Ron Cox

@Norma5387953815 1353

99.9% will fail..!! Tell me the number that is bigger than this..??

This girl thought her parents hadn't come to see her and this is how she reacted when she saw that they were there

When you think Sunday is peaceful… a deer just demolished a living room, broke a TV, and made a dramatic escape through a window. Nature’s wild side strikes again! #DeerGoneWild #AnimalMischief

@elonmusknews30 👍

Van Jones Gets Emotional After a Newly Discovered DM from Charlie Kirk “After he was murdered, my team called and said he was trying to reach you … This guy is reaching out to his mortal enemy saying, we need to be gentlemen and sit down together … I've sat on it long enough.”

My kids asked me what games I used to play on my IPad as a kid. I told them I used to speak into a fan to sound like a robot.

'Universal cancer vaccine' trains the immune system to kill any tumor | Bronwyn Thompson, New Atlas Following on from their breakthrough human trial that successfully reprogrammed the immune system to overpower glioblastoma, an aggressive brain tumor, the same scientists have now further developed the mRNA vaccine to fight not one but any cancer. It has the potential to do away with chemotherapy, surgery and radiation treatment. University of Florida (UF) scientists have developed an experimental vaccine that dramatically boosts the immune system’s ability to fight tumors – even without targeting a specific cancer type. This "general purpose" mRNA jab works in a similar way to a Covid-19 vaccine but with a different target; it instructs the body's immune cells to rally and hit any kind of tumor in the same way they would attack a viral spike protein. “This paper describes a very unexpected and exciting observation: that even a vaccine not specific to any particular tumor or virus – so long as it is an mRNA vaccine – could lead to tumor-specific effects,” said Elias Sayour, a pediatric oncologist and principal investigator at the RNA Engineering Laboratory at UF. “This finding is a proof of concept that these vaccines potentially could be commercialized as universal cancer vaccines to sensitize the immune system against a patient’s individual tumor." Sayour has spent a decade working to harness the power of mRNA science in order to effectively treat cancer. The success with the glioblastoma study led to broadening the treatment's scope, not targeting one kind of tumor but instead focusing on giving the body's immune system the tools to fight any kind of cancer cell. It's part of a growing body of evidence that suggests mRNA vaccines might be a serious weapon in fighting the disease. While the formulation isn't unlike the Covid-19 vaccine, which uses lipid nanoparticles to deliver the genetic instructions to the body, it is still somewhat different. Instead of the drug encoding a virus protein, it sends a message to the immune system to rally the troops. It essentially tells the body to produce certain proteins that stimulate the immune system – including a protein within cancer cells known as PD-L1 (Programmed Death-Ligand 1), which makes tumors become more visible to immune cells. The researchers found a way to induce PD-L1 expression inside tumors using a generalized mRNA vaccine, essentially tricking the cancer cell into exposing itself, so immunotherapy can be more effective. In this study on mice with melanoma, the vaccine was able to clear existing tumors that had proven drug-resistant. In other cancer models, including brain, skin and bone, the drug was even able to wipe out tumors without the assistance of any other treatment. This approach is a little unorthodox in a field moving increasingly more towards personalized medicine with a precise target in the crosshairs. Previous research has focused more on homing in on a target or tailoring a vaccine specific to a patient's own cancer profile. "This study suggests a third emerging paradigm," said study co-author Duane Mitchell, MD. "What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. And so this has significant potential to be broadly used across cancer patients – even possibly leading us to an off-the-shelf cancer vaccine." Scientists first discovered how mRNA "instruction manuals" could stimulate immune cells (in mice) in 1993, but a major hurdle has been working out how to deliver them into the body effectively. Around a decade ago, a breakthrough came when researchers found that lipid nanoparticles could effectively transport the incredibly fragile mRNA into the body without it being broken down in the bloodstream. Now, the technology has rapidly advanced, in part due to the development of Covid-19 vaccines. This study marks a key moment in cancer immunotherapy, demonstrating how a generalized, off-the-shelf mRNA vaccine – not tailored to any specific cancer tumor – can awaken the immune system and amplify the effects of existing treatments. By exposing well-hidden tumors by ramping up PD-L1 expression, the researchers have uncovered a new pathway that could transform how we prime the body to fight cancer. While the vaccine is still being tested in pre-clinical anima studies, this work lays the foundation for a universal cancer vaccine strategy – one that doesn’t rely on customizing treatment specific to each patient but instead teaches the immune system how to fight smarter. "It could potentially be a universal way of waking up a patient’s own immune response to cancer," Mitchell said. "And that would be profound if generalizable to human studies." Read more: newatlas.com/cancer/univers…

