioblastoma one of the deadliest brain cancers while turning the immune system into a relentless tumor-killing force. This could be a historic shift in cancer treatment. 🧬🚨

New study: Up to 60% of health care workers in Switzerland may have long COVID 4 years after infection. Of participants with complete data, those with an initially high number of symptoms tended to have higher symptom scores in the last survey. Read more: ow.ly/k5Nq50Yx6kc

Persistent Viral Reservoirs in Post-COVID Patients: Current Evidence and Clinical Implications 🚨Viral persistence isn't fringe theory anymore! ➡️This INTERESTING Korean review article examines the hypothesis that SARS-CoV-2 persists in human tissues beyond acute infection, contributing to long COVID (PASC). Authors synthesize evidence in detail from studies showing viral RNA and proteins (especially spike) detectable in organs like lungs, heart, brain, gut, and kidneys, as well as in immune cells (e.g, monocytes, macrophages) and body fluids (stool, saliva, urine), sometimes up to 15 months post-infection. ➡️Their short Long COVID Overview: - Long COVID (PASC) features persistent or recurring symptoms (fatigue, brain fog, dyspnea, myalgia, cognitive issues) ≥4–12 weeks post-acute infection, lasting up to at least 24 months. - ~17% of cases show no recovery and ~18% remain partially symptomatic at 24 months. - Pathophysiology is heterogeneous and incompletely understood - Viral persistence is one leading hypothesis, ➡️ Found evidence of SARS-CoV-2 persistence: - Viral RNA and/or proteins (especially spike) detected in multiple organs/tissues post-acute phase: lungs (alveolar macrophages), heart (myocardial cells), brain (neural tissues), gut (intestinal epithelium), kidneys. - Persistence in immune cells: monocytes, macrophages, dendritic cells, T cells (via phagocytosis, restricted infection, or antigen retention). - Detection in body fluids: prolonged RNA in stool, saliva, urine (weeks to months post-onset). - Duration: signals observed weeks to months (some studies up to 15+ months) - Infectious virus rarely isolated post-acute phase. - Methods: RT-PCR, immunohistochemistry, in situ hybridization, electron microscopy but rarely confirms replication-competent virus, ➡️ Mechanisms of viral persistence and immune effects: - No classical latency (unlike herpesviruses). It involves incomplete clearance, abortive/restricted infection, antigen retention in long-lived cells (e.g, macrophages, microglia). - Immune evasion: interferon signalling inhibition, suppressed antigen presentation. - Persistent signals activate innate pathways (TLR3/7/8, RIG-I/MDA5), triggering NF-κB/IRF cascades → sustained cytokine production (IL-6, TNF-α), chronic inflammation, endothelial dysfunction. - Spike protein persistence may drive autoantibody formation, molecular mimicry, epitope spreading, and autoimmune-like responses, ➡️ Clinical implications and symptom links: - Persistent viral elements plausibly sustain multi-system inflammation, contributing to fatigue, brain fog, dyspnea, myalgia, cognitive dysfunction, cardiovascular/GI/renal issues. - Brain: neuroinflammation linked to headaches, mood/cognitive changes. - Gut/heart/kidney: associated with GI symptoms, myocardial inflammation, renal dysfunction. - Vascular: endothelial spike presence → microvascular abnormalities, chest pain, tachycardia. - Causal link to symptoms remains associative, not definitively proven, ➡️Risk factors: - Increased risk with age, sex, comorbidities (diabetes, obesity, immunosuppression), high acute viral load, lack of vaccination. - Immune features: impaired interferon responses, pre-existing autoreactivity, high ACE2/TMPRSS2 expression in tissues, ➡️Possible therapeutic approaches: - No approved disease modifying treatments, current care is symptomatic. - Investigational: extended antivirals (e.g., nirmatrelvir/ritonavir/Paxlovid up to 25 days in trials like RECOVER-VITAL), monoclonal antibodies. - Immunomodulatory: corticosteroids, JAK inhibitors, IL-6/TNF biologics to target inflammation. - Emerging: mesenchymal stem cells (MSC) for repair and anti-inflammation (ongoing trials, e.g, NCT04992247). - Emphasis on personalized, multi-modal strategies based on symptom profiles, ➡️Conclusions and limitations: - Strong evidence of persistent RNA/protein signals in tissues/cells, linked to inflammation and long COVID heterogeneity. - Distinguishing non-replicating remnants from active infection remains challenging, causation unproven. - Future needs: biomarkers, longitudinal studies, advanced assays (single-cell transcriptomics, negative-strand RNA), targeted trials. ‼️Persistent SARS-CoV-2 RNA and proteins are clearly detectable long after acute infection and plausibly drive chronic inflammation underlying long COVID, yet they do not prove ongoing replication or definitive causation, leaving effective eradication therapies out of reach and patients without validated cures. ‼️Reinfections receive essentially zero attention in this review, underscoring that viral persistence theories for long COVID remain overwhelmingly ffocused around unresolved remnants from the first infection, with any potential role of repeat infections left virtually unexplored here! ‼️So, in a field still lacking consensus on long COVID's root causes, this review critically elevates viral persistence from speculative hypothesis to a biologically plausible, and potentially treatable, core driver, yet its ultimate proof and therapeutic translation remain frustratingly elusive, leaving millions without targeted relief. #AvoidSars2 #AvoidReinfections mdpi.com/2673-8112/6/3/…

