Losada Lab

(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading? We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv biorxiv.org/content/10.110…

New article from the lab: cell.com/cell-reports/f… A brief, 6-tweet summary follows (1/6)

Last two days to apply and join the lab as postdoc fellow! #singlecell #3Dgenome #enhancer #plasticity #glioblastoma #cancerneuroscience

📢 2-year postdoc position!! Join us @Remeseiro_Lab to study #3DGenomics & #CellularPlasticity in #Glioblastoma #CancerNeuroscience. If you have background in #singlecell #omics and/or #bioinformatics, you're a good match to our team. Apply now 👇👇 Please RT RT RT 🤗

Tomorrow and invited by Ana Losada, @ChromDyn, Oscar Martinez will be at #CNIOStopCancer to speak about multi-omic approach to decipher the molecular mechanisms associated to #EwingSarcoma metastasis using a spontaneous metastasis mouse model. 👏Looking forward to it!

We are hiring!!!! 📢 We offer a 4-year FPI fellowship to work on Cohesin and 3D genome organization at @CNIOStopCancer. Please send your CV and a motivation letter to alosada@cnio.es

How is DNA packaged inside cells? The third dimension of the genome may harbor new cancer treatments. #CFM_Genome

We have been thinking a lot about NIPBL and cohesin lately…🤔

@CNIOStopCancer @KP_twitt_llo @CortesLab @nussenza @CaixaResearchCA Last day for abstract submission!📝

📢CNIO-CaixaResearch Frontiers Meeting 22-23 May 2023 👉Genome Organisation and stability Don't miss‼️ ⏳⏰Abstract Dedline April 20 Subscription Deadline May 8 Organisers: @KP_twitt_llo @CortesLab @ChromDyn @nussenza @CaixaResearchCA ▶ bit.ly/3JhDqjc

👉Third session #CFM_Genome about genome dynamic and stability. 👥With: @davegilbert19, from @SanDiegoBiomed and @marieprioleau from @IJMonod. 📋Inscriptions: bit.ly/3JhDqjc

Congrats to everyone involved👏 @dacil_ag, @Cuadrado4Ana, @DanielGLL_ and Miriam Rodriguez! @CNIOStopCancer

Finally out in @NatureComms!🥳 Is NIPBL required for cohesin loading in mammalian cells? Why do STAG1 and STAG2 cohesin complexes respond to NIPBL KD in opposite ways? Satisfy your curiosity in nature.com/articles/s4146…

The website of the Cohesinet MSCA Doctoral Network is now ready !!! Check out it for more info about our consortium and 12 PhD positions available to study cohesin biology and related diseases. Do not miss this opportunity. Deadline is on 1st of April. cohesinet.eu

@LabLegube Congratulations, well deserved!!

Thanks a lot to the FRM for awarding me the Raymond Rosen cancer prize, it's an honor. Kudos to all the scientists in my group, this prize is theirs!

(6/6) Great work led by Dácil Alonso Gil @dacil_ag with major contributions from Ana Cuadrado @Cuadrado4Ana, Daniel Giménez Llorente @DanielGLL_ and Miriam Rodríguez Corsino.

(5/6) We propose a new model in which cohesin does not need NIPBL for chromatin association but it does for loop extrusion. While cohesin-STAG1 binds at CTCF sites and becomes stabilized rapidly, cohesin-STAG2 bind elsewhere and require NIPBL in order to reach CTCF positions.

(1/6) NIPBL is required to fuel loop extrusion by cohesin. Is it also required for cohesin loading? We explore this question in a new preprint from the Losada Lab at @CNIOStopCancer posted in BioRxiv biorxiv.org/content/10.110…

🧬Check out our latest contribution to current understanding of cohesin dynamics. A joint effort from past and current group members! @CNIOStopCancer #Sec2" target="_blank" rel="nofollow noopener">…eneticsandchromatin.biomedcentral.com/articles/10.11…