Cory Simpson, MD, PhD, FAAD (he/him)

New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/view/…

Excited to be representing @SimpsonLabUW in sunny 😎 San Diego 🌴 for #ASCB2024 #CellBio2024 @ASCBiology

Starting the migration to the other place, using handle @SimpsonLabUW …hoping to find the old #sciencetwitter and #dermtwitter crowds.

Proud of med student Rafael Homer whose summer research project @SimpsonLabUW @DermatologyUW won 2nd place in the @uwsomwwami Wyoming site poster competition! Rafael also won a travel award to attend the Western Medical Research Conference & was chosen for an oral presentation🤩

@drhankopelman Agree "Research Fever" is out of control in Derm (jamanetwork.com/journals/jamad…). Your reference cites NRMP so I think they include abstracts+presentations. I advise applicants not to get discouraged by the stats. Many inflate their number w/rotation talks & case reports "in progress."

@CorySimpsonMD mean number of research items per allopathic applicant matched into dermatology residency has tripled from 5.7 in 2007 to 19.0 in 2020. For re-applicants it’s 25. These numbers are increasing there is no denying that. jaad.org/article/S0190-… jaad.org/article/S0190-…

Ever wondered what it takes to become a dermatologist? 🩺 My journey from medical school to residency has been an incredible one, filled with challenges and triumphs. I have 9 tips to help you on your path to becoming a dermatologist!

@drhankopelman Great advice overall but “25+ papers” should be clarified unless you have other data. The NRMP stats I saw lump together abstracts, presentations & pubs. Abstracts/presentations are way faster and inflate the total. I worry about perpetuating imposter syndrome with the 25+ stat.

Thinking about #dermatology? Here are my takeaways: 1️⃣ Rotate at programs—this is critical. 2️⃣ Build strong relationships with residents and directors. 3️⃣ Prioritize research—average applicants have 25+ papers. 4️⃣ Be prepared for setbacks and extra steps (pre-fellowships help!). 5️⃣ Never give up on your dream.

Exciting week @SimpsonLabUW @DermatologyUW celebrating🍾our newest paper @JCI_insight (see separate🧵). which uncovered a mechanism that drives the pathology #Grover disease and was reversed using MEK inhibitors. Special thanks to Arti for making an amazing Indian lunch buffet!

@CterminiPhD @TheVFoundation @fredhutch Great news! Congratulations🍾

Beyond excited to share that I was awarded V Scholar Grant! With this funding, our lab will study how heparan sulfate glycans influence acute myeloid leukemia development and therapy resistance. Thanks for the support of our work @TheVFoundation @fredhutch ♥️ 🐁 🩸 🔮

Hope this will finally move the needle for severe drug reactions like SJS & TEN, nightmare consults in #dermatology. No Rx has great evidence to halt skin/mucosal sloughing that can be fatal. JAKi remains to be rigorously tested in patients/RCT but could change standard of care.

Nature research paper: Spatial proteomics identifies JAKi as treatment for a lethal skin disease go.nature.com/3A1ld7K

This program has been an outstanding opportunity for networking with peers, receiving grant feedback, learning how to navigate the new PI path, and getting sage career advice from leading physician-scientists. 10/10 highly recommend @the_asci. Consider applying

Proud of all co-authors & grateful to our collaborators @umichmedicine & @PennSbdrc including @drdremchu. Thanks to @NIH_NIAMS & @FIRST_Skin for lab support and @LEOFondet for funding my effort to find shared mechanisms & treatment strategies for rare skin #blistering diseases.

Finally, we reasoned the same mechanism could drive spontaneous Grover disease (ie, not drug-induced). Accordingly, we found ERK hyper-activation in Grover disease lesions and propose MEK inhibitors may be therapeutic for this idiopathic disorder lacking any FDA-approved therapy.

New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/view/…

Early-Faculty Physician-Scientists! Nominations are open for the ASCI Young Physician-Scientist Awards. Award Benefits include access to @JointMeeting, networking and career development opportunities. Deadline: Oct. 23 More info: buff.ly/3XUL9ex

Great lunch @SimpsonLabUW⁩ ⁦@DermatologyUW⁩ for lots of celebrating including Arti’s birthday 🥳 More good news to share soon now that I’m out from under the cloud of this R01 submission 😮‍💨📝 ✅🤞