Long Covid affects people of all ages and includes a myriad of post-acute and long-term adverse health effects caused by the infection. ⁠ ⁠ A 2024 #SciencePerspective highlighted the efforts made to understand this public health concern, what is known about the condition, and its wide-reaching effects on the risk of developing other chronic diseases. ⁠ Despite increasing knowledge of the mechanisms, epidemiology, and prevention, several challenges remain. First, the care needs of people experiencing Long Covid are consistently not met, and patients are often met with skepticism and dismissal of symptoms. Second, the lack of consensus on terms, definitions, and clinical trial endpoints for Long Covid, as well as the lack of animal models that can capture the breadth of Long Covid phenotype, are slowing progress and hampering the discovery of drugs that could improve patient health.⁠ ⁠ Addressing these challenges would not only provide insights into Long Covid but also other infection-associated chronic illnesses that have underappreciated long-term health impacts like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).⁠ ⁠ Learn more on #LongCovidAwarenessDay: scim.ag/3DCyV2Q

@NenkMonica Video yg sama dari instagram: instagram.com/reel/DV0pUN0zD…

Sebuah insiden tak terduga terjadi di tengah laut ketika kapal ferry pengangkut kendaraan dilaporkan mengalami oleng, mengakibatkan beberapa unit mobil jatuh ke laut.

@NenkMonica Video yg sama dari facebook: facebook.com/share/r/1Bzti5…

@NenkMonica Video yg sama dari tik tok: @the.worldai/video/7603250211149991175?is_from_webapp=1&sender_device=pc" target="_blank" rel="nofollow noopener">tiktok.com/@the.worldai/v…

Now online! Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air dlvr.it/TRbDqm

Study: "We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested" Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies bioRxiv biorxiv.org/content/10.648…

From a recent governmental report on the healthy life expectancy of people in the UK, "in 2022 to 2024, males could expect to live an average of 60.3 years of healthy life and females an average of 60.9 years of healthy life. This compares with 62.5 for males and 63.4 for females in the previous period from 2019 to 2021.. This means that the healthy life expectancy of both males and females has fallen to their lowest levels since this kind of reporting began in 2011 to 2013.. This should be a deeply alarming report and what is perhaps even more alarming is how little coverage there has been of the report in the media.. The life expectancy levels consistently rose during the 20th century and into the first decade of the 21st century. However, the long-held assumptions that children would both be better off than their parents and live longer can now no longer be taken for granted.. [Rather] life expectancy is now going down, which is surely a sign of something going very wrong with our society." Spreading SARS-CoV-2 is very wrong. 'Report details declining life expectancy in the UK' northeastbylines.co.uk/news/health/re…

COVID-19 Linked Catatonia Syndrome Raises New Global Concern

What is persistent #SARS-CoV-2 Spike doing in gut tissue in situ? In our new preprint, we used spatial transcriptomics, RNAscope, GeoMx DSP, and multiplex IF to investigate biopsies from #LongCOVID The immune dysfunction happen on spike + regions of LC. biorxiv.org/content/10.648…

Source: abcnews.com/amp/Health/doc…

One of the most underappreciated aspects of viral infections is the long-term and severe consequences they can cause. Polio - lifelong paralysis HPV - cancer Hepatitis B/C - liver cancer Measles - immune amnesia COVID19 - long COVID Preventing infection matters.