David Lee, MD

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David Lee, MD

David Lee, MD

@DaveLeeERMD

Clinician-scientist, emergency physician, studies risk factors of chronic disease, advocate of health not more health care, opinions all my own.

New York, NY Katılım Ocak 2019
70 Takip Edilen8.7K Takipçiler
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David Lee, MD
David Lee, MD@DaveLeeERMD·
Our study explaining the pathophysiology of acute COVID has been published by ERJ, the flagship scientific journal of the European Respiratory Society @ERSpublications. Here, we describe how severe COVID-19 is NOT a viral pneumonia, but a post-viral autoimmune attack of the lung.
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David Lee, MD
David Lee, MD@DaveLeeERMD·
Along with a lay article written very nicely by the first author of the work, Matthew Woodruff. Impressive to see a scientist be able to distill their own work for all audiences. iflscience.com/long-covid-how…
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Resia Pretorius
Resia Pretorius@resiapretorius·
Great paper in Brain reviewed in medpagetoday: “Platelet aggregates and microthrombi were found adhering to endothelial cells along vascular lumina, and deposits of immune complexes were found on endothelial cells and platelets” medpagetoday.com/neurology/long…
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David Lee, MD
David Lee, MD@DaveLeeERMD·
PANDAS and antibodies against cholinergic interneurons. We physicians should stop calling things psychosomatic and admit our own ignorance.
Danilo.Buonsenso_Surf4Children@surf4children

one of the best talk ever was today on PANDAS! I am less surprised that #LongCovidKids are neglected, seeing how PANDAS is despite decades of knowledge and established link with Strep! The medical community need to do much more for post inf conditions. Thanks @iicoxford for this

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David Lee, MD
David Lee, MD@DaveLeeERMD·
@themirandag Generally in HLH, affected individuals develop fevers, a rash, an abnormally large liver (hepatomegaly), and an abnormally large spleen (splenomegaly). That doesn't sound like the same disease as 1918 or 2019, which presented with very specific symptoms. rarediseases.org/rare-diseases/…
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carrot🥕🥕
carrot🥕🥕@themirandag·
@DaveLeeERMD There is no distinct pattern to distinguish its onset. Could be genetic predisposition fHLH, in people w/ autoimmune/ rheumatic conditions its called (MAS) Macrophage activation syndrome. Viral/vaccine or iatrogenic induced secondary HLH.
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David Lee, MD
David Lee, MD@DaveLeeERMD·
Reading The Great Influenza by John M. Barry. On page 187: "For this was no ordinary pneumonia. Dr. Roy Grist, one of the army physicians at the hospital, wrote a colleague, 'These men start with what appears to be an ordinary attack of LaGrippe or Influenza,'
David Lee, MD@DaveLeeERMD

Reading Edwin O. Jordan's 1927 survey of pandemic influenza of 1918-1919. It's important to remember that something differentiated that strain of influenza from the others that preceded or followed it. Sobering to see them also describe a URI prodrome to the clinical entity.

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David Lee, MD
David Lee, MD@DaveLeeERMD·
Can anyone think of an autoimmune disease that causes pulmonary hemorrhage and also affects the blood vessels in the nose? Maybe that's the rheumatologic condition that caused deaths in 1918.
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David Lee, MD
David Lee, MD@DaveLeeERMD·
So then the coronavirus 2019 may very well be a virus triggered autoimmune attack of the lungs inducing microvascular thrombosis of the lung, in addition to ischemic damage to other organs (e.g., the brain and small fiber neurons).
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David Lee, MD
David Lee, MD@DaveLeeERMD·
Interesting to read this and wonder if history is repeating itself or if many pandemics occur because every so often one of our typical run-of-the-mill viruses (influenza, coronavirus, etc.) develops an epitope that is cross-reactive with important self-antigens.
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David Lee, MD
David Lee, MD@DaveLeeERMD·
Reading Edwin O. Jordan's 1927 survey of pandemic influenza of 1918-1919. It's important to remember that something differentiated that strain of influenza from the others that preceded or followed it. Sobering to see them also describe a URI prodrome to the clinical entity.
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