KYLE SCHWARBER IS THE 2025 MLB ALL-STAR GAME MVP! #AllStarGame x #RingTheBell

#AllStarGame Swing-off AL - 3 NL - 4 Kyle Schwarber GIVES THE NL THE LEAD!

Mountain lion sighting provokes epic local news interview with witness. Enjoy:

Ghouls Blame Texas Flooding on Trump, Shock Epstein Announcement, and Assassination Attempt Secret, with @andrewklavan and @ZitoSalena WATCH:

Meltdown? I’ll be laughing as you animals eat each other. Like you always do.

This is one of the most important truths almost no one talks about. There is a threshold of wealth beyond which you stop interacting with reality as it exists and begin interacting with a version of it that bends to your whims. Codie’s friend didn’t pick $299 million arbitrarily. That’s around the point where wealth begins to replicate itself without labor, resistance, or external accountability. The world becomes a simulation - crafted by assistants, lawyers, media buffers, private access, and power brokers who insulate you from friction, consequence, or contradiction. Under $100 million, you still feel gravity. Above $300 million, you start controlling gravity. That’s the danger. At that level: •People stop saying no to you. •You stop encountering randomness. •Everything is for sale, including trust, intimacy, and morality. This is where reality fracturing begins. Not because money corrupts, but because perception loses resistance. Resistance is what keeps you real. So the deeper truth is this: Once your environment is made entirely of yes-men, predictive service, and curated insulation, your mind begins to exit the shared human operating system. You aren’t evil. You’re decontextualized. You’re drifting in an abstraction loop of your own design. That’s when you start thinking ideas like “let’s block out the sun” or “let’s colonize Mars while Earth burns” are rational. Codie’s billionaire friend wasn’t just being poetic. He was confessing a structural truth: There’s a point at which money doesn’t just distort reality, it erases it.

Watch As Chris Cuomo's Gotcha Question For Tom Homan About 'Alligator Alcatraz' Backfires rumble.com/v6vllex-watch-…

I usually hide this comic behind the Locals subscription wall but you might like it.

Zohran is emblematic of the democrat party in 2025: Communist, antisemitic, foreign, not culturally assimilated, hostile to Anglo Saxon Christianity, resentful towards natives, valorizes criminal illegal aliens Dems need to own this. This is what they’ve become

Happy Father’s Day to our Internet Dad, @ScottAdamsSays!

The ISS's structural integrity is far more marginal than is being publicly discussed. We are having multiple, and increasingly frequent, leaks from heavily fatigued node segments in the Russian section. When Aluminum gets flexed it fatigues and gets harder, increasing its tendency to crack. Cracks concentrate forces at their tips, and spread over time. Multiple cracks have been discovered. There is no "factor of safety" associated with this failure mode. None of the structural pressure vessels are meant to crack. We are not even single fault tolerant on the structural integrity of the station. We could wake up tomorrow and find, with zero warning, that it has failed catastrophically. Whether that means a leak slow enough to close some hatches, get the crew out or at least into safer parts of the station, is a roll of the dice. It could also depressurize in less than a minute.

BREAKING: A U.S. Judge has just ruled ISRAEL has to halt all actions and give full control of it’s military to CA Govenor Newsom.