Circulation

Secondary Prevention After Coronary Artery Bypass Graft Surgery: 2026 Update ahajrnls.org/3R5YkZ4

The GPRASP1-Parkin-ASNS axis links endothelial proteostasis to metabolic dysfunction and represents a potential therapeutic target in PH-HFpEF @Ybo_Wang ahajrnls.org/4u6PVTI

#OriginalResearch: defined the mechanism of CD40-TRAF2/3/5 - mediated efferocytosis in MI, providing insight into potential therapeutic targets to prevent cardiac ischemic injury. ahajrnls.org/4wv4WR6

@f2harrell @drjasondungu @mshunshin @DrJHoward @rajkumar_chris @henselig @MikeFoley89 @DrPeterOKane @ShaynaChotai @pajhaworth

ORBITA-FIRE suggests universal Ischemia-based thresholds for FFR and non-hyperemic pressure ratio should be interpreted with caution: Integrating symptom-linked physiology may refine PCI selection and improve symptomatic response.ahajrnls.org/3R6AzQD

#OriginalResearch identifies dolichoectasia and intracranial arterial widening as vascular phenotypes associated with cerebral small vessel disease ahajrnls.org/42r0Prr

#ICYMI: Exercise Deficits and HFpEF Predisposition @Landsteiner_I @MGHHeartHealth @GLewisCardiol @WendyPost9 @DrLekkiWood @Raj_MalhotraMD @KAmancherla @Perrycardium @laurapco @CampainJoseph @mikemi_md

#ICYMI: MR-proADM in ATTR-CM. @dr_pavia @peiro_belen

@AkihikoNogami @ecg_dr

Daily home-based stellate ganglion phototherapy reduced ATP/ICD shock burden from 3.9 to 0.0 events/month (P<0.01) in 28 patients with refractory VT — no serious adverse events. A novel outpatient neuromodulation strategy ahajrnls.org/3PiETvA

Age-related vascular changes contribute to disease. What drives vascular aging and how can these insights lead to new therapies? @AgingPitt ahajrnls.org/4d4CRbC

@Dr_Pavia @jpocardio

Intermediate effect variants (IEVs) in HCM genes are routinely misclassified as variants of uncertain significance, yet carry odds ratios of 5-15 and are found in 6% of HCM cases vs. 1% of controls. Proposed framework on how to incorporate into practice. ahajrnls.org/4u7XyJN

#ICYMI: TRIM28 inhibits I/R-induced myocardial ferroptosis

#ICYMI: YAP induces metabolic remodeling for Heart Repair @lin_liu__, @jmartinlab, @BCM_CVRI, @BCMHouston, @Texas_Heart @SirScienceAlot

#ICYMI: Long-Term Risk of Stroke After TIA or Minor Stroke @FaizanK91 @HotchkissBrain @UCalgaryMed @mihill68 @VYogendrakumar @draravindganesh @SimonFaHo @shanfernands @khanevski @rondalun1

@drashwinpillai @KennethEllenbo1

#ECGChallenge An 83y woman with non-ischemic HFrEF and a known LBBB undergoes an ECG at a routine visit ahajrnls.org/3QHQZ1M

#ICYMI: CKM syndrome stages, echo findings, and HF risk @matslassen @mvaduganathan @torbiering