Dhruba

DBT Success Stories 2025 | In Spotlight Targeting novel molecular pathways to combat Huntington’s disease 🧠 Researchers have advanced new insights into Huntington’s disease, a progressive neurodegenerative disorder caused by the expansion of polyglutamine repeats in the huntingtin protein. The disease leads to impaired motor function, cognitive decline, and neuronal loss — and currently has no cure. Researchers identified a novel molecular pathway that may help suppress Huntington’s disease phenotypes. Using Drosophila models and mouse neuroblastoma cell lines, they found that PTEN downregulation significantly reduced protein aggregation and apoptosis, leading to notable rescue effects in affected cells. These findings position PTEN downregulation as a promising potential therapeutic target, opening new avenues for future medical interventions against Huntington’s disease. 🧬 Research insights shared by Dr. M. Dhruba Singh, Scientist IV, Cellular and Molecular Neuroscience Department, BRIC-National Brain Research Centre, Gurgaon 🔬 Study conducted using Drosophila and mammalian cell models #DBTSuccessStories #Neurodegeneration #HuntingtonsDisease @DrJitendraSingh @rajesh_gokhale @BricDbt @NABI_India @bric_ils @NIPGRsocial @NImmunology @FollowDbtNibmg @HydNiab @BRIC_CDFD @DBT_NCCS_Pune @ICGEB @DBT_inStem @RGCB_Trivandrum @THSTIFaridabad @ICGEBNewDelhi @unescorcb @BIRAC_2012

Excited to share our new publication at molecular neurobiology with our collaborator Dr. Bhavani @urssahu @DBT_NBRC link.springer.com/article/10.100…

Announcing the Regional Young Investigators’ Meeting (RYIM) Delhi-NCR from 19-21 March 2025 at National Brain Research Centre, Manesar, & Ashoka University, Sonipat. 📅 19-21 March 2025 📷 CYC on 20 March 2025 📷buff.ly/3DVjfas Register by: 15 February 2025 ps retweet

@NCBS_Bangalore @IISERPune @AshokaUniv @DAEIndia @TIFRScience Congratulations sir

n/n We are excited to welcome Prof. LS Shashidhara as our new director! An accomplished developmental biologist with tremendous experience in institutional building, Shashi cares about science, outreach and policy in India & internationally. We look forward to working with him!

1/n The winds of change are blowing @NCBS_Bangalore! Satyajit (Jitu) Mayor, passes the baton to our new director, LS Shashidhara. The NCBS community expresses its heartfelt gratitude to Prof. Mayor for his able stewardship of the institution as Dean 2008-13 & as director 2013-23.

Gene Editing to Alter Whole Species Gets Limited Backing, via @nytimes nytimes.com/2016/06/09/sci…