Derek Chan

126 posts

Derek Chan banner
Derek Chan

Derek Chan

@DerekCKChan1

PhD McMaster University - siderophores, antibiotics, Trojan horse, TonB-dependent transporters

Hamilton, ON Katılım Haziran 2019
172 Takip Edilen110 Takipçiler
Derek Chan retweetledi
Lori L. Burrows
Lori L. Burrows@Dr_Lori_Burrows·
Congratulations Dr. ⁦@DerekCKChan1⁩ on a stellar defence on your #TBDT work. Thanks to external ⁦@CMKhursigara⁩ for zooming on his vacation and ⁦@gerryiidr⁩ and Marie Elliot for wide ranging questions. We'll miss you Iron Man!! Best of luck with your new gig 😊
Lori L. Burrows tweet media
English
5
3
62
2.7K
Derek Chan retweetledi
Lori L. Burrows
Lori L. Burrows@Dr_Lori_Burrows·
Big congratulations to PhD candidate ⁦⁦@veronicantran⁩ for winning a Beveridge poster award ⁦@CSM2023_Halifax⁩ for her work on mechanisms of resistance to T4P-specific #phages 🏆🎉!
Lori L. Burrows tweet media
English
1
8
63
5.2K
Derek Chan retweetledi
Lori L. Burrows
Lori L. Burrows@Dr_Lori_Burrows·
This study will use the SURFAR platform developed by @DerekCKChan1 to identify the TonB-dependent transporters used by this new conjugate molecule - developed by @brent_s_weber - to enter and kill #Pseudomonas
McMaster IIDR@McMasterIIDR

Investigating a novel “Trojan Horse” antibiotic, Eric Brown & Lori Burrows will characterize MLEB-22043’s mode of action and determine how bacteria may develop resistance. This funding supports the development of MLEB-22043 and informs the design of future antibacterial drugs.

English
0
2
14
1.9K
Derek Chan retweetledi
Zach Reitz
Zach Reitz@ZachReitzPhD·
Come for the crystal structures, stay for the implications for Trojan horse antibiotics. A beautiful and thorough study!
Zach Reitz tweet media
Lori L. Burrows@Dr_Lori_Burrows

🔥🔥 The latest from @DerekCKChan1 and @KJosts from the Tidow lab, with help from Kalinka Koteva and @gerryiidr - Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction 1/10 pnas.org/doi/10.1073/pn…

English
0
5
20
3.5K
Derek Chan retweetledi
Lori L. Burrows
Lori L. Burrows@Dr_Lori_Burrows·
🔥🔥 The latest from @DerekCKChan1 and @KJosts from the Tidow lab, with help from Kalinka Koteva and @gerryiidr - Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction 1/10 pnas.org/doi/10.1073/pn…
English
3
11
46
11.1K
Derek Chan
Derek Chan@DerekCKChan1·
@ZachReitzPhD @Dr_Lori_Burrows I wouldn’t trust results from docking alone. There are also other docking programs that may give a different prediction so experimental validation is still important 🙂
English
0
0
0
0
Zach Reitz
Zach Reitz@ZachReitzPhD·
@DerekCKChan1 @Dr_Lori_Burrows Thanks for answers! The docking seemed to be well supported by your experimental validation. I just wonder if we can trust docking in the absence of experiments, and I'm thinking the answer is still no? But I haven't worked with any of the docking software myself.
English
1
0
1
0
Derek Chan
Derek Chan@DerekCKChan1·
@ZachReitzPhD @Dr_Lori_Burrows The orientation of the molecules may not be correct but it gives us a rough idea of where they might bind in the transporter, which we can then test.
English
0
0
1
0
Zach Reitz
Zach Reitz@ZachReitzPhD·
@Dr_Lori_Burrows @DerekCKChan1 Also, I wonder how safe this assumption is, more broadly: "Docking assumed that the siderophore-Fe3+ complexes are in similar orientations in their native transporter and in FpvB."
English
2
0
0
0

Keşfet

@CMKhursigara @veronicantran @CSM2023_Halifax @McMasterIIDR @BBS_McMasterU @brent_s_weber @Dr_Lori_Burrows @PNASNews