Del Valle Lab

Excited to be co-chairing the 2026 Peptides GRC along with Flo Brunel of NovoNordisk! We're looking forward to hearing from an amazing slate of speakers across #PeptideScience. Not to be missed...apply today! grc.org/chemistry-and-…

Ever wondered how intra-strand staples impact beta-sheet stability? Check out our @J_A_C_S paper on an easy method to promote peptide folding and amyloid seeding activity. Congrats to Abha and Isaac!! pubs.acs.org/doi/10.1021/ja…

Some recent publication news from the lab... First, congrats to @mmwright417 for her paper exploring the impact of azapeptoid residues on collagen stability, now out in Peptide Science! onlinelibrary.wiley.com/doi/10.1002/pe…

Hot off the press in @NatureChemistry: Our paper on seed-competent stapled peptides that mimic the core fold of pathological tau! rdcu.be/ej4ik Huge congrats to Isaac, Ben, and collaborators in the Jiang and Vidal labs. #PeptideScience #tau nature.com/articles/s4155…

Check out this Just Accepted paper from @Avraz__Anwar describing a streamlined synthesis of N-amino peptides. This general protocol will vastly accelerate studies on amide-to-hydrazide replacement in peptides. Congrats, Avraz! doi.org/10.1021/acs.jo…

RSC Chemical Biology paper in collaboration with the Stahelin just accepted! Stapled peptides targeting the dimer interface of the Ebola virus VP40 matrix protein. Congrats to Madi, Roopashi, and collaborators in the Stahelin and Chapagain labs! doi.org/10.1039/D5CB00…

The fun with unnatural proline surroagtes continues... Check out our paper on stabilized aPP proteomimetics. Congrats to first author @mmwright417 and special thanks to collaborators in the Horne and Smith labs! nature.com/articles/s4200…

Our paper on delta-heteroatom proline surrogates in collagen is now online. Congrats to Taylor, Madi, and Natalia! pubs.rsc.org/en/content/art…

Congrats to @Avraz__Anwar, whose total synthesis of marformycins A&D appeared in in @JOC_OL! Special thanks to Yassin and collaborators in the @R_H_Ebright lab. doi.org/10.1021/acs.or…

Last week the lab got together to bid farewell to @b_raj12 aka Dr. "beta-bracelet". Congrats, Ben, and all the best in Chicago!

New Acc. Chem. Res. from the lab dropped online yesterday: pubs.acs.org/doi/10.1021/ac…. Right on first author Isaac's birthday, and one day before second author Madi's birthday. Practically twinsies! Happy bday guys! 🎂

Huge week for 5th year ⁦⁦@b_raj12⁩. Thesis defense, Dow outstanding grad student award, and birthday to boot! Congrats Ben! 🥂

At last... we're thrilled to send our story on macrocyclic mini-tau seeds out into the world. Organic chem, protein mimicry, cryo-EM, cell function; something for everyone! Congrats to Isaac & Xueyong, and collabs from Purdue and IUSM! chemrxiv.org/engage/chemrxi…

Congrats to Isaac Angera for taking home a 2nd place poster award at the 2024 Peptides GRC!! Well-deserved! Stay tuned for more on his exciting foray into "mini-tau" macrocycles.

#OnTheCover Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide-Modified Analogues (ChemMedChem 1/2024) (J. R. Del Valle et al.) @DelValleLab onlinelibrary.wiley.com/doi/10.1002/cm…

4 new group members this month! Thrilled to welcome postdoc Abha Dangi, and 1st year grad students Ana-Teresa Mendoza, Alexandre Renon, and Fadwa Kamari. Welcome to the team!

Had an amazing time at the Purdue University Notre Dame Symposium (PUNDS). There were so many great talks/research being done from each university. With that being said, I am honored to receive the Best Presentation Award for my talk!

Hats off to Theo and Natalia, who passed their candidacy exams this month!👏🎉 Cake, coats, and congrats on job well done!!

Almost the end of #AusPeptide2023 sadly! Thank you all for coming and having a great time, giving amazing presentations and presenting fantastic posters. Hope to see everyone again soon! 🇦🇺👀🧪

Excited to share our story on cross-beta epitope mimics targeting tau propagation, out now in @J_A_C_S. Grateful to all involved on this project, and a special congrats to first author @b_raj12!! pubs.acs.org/doi/10.1021/ja…