Differentiation Journal

Differentiation is the flagship journal of the International Society of Differentiation (ISD) @intlsocdiff. We are a multidisciplinary journal focusing on principal subject areas of cell and tissue differentiation, embryonic development, cellular structure and function, and 1/4

Tannaz Sakhavarz et al. provide the first comprehensive evidence that Palmatine functions as a potent, multi-level osteo-inductive molecule in human adipose-derived mesenchymal stem cells. Learn more: sciencedirect.com/science/articl…

Sydney Popsuj et al. designed and tested novel sgRNA expression plasmids targeting 8 different neurodevelopmental genes in the model tunicate Ciona robusta. Learn more: sciencedirect.com/science/articl…

Findings from Basant Kumar et al. identify a promoter-level reciprocal repression circuit between Goosecoid and Ventx1.1 and suggest that this circuitry contributes to the refinement of dorsoventral patterning in Xenopus gastrulae: sciencedirect.com/science/articl…

Luis Herrera et al. provide the first structural framework for understanding prenatal human heel fat pad organization, extending beyond classical models of adipose tissue development. Learn more: sciencedirect.com/science/articl… #devbio #differentiation

“Bridging cells: Potential crosstalk between the peripheral and central olfactory sensory system,” by Jorge Torres-Paz, Ricardo Ceriani, and Kathleen E. Whitlock. Read the Article from the special issue "Splicing in Development and Disease": doi.org/10.1016/j.diff…

Seung Hoon Lee et al. establish developmental endothelial locus-1 as a key osteoclast-derived coupling factor that drives new bone formation in ankylosing spondylitis. Learn more: doi.org/10.1016/j.diff…

Findings from Rogério Salinas Ferreira et al. provide insights into resveratrol-induced osteogenesis and support its potential as a bioactive modulator of osteogenic pathways in periodontal ligament mesenchymal cells for bone regenerative therapies: doi.org/10.1016/j.diff…

Submit your ENS papers for our special issue. We are excited to consolidate this timely and important research area topic for the community.

NEW 🚨 Submit to the “Enteric Nervous System Development and Repair” focus issue by October 31, 2026! Guest editors: Julia Ganz and @uribelabrice. Learn more: sciencedirect.com/special-issue/… #devbio #differentiation

It’s not too late! Submit your research on splicing in development and disease to the Differentiation special issue led by Guest Editors Natoya Peart and Karine Choquet by June 30, 2026: sciencedirect.com/special-issue/…

Article from "Splicing in Development and Disease": Evan C. Brooks, Charles W. Griffin, and Katherine A. Fantauzzo review the roles of RNA-bidning protein SRSF3 in development and cellular differentiation. Learn more: doi.org/10.1016/j.diff… @ecbrooks96 @Fantauzzo_Lab

“NNMT as a therapeutic target in fibrosis: Insights from the heart, liver, kidneys, and lungs,” by Shi-Yan Lai et al. Learn more: doi.org/10.1016/j.diff…

Preethi Dharmendhran et al. review current protocols for differentiating human pluripotent stem cells and human adipose-derived stem cells into brown adipocytes, assessing methodological consistency, differentiation outcomes, and key limitations: doi.org/10.1016/j.diff…

Results from Dharitree Samal, Vaijayanti Kale, and Prasad Pethe clearly demonstrate that BAP1 is required for human neuronal progenitor cell formation, since it regulates neuronal and EMT genes. Read the research article to learn more: doi.org/10.1016/j.diff…

Findings from D. C. Andia et al. demonstrate that low and high osteogenic potential of periodontal ligament-derived mesenchymal stem cells correlates with RUNX2, SP7, EZH2 and KDM6B expression. Read the open access article to learn more: doi.org/10.1016/j.diff…

Federica Quacquarelli et al. highlight the relevance of ex vivo human cellular models to examine paracrine interactions between osteoblasts and adipocytes and confirmed the role played by adipocyte-secreted factors in osteoblast transdifferentiation: doi.org/10.1016/j.diff…

“Comprehensive defect detection in mouse embryos and the heart by combining automated phenotyping with novel population averages and atlases,” by Ella M. M. A. Martin et al. Read the open access article to learn more: doi.org/10.1016/j.diff…

Cagney E. Coomer et al. found Her9 is required for the migration, differentiation, and survival of neural crest cells. Learn more: doi.org/10.1016/j.diff… @ukybiology

Explore the special collection of papers on osteo biology—highlighting research and reviews from differentiation to regeneration—curated by Editors-in-Chief Loydie Jerome-Majewska, @RogersLabUCD, and @uribelabrice: sciencedirect.com/special-issue/…

Jessica Cristina Marín-Llera et al. explored the role of CEK8 (Ephrin-A4) in early tendon differentiation in the chicken limb and its interaction with WNT/β-catenin and TGF-β pathways during tendon blastema formation. Learn more: doi.org/10.1016/j.diff…